Optimization of metabolic pathways for bioconversion of lignocellulose to ethanol through genetic engineering

Biotechnology Advances

Volumn 27, Issue 5, 2009, Pages 593-598

  Chen, Jienan ^a,b   Zhang, Weitao ^a   Tan, Li ^a   Wang, Yiqiang ^a   He, Gang ^a  

^a CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY   (China)

^b Transpoints Inc   (United States)

Author keywords

Ethanol; Gene knockout; Lignocellulose; Metabolic engineering

Indexed keywords

A-CARBON; ACETYL COENZYME A; ALCOHOL DEHYDROGENASE; E. COLI; ETHANOL CONCENTRATIONS; ETHANOL PRODUCTION; GENE KNOCKOUT; GENES ENCODING; LIGNOCELLULOSE; METABOLIC ENGINEERING; METABOLIC PATHWAYS; MICROAEROBIC CONDITIONS; PARENT STRAIN; PYRUVATE; PYRUVATE DECARBOXYLASE; PYRUVATE FORMATE LYASE; PYRUVATE METABOLISM; ZYMOMONAS MOBILIS;

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; CELLULOSE; ENZYMES; ESCHERICHIA COLI; ETHANOL; GENETIC ENGINEERING; GLUCOSE; GROWTH KINETICS; LARGE SCALE SYSTEMS; LIGNIN; METABOLISM; ORGANIC ACIDS;

BIOETHANOL;

ACYLTRANSFERASE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE; FORMATE C ACETYLTRANSFERASE; FORMATE C-ACETYLTRANSFERASE; GLUCOSE; LIGNIN; LIGNOCELLULOSE; PYRUVATE DECARBOXYLASE;

CELLULOSE; ENZYME ACTIVITY; ETHANOL; GENETIC ENGINEERING; LIGNIN; METABOLISM; OPTIMIZATION; RECOMBINATION;

ARTICLE; ENZYMOLOGY; ESCHERICHIA COLI; FERMENTATION; GENE INACTIVATION; GENETIC ENGINEERING; GENETICS; METABOLISM; METHODOLOGY; MOLECULAR CLONING; POLYMERASE CHAIN REACTION; ZYMOMONAS;

ACETYLTRANSFERASES; ALCOHOL DEHYDROGENASE; ALDEHYDES; CLONING, MOLECULAR; ESCHERICHIA COLI; ETHANOL; FERMENTATION; GENE KNOCKOUT TECHNIQUES; GENETIC ENGINEERING; GLUCOSE; LIGNIN; POLYMERASE CHAIN REACTION; PYRUVATE DECARBOXYLASE; ZYMOMONAS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; ZYMOMONAS MOBILIS;

EID: 67349187911     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2009.04.021     Document Type: Article

References (36)

