Anticonvulsant and behavioural actions of Myristica fragrans seeds

Indian Journal of Pharmacology

Volumn 34, Issue 5, 2002, Pages 332-338

  Sonavane, G S ^a   Palekar, R C ^a   Kasture, V S ^a   Kasture, Sanjay B ^a  

^a Department of Pharmacology   (India)

Author keywords

Antiepileptic; Central nervous system effects; MES

Indexed keywords

ACETONE; DIAZEPAM; HALOPERIDOL; HEXANE; LITHIUM SULFATE; NEUROLEPTIC AGENT; NUTMEG EXTRACT; PENTETRAZOLE; PENTOBARBITAL; PETROLEUM ETHER; PICROTOXIN; PILOCARPINE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CATALEPSY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DOPAMINERGIC TRANSMISSION; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; ELECTRIC SHOCK; EPILEPTIC STATE; GRAND MAL SEIZURE; INHIBITION KINETICS; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; NUTMEG; PETIT MAL; PLANT SEED; SEDATION; SEIZURE; SLEEP INDUCTION; STATISTICAL SIGNIFICANCE; TOXICITY TESTING;

EID: 0036797527     PISSN: 02537613     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. McNamara JO. Drugs effective in the treatment of the epilepsies. In: Goodman and Gillman's The Pharmacological Basis of Therapeutics. 9th edn. Hardman JG, Limbird JE, Molinoff PB, Ruddon RW, Gilman AG, eds. New York: McGraw Hill; 1999 p. 461-86.
2. Sonavane GS, Sarveiya VP, Kasture VS, Kasture SB. Anxiogenic activity of Myristica fragrans seeds. Pharmacol Biochem Behav 2002;71:247-52.
3. Turner RA. Screening procedures in Pharmacology. New York: Academic Press; 1972. p. 22-41.
4. Dunham MW, Miya TS. A note on a simple apparatus for detecting neurological deficit in rats and mice. J Am Pharm Ass Sci 1957;46:208-9.
5. Swinyard EA, Brown WC, Goodman LS. Comparative assay of antiepileptic drugs in mice and rats. J Pharmacol Exp Ther 1952;106:319-30.
6. Leewanich P, Tohda M, Matsumoto K, Subhadirsakul S, Takayama H, Watanabe H, et al. Behavioural studies on alkaloids extracts from the leaves of Hunteria zeylanica. Biol Pharm Bull 1996;19:394-9.
7. Patel S, Meldrum BS, Fine A. Susceptibility to pilocarpine-induced seizures in rats increases with age. Behav Brain Res 1988:31:165-7.
8. 3 receptor antagonists on neuroleptic-induced catalepsy in mice. Neuropharmacol 1995;34:97-9.
9. Ha JH, Lee DU, Lee JT, Kim JS, Yong CS, Kim JA, et al. 4-Hydroxybenzaldehyde from Gastrodia elata as active in the antioxidation and GABAergic neuromodulation of the rat brain. J Ethnopharmacol 2000;73:329-33.
10. Ormandy GC, Jope RS, Snead OC. Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats. Exp Neurol 1989;106:172-80.
11. Sherman WR, Honchar MP, Honsel LY. Detection of receptor linked phosphoinositide metabolism in brain of lithium treated rats: In Bleasdale TE, Eichborg J, Hauser C, eds. Inositol and Phosphoinositides: Metabolism and regulation. Clifton NJ: Humana Press; 1989. p. 49-65.
12. Sanberg PR. Haloperidol-induced catalepsy is mediated by postsynaptic dopamine receptors. Nature 1980;284:472-3.
13. 2 dopamine receptors in neuroleptic catalepsy. Eur J Pharmacol 1990;182:327-34.
14. Vidali M, Fregnan GB. Effect of different CNS-acting drugs on catalepsy induced by neuroleptics. Curr Ther Res 1979;25:544-56.
15. Pires JGP, Ramage AG, Silva SR, Futuro-Neto HA. Effects of the 5-HT receptor antagonists cyanopindolol, ICI 169369, cisapride and granisetron on neuroleptic-induced catalepsy in mice. Braz J Med Biol Res 1993;26:847-52.
16. 1 receptors. Eur J Pharmacol 1990;182:245-51.
17. Dazzi L, Serra M, Porceddu ML, Sanna A, Chessa MF, Biggio G. Enhancement of basal and pentylenetetrazol (PTZ)-stimulated dopamine release in the brain of freely moving rats by PTZ-induced kindling. Synapse 1997;4:351-8.
18. Somani RS, Kasture VS, Kasture SB. Haloperidol inhibits (-) bicuculline-induced seizures and bicuculline potentiates haloperidol-induced catalepsy in mice. Indian J Pharmacol 1999;31:434-6.
19. Kuczenski R, Segal DS. In vivo measures of monoamines during amphetamine induced behaviors in rats. Prog Neuropsychopharmacol Biol Psychiatry 1990:14:537-50.