Urinary cortisol/cortisone ratios in hypertensive and normotensive cats

Journal of Feline Medicine and Surgery

Volumn 11, Issue 6, 2009, Pages 442-448

  Walker, David J ^a   Elliott, Jonathan ^a   Syme, Harriet M ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; ANTIHYPERTENSIVE AGENT; BIOLOGICAL MARKER; CORTISONE; HYDROCORTISONE;

ANIMAL; ANIMAL DISEASE; ARTICLE; CAT; CAT DISEASE; CHRONIC KIDNEY FAILURE; COMPARATIVE STUDY; FEMALE; HYPERTENSION; KIDNEY FUNCTION TEST; MALE; NONPARAMETRIC TEST; RADIOIMMUNOASSAY; URINE;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOLOGICAL MARKERS; CAT DISEASES; CATS; CORTISONE; FEMALE; HYDROCORTISONE; HYPERTENSION; KIDNEY FAILURE, CHRONIC; KIDNEY FUNCTION TESTS; MALE; RADIOIMMUNOASSAY; STATISTICS, NONPARAMETRIC;

EID: 67349183675     PISSN: 1098612X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jfms.2008.10.004     Document Type: Article

References (29)

1. Syme H.M., Barber P.J., Markwell P.J., and Elliott J. Prevalence of systolic hypertension in cats with chronic renal failure at initial evaluation. J Am Vet Med Assoc 220 (2002) 1799-1804
2. Jensen J., Henik R.A., Brownfield M., and Armstrong J. Plasma renin activity and angiotensin I and aldosterone concentrations in cats with hypertension associated with chronic renal disease. Am J Vet Res 58 (1997) 535-540
3. Rose S.A., Kyles A.E., Labelle P., et al. Adrenalectomy and caval thrombectomy in a cat with primary hyperaldosteronism. J Am Anim Hosp Assoc 43 (2007) 209-214
4. Ash R.A., Harvey A.M., and Tasker S. Primary hyperaldosteronism in the cat: a series of 13 cases. J Feline Med Surg 7 (2005) 173-182
5. DeClue A.E., Breshears L.A., Pardo I.D., Kerl M.E., Perlis J., and Cohn L.A. Hyperaldosteronism and hyperprogesteronism in a cat with an adrenal cortical carcinoma. J Vet Intern Med 19 (2005) 355-358
6. Rijnberk A., Voorhout G., Kooistra H.S., et al. Hyperaldosteronism in a cat with metastasised adrenocortical tumour. Vet Q 23 (2001) 38-43
7. Moore L.E., Biller D.S., and Smith T.A. Use of abdominal ultrasonography in the diagnosis of primary hyperaldosteronism in a cat. J Am Vet Med Assoc 217 (2000) 213-215
8. Flood S.M., Randolph J.F., Gelzer A.R., and Refsal K. Primary hyperaldosteronism in two cats. J Am Anim Hosp Assoc 35 (1999) 411-416
9. MacKay A.D., Holt P.E., and Sparkes A.H. Successful surgical treatment of a cat with primary aldosteronism. J Feline Med Surg 1 (1999) 117-122
10. Conn J.W., and Louis L.H. Primary aldosteronism: a new clinical entity. Trans Assoc Am Physicians 68 (1955) 215-231
11. Javadi S., Djajadiningrat-Laanen S.C., Kooistra H.S., et al. Primary hyperaldosteronism, a mediator of progressive renal disease in cats. Domest Anim Endocrinol 28 (2005) 85-104
12. Syme H.M., Markwell P.J., and Elliott J. Aldosterone and plasma renin activity in cats with hypertension and/or chronic renal failure. [abstract]. J Vet Intern Med 16 (2002) 354
13. White P.C. 11beta-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess. Am J Med Sci 322 (2001) 308-315
14. Stewart P.M., Krozowski Z.S., Gupta A., et al. Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11 beta-hydroxysteroid dehydrogenase type 2 gene. Lancet 347 (1996) 88-91
15. Homma M., Tanaka A., Hino K., et al. Assessing systemic 11beta-hydroxysteroid dehydrogenase with serum cortisone/cortisol ratios in healthy subjects and patients with diabetes mellitus and chronic renal failure. Metabolism 50 (2001) 801-804
16. Quinkler M., Zehnder D., Lepenies J., et al. Expression of renal 11beta-hydroxysteroid dehydrogenase type 2 is decreased in patients with impaired renal function. Eur J Endocrinol 153 (2005) 291-299
17. Quinkler M., and Stewart P.M. Hypertension and the Cortisol-Cortisone shuttle. J Clin Endocrinol Metab 88 (2003) 2384-2392
18. Schipper L., Spee B., Rothuizen J., Woutersen-van Nijnanten F., and Fink-Gremmels J. Characterisation of 11 beta-hydroxysteroid dehydrogenases in feline kidney and liver. Biochim Biophys Acta 1688 (2004) 68-77
19. Moore A., Aitken R., Burke C., et al. Cortisol assays: guidelines for the provision of a clinical biochemistry service. Ann Clin Biochem 22 (1985) 435-454
20. Wood PJ, Donovan D, Glenn C. New serum and urine radioimmunoassays for cortisone [abstract]. In: Proceedings of the XVI International Congress of Clinical Chemistry, London, 1996: 478.
21. Palermo M., Delitala G., Mantero F., Stewart P.M., and Shackleton C.H. Congenital deficiency of 11beta-hydroxysteroid dehydrogenase (apparent mineralocorticoid excess syndrome): diagnostic value of urinary free cortisol and cortisone. J Endocrinol Invest 24 (2001) 17-23
22. Tran J.Q., Kovacs S.J., McIntosh T.S., Davis H.M., and Martin D.E. Morning spot and 24-hour urinary 6 beta-hydroxycortisol to cortisol ratios: intraindividual variability and correlation under basal conditions and conditions of CYP 3A4 induction. J Clin Pharmacol 39 (1999) 487-494
23. Cauvin A.L., Witt A.L., Groves E., Neiger R., Martinez T., and Church D.B. The urinary corticoid:creatinine ratio (UCCR) in healthy cats undergoing hospitalisation. J Feline Med Surg 5 (2003) 329-333
24. Brown S., Atkins C., Bagley R., et al. Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med 21 (2007) 542-558
25. Walker B.R., Stewart P.M., Shackleton C.H., Padfield P.L., and Edwards C.R. Deficient inactivation of cortisol by 11 beta-hydroxysteroid dehydrogenase in essential hypertension. Clin Endocrinol (Oxf) 39 (1993) 221-227
26. Bailey M.A., Paterson J.M., Hadoke P.W., et al. A switch in the mechanism of hypertension in the syndrome of apparent mineralocorticoid excess. J Am Soc Nephrol 19 (2008) 47-58
27. Kawai S., Ichikawa Y., and Homma M. Differences in metabolic properties among cortisol, prednisolone and dexamethasone in liver and renal disease: accelerated metabolism of dexamethasone in renal failure. J Clin Endocrinol 60 (1985) 848-854
28. Schatz S., and Palme R. Measurement of faecal cortisol metabolites in cats and dogs: a non-invasive method for evaluating adrenocortical function. Vet Res Commun 25 (2001) 271-287
29. Syme H.M., Fletcher M.G., Bailey S.R., and Elliott J. Measurement of aldosterone in feline, canine and human urine. J Small Anim Pract 48 (2007) 202-208