Oxidative stress and HIF-1α modulate hypoxic ventilatory responses after hypoxic training on athletes

Respiratory Physiology and Neurobiology

Volumn 167, Issue 2, 2009, Pages 217-220

  Pialoux, Vincent ^a,b   Brugniaux, Julien V ^b,c   Fellmann, Nicole ^a   Richalet, Jean Paul ^c   Robach, Paul ^c,d   Schmitt, Laurent ^e   Coudert, Jean ^a   Mounier, Rémi ^a,f  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITÉ PARIS 13   (France)

^d Ecole Nationale de Ski et d'Alpinisme   (France)

^e Centre National de Ski Nordique   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Athletes; HIF 1 mRNA; Intermittent hypoxia; Oxidative stress; Ventilation

Indexed keywords

ADVANCED OXIDATION PROTEIN PRODUCT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MALONALDEHYDE; MESSENGER RNA;

ACCLIMATIZATION; ACUTE HYPOXIC VENTILATORY RESPONSE; ARTICLE; ATHLETE; BREATHING; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYPOXIA; LEUKOCYTE; MALE; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RUNNING; TRAINING;

ACCLIMATIZATION; ANOXIA; EXERCISE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LEUKOCYTES; MALONDIALDEHYDE; OXIDATIVE STRESS; PHYSICAL FITNESS; PULMONARY VENTILATION;

EID: 67349173211     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2009.04.012     Document Type: Article

References (11)

1. Brugniaux J.V., Schmitt L., Robach P., Jeanvoine H., Zimmermann H., Nicolet G., Duvallet A., Fouillot J.P., and Richalet J.P. Living high-training low: tolerance and acclimatization in elite endurance athletes. Eur. J. Appl. Physiol. 96 (2006) 66-77
2. Brugniaux J.V., Schmitt L., Robach P., Nicolet G., Fouillot J.P., Moutereau S., Lasne F., Pialoux V., Saas P., Chorvot M.C., Cornolo J., Olsen N.V., and Richalet J.P. Eighteen days of "living high, training low" stimulate erythropoiesis and enhance aerobic performance in elite middle-distance runners. J. Appl. Physiol. 100 (2006) 203-211
3. Kietzmann T., and Gorlach A. Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression. Semin. Cell Dev. Biol. 16 (2005) 474-486
4. Macfarlane P.M., Wilkerson J.E., Lovett-Barr M.R., and Mitchell G.S. Reactive oxygen species and respiratory plasticity following intermittent hypoxia. Respir. Physiol. Neurobiol. (2008)
5. Mounier R., Pialoux V., Cayre A., Schmitt L., Richalet J.P., Robach P., Lasne F., Roels B., Millet G., Coudert J., Clottes E., and Fellmann N. Leukocyte's HIF-1 expression and training-induced erythropoietic response in swimmers. Med. Sci. Sports Exerc. 38 (2006) 1410-1417
6. Peng Y.J., Yuan G., Ramakrishnan D., Sharma S.D., Bosch-Marce M., Kumar G.K., Semenza G.L., and Prabhakar N.R. Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J. Physiol. 577 (2006) 705-716
7. Pialoux V., Mounier R., Brown A.D., Steinback C.D., Rawling J.M., and Poulin M.J. Relationship between oxidative stress and HIF-1 alpha mRNA during sustained hypoxia in humans. Free Radic. Biol. Med. 46 (2009) 321-326
8. Pialoux V., Mounier R., Ponsot E., Rock E., Mazur A., Dufour S., Richard R., Richalet J.P., Coudert J., and Fellmann N. Effects of exercise and training in hypoxia on antioxidant/pro-oxidant balance. Eur. J. Clin. Nutr. 60 (2006) 1345-1354
9. Pialoux V., Mounier R., Rock E., Mazur A., Schmitt L., Richalet J.P., Robach P., Brugniaux J., Coudert J., and Fellmann N. Effects of the 'live high-train low' method on prooxidant/antioxidant balance on elite athletes. Eur. J. Clin. Nutr. (2008) 10.1038/ejcn.2008.30
10. Prabhakar N.R., Peng Y.J., Kumar G.K., and Pawar A. Altered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneas. Respir. Physiol. Neurobiol. 157 (2007) 148-153
11. Richalet J.P., and Gore C.J. Live and/or sleep high:train low, using normobaric hypoxia. Scand. J. Med. Sci. Sports 18 Suppl. 1 (2008) 29-37