Autoantibodies to glutamic acid decarboxylase (GAD) in focal and generalized epilepsy: A study on 233 patients

Journal of Neuroimmunology

Volumn 211, Issue 1-2, 2009, Pages 120-123

  Errichiello, Luca ^a   Perruolo, Giuseppe ^a   Pascarella, Angelo ^a   Formisano, Pietro ^a   Minetti, Carlo ^b   Striano, Salvatore ^a   Zara, Federico ^b   Striano, Pasquale ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Autoimmunity; Diabetes; Epilepsy; Glutamic acid decarboxylase antibodies

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CARBAMAZEPINE; ETIRACETAM; GLUTAMATE DECARBOXYLASE ANTIBODY; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; TOPIRAMATE; VALPROIC ACID;

ADOLESCENT; ADULT; AGED; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNITY; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; FOCAL EPILEPSY; GENERALIZED EPILEPSY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; TEMPORAL LOBE EPILEPSY;

ADOLESCENT; ADULT; AGED; AUTOANTIBODIES; CHILD; EPILEPSY; FEMALE; GLUTAMATE DECARBOXYLASE; HUMANS; MALE; MIDDLE AGED; RADIOIMMUNOASSAY;

EID: 67349163256     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2009.04.010     Document Type: Article

References (14)

1. Aanstoot H.J., Sigurdsson E., Jaffe M., Shi Y., Christgau S., Grobbee D., Bruining G.J., Molenaar J.L., Hofman A., and Baekkeskov S. Value of antibodies to GAD65 combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood population. Diabetologia 37 (1994) 917-924
2. Batstra M.R., van Driel A., Petersen J.S., van Donselaar C.A., van Tol M.J., Bruining G.J., Grobbee D.E., Dyrberg T., and Aanstoot H.J. Glutamic acid decarboxylase antibodies in screening for autoimmune diabetes: influence of comorbidity, age, and sex on specificity and threshold values. Clin. Chem. 45 (1999) 2269-2272
3. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 30 (1989) 389-399
4. Hsu C.C., Davis K.M., Jin H., Foos T., Floor E., Chen W., Tyburski J.B., Yang C.Y., Schloss J.V., and Wu J.Y. Association of L-glutamic acid decarboxylase to the 70-kDa heat shock protein as a potential anchoring mechanism to synaptic vesicles. J. Biol. Chem. 275 27 (2000) 20822-20828
5. Kwan P., Sills G.J., Kelly K., Butler E., and Brodie M.J. Glutamic acid decarboxylase autoantibodies in controlled and uncontrolled epilepsy: a pilot study. Epilepsy Res. 42 2-3 (2000) 191-195
6. Majoie H.J., de Baets M., Renier W., Lang B., and Vincent A. Antibodies to voltage-gated potassium and calcium channels in epilepsy. Epilepsy Res. 71 2-3 (2006) 135-141
7. McCorry D., Nicolson A., Smith D., Marson A., Feltbower R.G., and Chadwick D.W. An association between type 1 diabetes and idiopathic generalized epilepsy. Ann. Neurol. 59 1 (2006) 204-206
8. McKnight K., Jiang Y., Hart Y., Cavey A., Wroe S., Blank M., Shoenfeld Y., Vincent A., Palace J., and Lang B. Serum antibodies in epilepsy and seizure-associated disorders. Neurology 65 (2005) 1730-1736
9. Peltola J., Kulmala P., Isojärvi J., Saiz A., Latvala K., Palmio J., Savola K., Knip M., Keränen T., and Graus F. Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy. Neurology 55 (2000) 46-50
10. Perucca E. Pharmacoresistance in epilepsy: how should it be defined?. CNS Drugs 10 3 (1998) 171-179
11. Saiz A., Blanco Y., Sabater L., González F., Bataller L., Casamitjana R., Ramió-Torrentà L., and Graus F. Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association. Brain 131 (2008) 2553-2563
12. Sokol D.K., McIntyre J.A., Wagenknecht D.R., Dropcho E.J., Patel H., Salanova V., and da Costa G. Antiphospholipid and glutamic acid decarboxylase antibodies in patients with focal epilepsy. Neurology 62 (2004) 517-518
13. Striano P., Perruolo G., Errichiello L., Formisano P., Beguinot F., Zara F., and Striano S. Glutamic acid decarboxylase antibodies in idiopathic generalized epilepsy and type 1 diabetes. Ann. Neurol. 67 (2008) 127-128
14. Vincent A. Stiff, twitchy or wobbly: are GAD antibodies pathogenic?. Brain 131 (2008) 2536-2537