Hepatocellular carcinoma in GNMT-/- mice

Toxicology and Applied Pharmacology

Volumn 237, Issue 2, 2009, Pages 246-

  Wagner, Conrad ^a   Luka, Zigmund ^a   Mato, José M ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN B1; GLYCINE METHYLTRANSFERASE;

CARCINOGENICITY; CHRONIC HEPATITIS; EXPERIMENTAL MODEL; FATTY LIVER; GLYCOGEN STORAGE DISEASE; KNOCKOUT MOUSE; LETTER; LIVER CELL CARCINOMA; MEDICAL RESEARCH; MOUSE; NONHUMAN; PUBLICATION;

AFLATOXIN B1; ANIMALS; CARCINOMA, HEPATOCELLULAR; FEMALE; GLYCINE N-METHYLTRANSFERASE; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, TRANSGENIC; PUBLICATIONS;

MUS;

EID: 67349200946     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.03.017     Document Type: Letter

References (5)

1. Liu S.-P., et al. Glycine N-methyltransferase -/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology 46 (2007) 1413-1425
2. Liao Y.-J. Characterization of a glycine N-methyltrans-ferase gene knockout mouse model for hepatocellular carcinoma: implications of the gender disparity in liver cancer susceptibility. Int. J. Cancer 124 (2009) 816-826
3. Luka Z. A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme. Transgenic Res. 15 (2006) 393-397
4. Marti{dotless}nez-Chantar M.L., et al. Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology 47 (2008) 1191-1199
5. Yen C.-H. Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect. Toxicol. Appl. Pharmacol. 235 3 (2009) 296-304