Continued development of an empirical function for predicting and rationalizing protein-protein binding affinities

Biophysical Chemistry

Volumn 143, Issue 3, 2009, Pages 139-144

  Audie, Joseph ^a,b  

^a SACRED HEART UNIVERSITY   (United States)

^b CMD Bioscience   (United States)

Author keywords

Alanine scanning mutagenesis; Binding affinity; Biologics; Computational; Free energy; Hot spot; Peptide therapeutics; Protein protein recognition

Indexed keywords

ALANINE; AROMATIC COMPOUND; MUTANT PROTEIN;

ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ELECTRICITY; ENERGY TRANSFER; MOLECULAR PHYSICS; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; VALIDITY;

ALANINE; ALGORITHMS; DATABASES, PROTEIN; MULTIPROTEIN COMPLEXES; MUTANT PROTEINS; MUTATION; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; THERMODYNAMICS;

EID: 67349178167     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpc.2009.05.003     Document Type: Article

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