Contemporary issues on clopidogrel therapy

Internal and Emergency Medicine

Volumn 4, Issue 3, 2009, Pages 201-211

  Patti, Giuseppe ^a   Di Sciascio, Germano ^a  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

Author keywords

Acute coronary syndromes; Clopidogrel; Outcome; Percutaneous coronary intervention

Indexed keywords

ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; DRUG DERIVATIVE; TICLOPIDINE;

ACUTE CORONARY SYNDROME; DOSE RESPONSE; HUMAN; OUTCOME ASSESSMENT; REVIEW;

ACUTE CORONARY SYNDROME; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; OUTCOME ASSESSMENT (HEALTH CARE); PLATELET AGGREGATION INHIBITORS; TICLOPIDINE;

EID: 67349144723     PISSN: 18280447     EISSN: 19709366     Source Type: Journal    
DOI: 10.1007/s11739-008-0220-5     Document Type: Review

References (78)

1. A Schömig FJ Neumann A Kastrati 1996 A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents N Engl J Med 334 1084 1089 (Pubitemid 26120185)
2. ME Bertrand HJ Rupprecht P Urban 2000 Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting : the clopidogrel aspirin stent international cooperative study (CLASSICS) Circulation 102 624 629 (Pubitemid 30640661)
3. DL Bhatt ME Bertrand PB Berger 2002 Meta-analysis of randomized and registry comparisons of ticlopidine with clopidogrel after stenting J Am Coll Cardiol 39 9 14 (Pubitemid 34059855)
4. S Yusuf F Zhao SR Mehta 2001 Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation N Engl J Med 345 494 502 (Pubitemid 32758501)
5. SR Mehta S Yusuf RJ Peters 2001 Effects of pre-treatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study Lancet 358 527 533 (Pubitemid 32772726)
6. MS Sabatine CP Cannon CM Gibson 2005 Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation New Engl J Med 352 1179 1189 (Pubitemid 40397259)
7. MS Sabatine CP Cannon CM Gibson 2005 Effect of clopidogrel pre-treatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics: the PCI-CLARITY study JAMA 294 1224 1232 (Pubitemid 41352110)
8. ZM Chen LX Jiang YP Chen 2005 Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial Lancet 366 1607 1621 (Pubitemid 41552416)
9. KA Ault CP Cannon J Mitchell 1999 Platelet activation in patients after an acute coronary syndrome: results from the TIMI-12 trial. Thrombolysis in myocardial infarction J Am Coll Cardiol 33 634 639
10. D Soffer I Moussa KJ Harjai 2003 Impact of angina class on inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention: do we need more aggressive dosing regimens in unstable angina? Catheter Cardiovasc Interv 59 21 25 (Pubitemid 36528793)
11. S Yusuf SR Mehta F Zhao 2003 Early and late effects of clopidogrel in patients with acute coronary syndromes Circulation 107 966 972 (Pubitemid 36258718)
12. FW Verheugt G Montalescot MS Sabatine 2007 Prehospital fibrinolysis with dual antiplatelet therapy in ST-elevation acute myocardial infarction: a substudy of the randomized double blind CLARITY-TIMI 28 trial J Thromb Thrombolysis 23 173 179 (Pubitemid 46564116)
13. SR Steinhubl PB Berger JT Mann III 2002 Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial JAMA 288 2411 2420 (Pubitemid 35340537)
14. SR Steinhubl S Darrah D Brennan 2003 Optimal duration of pre-treatment with clopidogrel prior to PCI: data from the CREDO trial Circulation 108 Suppl I I1742
15. MS Sabatine HN Hamdalla SR Mehta 2008 Efficacy and safety of clopidogrel pre-treatment before percutaneous coronary intervention with and without glycoprotein IIb/IIIa inhibitor use Am Heart J 155 910 917
16. AW Chan DJ Moliterno PB Berger 2003 Triple antiplatelet therapy during percutaneous coronary intervention is associated with improved outcomes including one-year survival J Am Coll Cardiol 42 1188 1195
17. T Szük M Gyöngyösi N Homorodi 2007 Effect of timing of clopidogrel administration on 30-day clinical outcomes: 300-mg loading dose immediately after coronary stenting versus pre-treatment 6 to 24 hours before stenting in a large unselected patient cohort Am Heart J 153 289 295 (Pubitemid 46096860)