1. Baba T., Ara T., Hasegawa M., Takai Y., Okumura Y., Baba M., et al. Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol Syst Biol 2 (2006) 1-11
2. Badger P.C. Ethanol from cellulose: a general review. In: Janick J., and Whipkey A. (Eds). Trends in New Crops and New Uses (2002), ASHS Press, Alexandria, VA 17-21
3. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
4. Brown T.D.K., Jones-Mortimer M.C., and Kornberg H.L. The enzymic interconversion of acetate and acetyle-coenzyme A in Escherichia coli. J Gen Microbiol 102 (1977) 327-336
5. Clark D.P. The fermentation pathways of Escherchia coli. FEMS Microbiol Rev 63 (1989) 223-234
6. Datsenko K.A., and Wanner B.L. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci U S A 97 12 (2000) 6640-6645
7. Dien B.S., Cotta M.A., and Jeffries T.W. Bacteria engineered for fuel ethanol production: current status. Appl Microbiol Biotechnol 63 (2003) 258-266
8. Fairbanks G., Steck T.L., and Wallach D.F.H. Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. Biochemistry 10 (1971) 2606-2617
9. BAD promoter. J Bacteriol 177 (1995) 4121-4130
10. Haldimann A., and Wanner B.L. Conditional-replication, integration, excision, and retrieval plasmid-host systems for gene structure-function studies in bacteria. J Bacteriol 183 21 (2001) 6384-6393
11. Hasona A., Kim Y., Healy F.G., Ingram L.O., and Shanmugam K.T. Pyruvate formate lyase and acetate kinase are essential for anaerobic growth of Escherichia coli on xylose. J Bacteriol 186 (2004) 7593-7600
12. Ho N.W.Y., Chen Z., and Brainard A.P. Genetically engineered Saccharomyces yeast capable of effective cofermentation of glucose and xylose. Appl Environ Microbiol 64 (1998) 1852-1859
13. Ingram L.O., and Doran J.B. Conversion of cellulosic materials to ethanol. FEMS Microbiol Rev 16 (1995) 235-241
14. Ingram L.O., Conway T., Clark D.P., Sewell G.W., and Preston J.F. Genetic engineering of ethanol production in Escherichia coli. Appl Environ Microbiol 53 (1987) 2420-2425
15. Ingram L.O., Aldrich H.C., Borges A.C.C., Causey T.B., Martinez A., Morales F., et al. Enteric bacterial catalyst for fuel ethanol production. Biotechnol Prog 15 (1999) 855-866
16. Jarboe L.R., Grabar T.B., Yomano L.P., Shanmugan K.T., and Ingram L.O. Development of ethanologenic bacteria. Adv Biochem Eng Biotechnol 108 (2007) 237-261
17. Jeffries T.W., and Jin Y.S. Metabolic engineering for improved fermentation of pentoses by yeast. Appl Microbiol Biotechnol 63 (2004) 495-509
18. Kumari S., Beatty C.M., Browning D.F., Busby S.J.W., Simel E.J., Hovel-Miner G., et al. Regulation of acetyl coenzyme A synthetase in Escherichia coli. J Bacteriol 182 (2000) 4173-4179
19. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
20. Laszlo A., and Lawrence P. Parallel induction and synthesis of Pdc and Adh in anoxic maize roots. Mol Gen Genet 192 (1983) 110-117
21. Lillie R.D. H. J. Conn's Biological Stains: A Handbook on the Nature and Uses of the Dyes Employed in the Biological Laboratory. 9th ed (1977), The Williams and Wilkins Co., Baltimore, MD
22. Lynd L.R., Weimer P.J., Zyl W.H.V., and Pretorius I.S. Microbial cellulose utilization: fundamentals and biotechnology. Microbiol Mol Biol Rev 66 3 (2002) 506-577
23. Mackenzie K.F., Eddy C.K., and Ingram L.O. Modulation of alcohol dehydrogenase isozyme levels in Zymomonas mobilis by iron and zinc. J Bacteriol 171 (1989) 1063-1067
24. Moniruzzaman M., Lai X., York S.W., and Ingram L.O. Isolation and molecular characterization of high-performance cellobiose-fermenting spontaneous mutants of ethanologenic Escherichia coli KO11 containing the Klebsiella oxytoca casAB operon. Appl Environ Microbiol 63 12 (1997) 4633-4637
25. Murphy K.C. Use of bacteriophage lambda recombination functions to promote gene replacement in Escherichia coli. J Bacteriol 180 (1998) 2063-2071
26. Murphy K.C., Campellone K.G., and Poteete A.R. PCR-mediated gene replacement in Escherichia coli. Gene 246 (2000) 321-330
27. Neale A.D., Scopes R.K., Wettenhall R.E., and Hoogenraad N.J. Nucleotide sequence of the pyruvate decarboxylase gene from Zymomonas mobilis. Nucleic Acids Res 15 4 (1987) 1753-1761
28. Ohta K., Beall D.S., Mejia J.L., Shanmugam K.T., and Ingram L.O. Genetic improvement of Escherichia coli for ethanol production: chromosomal integration of Zymomonas mobilis genes encoding pyruvate decarboxylase and alcohol dehydrogenase II. Appl Environ Microbiol 57 (1991) 893-900
29. Ohta K., Beall D.S., Mejia J.L., Shanmugam K.T., and Ingram L.O. Metabolic engineering of Klebsiella oxytoca strain M5A1 for ethanol production from xylose and glucose. Appl Environ Microbiol 57 (1991) 2810-2815
30. Olofsson K., Bertilsson M., and Lidén G. A short review on SSF - an interesting process option for ethanol production from lignocellulosic feedstocks. Biotechnol Biofuels 1 (2008) 7
31. Sambrook J., and Russell D. Molecular Cloning: A Laboratory Manual. 3rd ed (2001), Cold Spring Harbor Laboratory, New York
32. Williamson V.M., Bennetzen J., Young E.T., Nasmyth K., and Hall B.D. Isolation of the structural gene for alcohol dehydrogenase by genetic complementation in yeast. Nature 283 (1980) 214-216
33. Yu D., Ellis H.M., Lee E.C., Jenkins N.A., Copeland N.G., and Court D.L. An efficient recombination system for chromosome engineering in Escherichia coli. Proc Natl Acad Sci U S A 97 (2000) 5978-5983
34. Zaldivar J., Neilsen J., and Olsson L. Fuel ethanol production from lignocellulose: a challange for metabolic engineering and process integration. Appl Microbiol Biotechnol 56 (2001) 17-34
35. Zhang M., Eddy C., Deanda K., Finkelstein M., and Picataggio S. Metabolic engineering of a pentose metabolism pathway in ethanologenic Zymomonas mobilis. Science 267 (1995) 240-243
36. Zhu J., and Shimizu K. The effect of pfl gene knockout on the metabolism for optically pure D-lactate production by Escherichia coli. Appl Microbiol Biotechnol 64 (2004) 367-375