Propranolol improves cutaneous wound healing in streptozotocin-induced diabetic rats

European Journal of Pharmacology

Volumn 611, Issue 1-3, 2009, Pages 77-84

  Romana Souza, Bruna ^a   Nascimento, Adriana P ^a   Monte Alto Costa, Andréa ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

adrenoceptor; Blood vessel; Collagen fiber; Diabetes mellitus; Nitric oxide; Propranolol

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD68 ANTIGEN; COLLAGEN; CYCLINE; GELATINASE A; GELATINASE B; MYELOPEROXIDASE; NITRIC OXIDE; NITRITE; PROPRANOLOL; STREPTOZOCIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CELL MIGRATION; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; EPITHELIZATION; GRANULATION TISSUE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; MALE; MAST CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STATISTICAL ANALYSIS; STREPTOZOCIN DIABETES; WOUND HEALING IMPAIRMENT;

ANIMALS; CELL PROLIFERATION; COLLAGEN; DIABETES MELLITUS, EXPERIMENTAL; GRANULATION TISSUE; INFLAMMATION; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEOVASCULARIZATION, PHYSIOLOGIC; NITRITES; PROPRANOLOL; RATS; RATS, WISTAR; STREPTOZOCIN; WOUND HEALING; WOUNDS AND INJURIES;

EID: 67349156085     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.03.053     Document Type: Article

References (45)