18. RK Moore R Lowe AD Grayson 2007 A study comparing the incidence and predictors of creatine kinase MB and troponin T release after coronary angioplasty. Does clopidogrel preloading reduce myocardial necrosis following elective percutaneous coronary intervention? Int J Cardiol 116 93 97 (Pubitemid 46227611)
19. MB Nienhuis JP Ottervanger K Miedema 2006 Pre-treatment with clopidogrel and postprocedure troponin elevation after elective percutaneous coronary intervention Thromb Haemost 95 337 340
20. Y Cadroy JP Bossavy C Thalamas 2000 Early potent antithrombotic effect with combined aspirin and LD of clopidogrel on experimental arterial thrombogenesis in humans Circulation 101 2823 2828 (Pubitemid 30396013)
21. P Gorog CD Ridler GM Rees 1995 Evidence against hypercoagulability in coronary artery disease Thromb Res 79 377 385
22. I Muller M Seyfarth S Rudiger 2001 Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement Heart 85 92 93 (Pubitemid 32973418)
23. ME Leimbach V Peyrou UM Marzec 1999 Single-dose clopidogrel inhibition of platelet adenosine receptor function in patients with atherosclerotic coronary artery disease Circulation 100 Suppl I I681
24. DE Kandzari PB Berger A Kastrati 2004 Influence of treatment duration with a 600-mg dose of clopidogrel before percutaneous coronary revascularization J Am Coll Cardiol 44 2133 2136 (Pubitemid 39576031)
25. A Kastrati J Mehilli H Schuhlen 2004 A clinical trial of abciximab in elective percutaneous coronary intervention after pre-treatment with clopidogrel N Engl J Med 350 232 238 (Pubitemid 38071801)
26. G Patti G Colonna V Pasceri 2005 A randomized trial of high loading dose of clopidogrel for reduction of peri-procedural myocardial infarction in patients undergoing coronary intervention results from the ARMYDA-2 (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) study Circulation 111 2099 2106 (Pubitemid 40577905)
27. G Patti V Pasceri G Di Sciascio 2005 Optimal antiplatelet therapy in patients undergoing percutaneous coronary intervention: new insights from the randomized ARMYDA-2 (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) study Vasc Dis Manag 2 60 62
28. T Cuisset C Frere J Quilici 2006 Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting J Am Coll Cardiol 48 1339 1345 (Pubitemid 44436814)
29. S Silber P Albertsson FF Avilés 2005 Guidelines for percutaneous coronary interventions. The task force for percutaneous coronary interventions of the European society of cardiology Eur Heart J 26 804 847
30. SB King III SC Smith JW Hirshfeld 2008 2007 focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention J Am Coll Cardiol 51 172 209
31. A Kastrati J Mehilli FJ Neumann 2006 Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pre-treatment: the ISAR-REACT 2 randomized trial JAMA 295 1531 1538
32. G Montalescot G Sideris C Meuleman 2006 A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes: the ALBION (Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis) trial J Am Coll Cardiol 48 931 938 (Pubitemid 44292463)
33. N Von Beckerath D Taubert G Pogatsa-Murray 2005 Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect) trial Circulation 112 2946 2950 (Pubitemid 41612296)
34. PL L'Allier G Ducrocq N Pranno 2008 Clopidogrel 600-mg double loading dose achieves stronger platelet inhibition than conventional regimens: results from the PREPAIR randomized study J Am Coll Cardiol 51 1066 1072
35. L Bonello L Camoin-Jau S Arques 2008 Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance J Am Coll Cardiol 51 1404 1411
36. DJ Angiolillo SB Shoemaker B Desai 2007 Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) study Circulation 115 708 716 (Pubitemid 46294761)
37. N von Beckerath A Kastrati A Wieczorek 2007 A double-blind, randomized study on platelet aggregation in patients treated with a daily dose of 150 or 75 mg of clopidogrel for 30 days Eur Heart J 28 1814 1819 (Pubitemid 47236637)
38. SC Smith Jr TE Feldman JW Hirshfeld Jr 2006 ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI Writing Committee to Update the 2001 Guidelines for Percutaneous Coronary Intervention) J Am Coll Cardiol 47 e1 e121 (Pubitemid 43005194)
39. SR Mehta CB Granger JW Eikelboom 2007 Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the OASIS-5 trial J Am Coll Cardiol 50 1742 1751 (Pubitemid 47600591)
40. SV Rao K O'Grady KS Pieper 2005 Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes Am J Cardiol 96 1200 1206 (Pubitemid 41505393)
41. KAA Fox SR Mehta R Peters 2004 Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) trial Circulation 110 1202 1208 (Pubitemid 39202333)
42. P Widimsky Z Motovská S Simek 2008 Clopidogrel pre-treatment in stable angina: for all patients >6 h before elective coronary angiography or only for angiographically selected patients a few minutes before PCI? A randomized multicentre trial PRAGUE-8 Eur Heart J 29 1495 1503
43. Patti G, Colonna G, Pasceri V et al (2007) Is 600 mg in-lab clopidogrel loading equivalent to "upstream" pre-treatment in patients undergoing percutaneous coronary intervention? Results of the ARMYDA-5 (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) randomized trial. Late breaking clinical trials, TCT sessions, October 2007. Available at http://www.cardiosource.com/img/armyda501.ppt
44. JL Anderson CD Adams EM Antman 2007 American College of Cardiology; American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction); American College of Emergency Physicians; Society for Cardiovascular Angiography and Interventions; Society of Thoracic Surgeons; American Association of Cardiovascular and Pulmonary Rehabilitation; Society for Academic Emergency Medicine J Am Coll Cardiol 50 e1 e157 (Pubitemid 47214564)
45. PJ Sharis CP Cannon J Loscalzo 1998 The antiplatelet effects of ticlopidine and clopidogrel Ann Intern Med 129 394 405 (Pubitemid 28402795)
46. A Kastrati N von Beckerath A Joost 2004 Loading with 600 mg clopidogrel in patients with coronary artery disease with and without chronic clopidogrel therapy Circulation 110 1916 1919 (Pubitemid 39331901)
47. Di Sciascio G, Patti G, Colonna G et al (2008) Clopidogrel reloading before percutaneous coronary intervention improves outcome in patients with acute coronary syndromes receiving chronic clopidogrel therapy. Results of the ARMYDA-RELOAD (Antiplatelet Therapy for Reduction of Myocardial Damage During Angioplasty-RELOAD) randomized trial. Late breaking clinical trials, SCAI-ACCi2 sessions, March 2008. Available at http://www.cardiosource.com/ rapidnewssummaries/summary.asp?SumID=242
48. JP Collet J Silvain A Landivier 2008 Dose effect of clopidogrel reloading in patients already on 75-mg maintenance dose: the Reload with Clopidogrel Before Coronary Angioplasty in Subjects Treated Long Term with Dual Antiplatelet Therapy (RELOAD) study Circulation 118 1225 1233
49. PA Gurbel KP Bliden BL Hiatt 2003 Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pre-treatment platelet reactivity Circulation 107 2908 2913 (Pubitemid 36736631)
50. DJ Angiolillo A Fernandez-Ortiz E Bernardo 2004 High clopidogrel loading dose during coronary stenting: effects on drug response and interindividual variability Eur Heart J 25 1903 1910 (Pubitemid 39452607)
51. WC Lau LA Waskell PB Watkins 2003 Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction Circulation 107 32 37 (Pubitemid 36070929)
52. DJ Angiolillo A Fernandez-Ortiz E Bernardo 2006 Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel Arterioscler Thromb Vasc Biol 26 1895 1900 (Pubitemid 44305347)
53. C Frere T Cuisset PE Morange 2008 Effect of cytochrome P450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome Am J Cardiol 101 1088 1093
54. B Giusti AM Gori R Marcucci 2007 Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients Pharmacogenet Genomics 17 1057 1064
55. P Fontana A Dupont S Gandrille 2003 Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects Circulation 108 989 995 (Pubitemid 37048230)
56. VL Serebruany 2007 The "Clopidogrel Resistance" trap Am J Cardiol 100 1044 1046 (Pubitemid 47368116)