1. Amadeu T.P., Braune A., Mandarim-de-Lacerda C., Porto L.C., Desmouliere A., and Costa A.M.A. Vascularization pattern in hypertrophic scars and keloids: a stereological analysis. Pathol. Res. Pract. 199 (2003) 469-473
2. Amadeu T.P., Seabra A.B., de Oliveira M.G., and Costa A.M.A. S-nitrosoglutathione-containing hydrogel accelerates rat cutaneous wound repair. J. Eur. Acad. Dermatol. Venereol. 21 (2007) 629-637
3. Andriessen M.P., van Bergen B.H., Spruijt K.I., Go I.H., Schalkwijk J., and van de Kerkhof P.C. Epidermal proliferation is not impaired in chronic venous ulcers. Acta Dermatol. Venereol. 75 (1995) 459-462
4. Anesini C., and Borda E. Modulatory effect of the adrenergic system upon fibroblast proliferation: participation of beta 3-adrenoceptors. Auton. Autacoid. Pharmacol. 22 (2002) 177-186
5. Azizkhan R.G., Azizkhan J.C., Zetter B.R., and Folkman J. Mast cell heparin stimulates migration of capillary endothelial cells in vitro. J. Exp. Med. 152 (1980) 931-944
6. Baddeley A.J., Gundersen H.J., and Cruz-Orive L.M. Estimation of surface area from vertical sections. J. Microsc. 142 (1986) 259-276
7. Bild D.E., Selby J.V., Sinnock P., Browner W.S., Braveman P., and Showstack J.A. Lower-extremity amputation in people with diabetes. Epidemiology and prevention. Diabetes Care 12 (1989) 24-31
8. Bitar M.S., and Labbad Z.N. Transforming growth factor-beta and insulin-like growth factor-I in relation to diabetes-induced impairment of wound healing. J. Surg. Res. 61 (1996) 113-119
9. Brem H., and Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J. Clin. Invest. 117 (2007) 1219-1222
10. Burrow J.W., Koch J.A., Chuang H.H., Zhong W., Dean D.D., and Sylvia V.L. Nitric oxide donors selectively reduce the expression of matrix metalloproteinases-8 and -9 by human diabetic skin fibroblasts. J. Surg. Res. 140 (2007) 90-98
11. Darby I.A., Bisucci T., Hewitson T.D., and MacLellan D.G. Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice. Int. J. Biochem. Cell Biol. 29 (1997) 191-200
12. Delamaire M., Maugendre D., Moreno M., Le Goff M.C., Allannic H., and Genetet B. Impaired leucocyte functions in diabetic patients. Diabet. Med. 14 (1997) 29-34
13. Frank S., Kampfer H., Podda M., Kaufmann R., and Pfeilschifter J. Identification of copper/zinc superoxide dismutase as a nitric oxide-regulated gene in human (HaCaT) keratinocytes: implications for keratinocyte proliferation. Biochem. J. 346 (2000) 719-728
14. Furlan C., Sterin-Borda L., and Borda E. Activation of beta3 adrenergic receptor decreases DNA synthesis in human skin fibroblasts via cyclic GMP/nitric oxide pathway. Cell. Physiol. Biochem. 16 (2005) 175-182
15. Galkowska H., Wojewodzka U., and Olszewski W.L. Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers. Wound Repair Regen. 14 (2006) 558-565
16. Gibran N.S., Jang Y.C., Isik F.F., Greenhalgh D.G., Muffley L.A., Underwood R.A., Usui M.L., Larsen J., Smith D.G., Bunnett N., Ansel J.C., and Olerud J.E. Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus. J. Surg. Res. 108 (2002) 122-128
17. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., and Tannenbaum S.R. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem. 126 (1982) 131-138
18. Gundersen H.J., Bagger P., Bendtsen T.F., Evans S.M., Korbo L., Marcussen N., Moller A., Nielsen K., Nyengaard J.R., Pakkenberg B., et al. The new stereological tools: dissector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 96 (1988) 857-881
19. Hehenberger K., Heilborn J.D., Brismar K., and Hansson A. Inhibited proliferation of fibroblasts derived from chronic diabetic wounds and normal dermal fibroblasts treated with high glucose is associated with increased formation of l-lactate. Wound Repair Regen. 6 (1998) 135-141
20. Hubner G., Brauchle M., Smola H., Madlener M., Fassler R., and Werner S. Differential regulation of pro-inflammatory cytokines during wound healing in normal and glucocorticoid-treated mice. Cytokine 8 (1996) 548-556
21. Hyer S.L., Taylor D., Barham J., Wilson J., Shaw J., and Vince F.P. The effects of propranolol and metoprolol on skin blood flow in diabetic patients. Br. J. Clin. Pharmacol. 23 (1987) 769-771
22. Lerman O.Z., Galiano R.D., Armour M., Levine J.P., and Gurtner G.C. Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production, and response to hypoxia. Am. J. Pathol. 162 (2003) 303-312
23. Levy D.M., Karanth S.S., Springall D.R., and Polak J.M. Depletion of cutaneous nerves and neuropeptides in diabetes mellitus: an immunocytochemical study. Diabetologia 32 (1989) 427-433
24. Li J., Chen J., and Kirsner R. Pathophysiology of acute wound healing. Clin. Dermatol. 25 (2007) 9-18
25. Lobmann R., Ambrosch A., Schultz G., Waldmann K., Schiweck S., and Lehnert H. Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients. Diabetologia 45 (2002) 1011-1016
26. Maruyama K., Asai J., Ii M., Thorne T., Losordo D.W., and D Amore P.A. Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am. J. Pathol. 170 (2007) 1178-1191
27. Masters K.S., Leibovich S.J., Belem P., West J.L., and Poole-Warren L.A. Effects of nitric oxide releasing poly(vinyl alcohol) hydrogel dressings on dermal wound healing in diabetic mice. Wound Repair Regen. 10 (2002) 286-294
28. Meininger C.J., and Zetter B.R. Mast cells and angiogenesis. Semin. Cancer Biol. 3 (1992) 73-79
29. Nascimento A.P., and Costa A.M.A. Overweight induced by high-fat diet delays rat cutaneous wound healing. Br. J. Nutr. 96 (2006) 1069-1077
30. Niu R., Okamoto T., Iwase K., Nomura S., and Mizutani S. Quantitative analysis of matrix metalloproteinases-2 and -9, and their tissue inhibitors-1 and -2 in human placenta throughout gestation. Life Sci. 66 (2000) 1127-1137
31. Reagan-Shaw S., Nihal M., and Ahmad N. Dose translation from animal to human studies revisited. FASEB J. 22 (2008) 659-661
32. Schaeffer P., Bernat A., Arnone M., Manara L., Gallas J.F., Dol-Gleizes F., Millet L., Grosset A., and Herbert J.M. Effect of SR58611A, a potent beta-3 adrenoceptor agonist, on cutaneous wound healing in diabetic and obese mice. Eur. J. Pharmacol. 529 (2006) 172-178
33. Schaffer M.R., Tantry U., Efron P.A., Ahrendt G.M., Thornton F.J., and Barbul A. Diabetes-impaired healing and reduced wound nitric oxide synthesis: a possible pathophysiologic correlation. Surgery 121 (1997) 513-519
34. Schaffer M., Bongartz M., Fischer S., Proksch B., and Viebahn R. Nitric oxide restores impaired healing in normoglycaemic diabetic rats. J. Wound Care 16 (2007) 311-316
35. Schwentker A., Vodovotz Y., Weller R., and Billiar T.R. Nitric oxide and wound repair: role of cytokines?. Nitric Oxide 7 (2002) 1-10
36. Shi H.P., Most D., Efron D.T., Witte M.B., and Barbul A. Supplemental L-arginine enhances wound healing in diabetic rats. Wound Repair Regen. 11 (2003) 198-203
37. Souza B.R., Santos J.S., and Costa A.M.A. Blockade of beta1- and beta2-adrenoceptors delays wound contraction and re-epithelialization in rats. Clin. Exp. Pharmacol. Physiol. 33 (2006) 421-430
38. Stark J.M., van Egmond A.W., Zimmerman J.J., Carabell S.K., and Tosi M.F. Detection of enhanced neutrophil adhesion to parainfluenza-infected airway epithelial cells using a modified myeloperoxidase assay in a microtiter format. J. Virol. Methods 40 (1992) 225-242
39. Varelias A., Cowin A.J., Adams D., Harries R.H., Cooter R.D., Belford D.A., Fitridge R.A., and Rayner T.E. Mitogenic bovine whey extract modulates matrix metalloproteinase-2, -9, and tissue inhibitor of matrix metalloproteinase-2 levels in chronic leg ulcers. Wound Repair Regen. 14 (2006) 28-37
40. Watkins P.J., and Edmonds M.E. Sympathetic nerve failure in diabetes. Diabetologia 25 (1983) 73-77
41. Weller R., and Finnen M.J. The effects of topical treatment with acidified nitrite on wound healing in normal and diabetic mice. Nitric Oxide 15 (2006) 395-399
42. Wetzler C., Kampfer H., Stallmeyer B., Pfeilschifter J., and Frank S. Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair. J. Invest. Dermatol. 115 (2000) 245-253
43. Wild S., Roglic G., Green A., Sicree R., and King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27 (2004) 1047-1053
44. Witte M.B., Thornton F.J., Tantry U., and Barbul A. L-Arginine supplementation enhances diabetic wound healing: involvement of the nitric oxide synthase and arginase pathways. Metabolism 51 (2002) 1269-1273
45. Woessner J.F. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch. Biochem. Biophys. 93 (1961) 440-447