57. DJ Angiolillo A Fernandez-Ortiz E Bernardo 2005 Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment Diabetes 54 2430 2435 (Pubitemid 41134272)
58. PA Gurbel KP Bliden K Guyer 2005 Platelet reactivity in patients and recurrent events post-stenting: results of the PREPARE POST-STENTING study J Am Coll Cardiol 46 1820 1826 (Pubitemid 41579802)
59. VL Serebruany SR Steinhubl PB Berger 2005 Variability in platelet responsiveness to clopidogrel among 544 individuals J Am Coll Cardiol 45 246 251 (Pubitemid 40094733)
60. PA Gurbel KP Bliden KA Zaman 2005 Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study Circulation 111 1153 1159 (Pubitemid 40365477)
61. EI Lev RT Patel KJ Maresh 2006 Aspirin and clopidogrel drug response in patients undergoing percutaneous coronary intervention J Am Coll Cardiol 47 27 33
62. T Cuisset C Frere J Quilici 2007 High post-treatment platelet reactivity is associated with a high incidence of myonecrosis after stenting for non-ST elevation acute coronary syndromes Thromb Haemost 97 282 287 (Pubitemid 46592149)
63. AN Buch S Singh P Roy 2007 Measuring aspirin resistance, clopidogrel responsiveness, and post-procedural markers of myonecrosis in patients undergoing percutaneous coronary intervention Am J Cardiol 99 1518 1522 (Pubitemid 46770633)
64. T Cuisset M Hamilos J Sarma 2008 Relation of low response to clopidogrel assessed with point-of-care assay to peri-procedural myonecrosis in patients undergoing elective coronary stenting for stable angina pectoris Am J Cardiol 101 1700 1703
65. T Cuisset C Frere J Quilici 2006 High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome J Thromb Haemost 4 542 549
66. T Geisler H Langer M Wydymus 2006 Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation Eur Heart J 27 2420 2425 (Pubitemid 44522148)
67. W Hochholzer D Trenk HP Bestehorn 2006 Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement J Am Coll Cardiol 48 1742 1750 (Pubitemid 44648629)
68. G Patti A Nusca F Mangiacapra 2008 Point-of-care measurement of clopidogrel responsiveness predicts clinical outcome in patients undergoing percutaneous coronary intervention. Results of the ARMYDA-PRO (Antiplatelet Therapy for Reduction of MYocardial Damage During Angioplasty-Platelet Reactivity Predicts Outcome) study J Am Coll Cardiol 52 1128 1133
69. S Matetzky B Shenkman V Guetta 2003 Clopidogrel resistance in patients with acute coronary syndrome is associated with increased risk of recurrent cardiovascular events Circulation 108 501
70. KP Bliden J DiChiara US Tantry 2007 Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary intervention J Am Coll Cardiol 49 657 666
71. MJ Price S Endemann RR Gollapudi 2008 Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation Eur Heart J 29 992 1000
72. PA Gurbel KP Bliden W Samara 2005 Clopidogrel effect on platelet reactivity in patients with stent thrombosis: results of the CREST study J Am Coll Cardiol 46 1827 1832 (Pubitemid 41579803)
73. I Mueller F Besta C Schulz 2003 Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement Thromb Haemost 89 783 787 (Pubitemid 36603418)
74. R Klamroth S Hoffmann D Andresen 2004 Clopidogrel resistance and aspirin resistance-a cause of coronary artery stent thrombosis? Blood 104 104B
75. N Ajzenberg P Aubry MG Huisse 2005 Enhanced shear-induced platelet aggregation in patients who experience subacute stent thrombosis J Am Coll Cardiol 45 1753 1756 (Pubitemid 40779851)
76. P Wenaweser J Dorffler-Melly K Imboden 2005 Stent thrombosis is associated with an impaired response to antiplatelet therapy J Am Coll Cardiol 45 1748 1752 (Pubitemid 40779850)
77. EI Lev CL Alviar ME Arikan 2007 Platelet reactivity in patients with subacute stent thrombosis compared with non-stent-related acute myocardial infarction Am Heart J 153 41.e1 41.e6
78. P Buonamici R Marcucci A Migliorini 2007 Impact of platelet reactivity after clopidogrel administration on drug-eluting stent thrombosis J Am Coll Cardiol 49 2312 2317 (Pubitemid 46891710)