Evaluation of the effects and mechanisms of action of flutriafol, a triazole fungicide, on striatal dopamine release by using in vivo microdialysis in freely moving rats

Ecotoxicology and Environmental Safety

Volumn 72, Issue 5, 2009, Pages 1565-1571

  Santana, M B ^a   Rodrigues, K J A ^a   Duran R ^b   Alfonso, M ^b   Vidal, L ^b   Campos, F ^b   De Oliveira, I M ^b   Faro, L R F ^b  

^a FEDERAL UNIVERSITY OF PARÁ   (Brazil)

^b UNIVERSITY OF VIGO   (Spain)

Author keywords

Brain microdialysis; Dopamine; Flutriafol; HPLC EC; Striatum; Triazole fungicide

Indexed keywords

CALCIUM ION; DOPAMINE; DOPAMINE TRANSPORTER; FLUTRIAFOL; FUNGICIDE; NOMIFENSINE; RESERPINE; SODIUM ION; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

BRAIN; FUNGICIDE; LIQUID CHROMATOGRAPHY; RODENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ELECTROCHEMICAL DETECTION; EXOCYTOSIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MICRODIALYSIS; NONHUMAN; RAT;

ANIMALS; BASAL GANGLIA; CALCIUM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; ELECTROCHEMICAL TECHNIQUES; EXOCYTOSIS; FEMALE; FUNGICIDES, INDUSTRIAL; LOCOMOTION; MICRODIALYSIS; NOMIFENSINE; POTASSIUM; RATS; RATS, SPRAGUE-DAWLEY; RESERPINE; SODIUM; SODIUM CHANNEL BLOCKERS; TETRODOTOXIN; TIME FACTORS; TRIAZOLES;

ANIMALIA; RATTUS;

EID: 67349139616     PISSN: 01476513     EISSN: 10902414     Source Type: Journal    
DOI: 10.1016/j.ecoenv.2009.01.004     Document Type: Article

References (29)

1. Crofton K.M. A structure-activity relationship for the neurotoxicity of triazole fungicides. Toxicol. Lett. 84 (1996) 155-159
2. Crofton K.M., Boncek V.M., and Reiter L.W. Hyperactivity induced by triadimefon, a triazole fungicide. Fund. Appl. Toxicol. 10 (1988) 459-465
3. Crofton K.M., Boncek V.M., and Macphail R.C. Evidence for monoaminergic involvement in triadimefon-induced hyperactivity. Psychopharmacology 97 (1989) 326-330
4. Durán R., Alfonso M., and Arias B. Determination of biogenic amines in rat brain dialysates by high performance liquid chromatography. J. Liquid Chromatogr. Relat. Tech. 21 (1998) 2799-2811
5. Elverfors A., Pileblad E., Lagerkvist S., Bergquist F., Jonason J., and Nissbrandt H. 3-Methoxytyramine formation following monoamine oxidase inhibition is a poor index of dendritic DA release in the substantia nigra. J. Neurochem. 69 (1997) 1684-1692
6. EPA-US Environmental Protection Agency Pesticide Monitoring, Phase II Fact Sheet Series 7 (of 14), Washington, 1991.
7. Gagnaire F., and Micillino J.C. Effects of triadimefon on extracellular dopamine, DOPAC, HVA and 5-HIAA in adult rat striatum. Toxicology 217 (2006) 91-104
8. Gluck M.R., and Zeevalk G.D. Inhibition of brain mitochondrial respiration by dopamine and its metabolites: implications for Parkinson's disease and catecholamine-associated diseases. J. Neurochem. 91 (2004) 788-795
9. Heeringa M.J., and Abercrombie E.D. Biochemistry of somatodendritic dopamine release in substantia nigra: an in vivo comparison with striatal dopamine release. J. Neurochem. 65 (1995) 192-200
10. Hill D., Ikaiddi M., Mazzio E., and Soliman K.F. The neurochemical basis for the behavioral effects of triadimefon. Ann. N. Y. Acad. Sci. 914 (2000) 336-353
11. Ikaiddi M.U., Akunne H.C., and Soliman K.F. Behavioral and neurochemical effects of acute and repeated administration of triadimefon in the male rat. Neurotoxicology 18 (1997) 771-780
12. Kannari K., Tanaka H., Maeda T., Tomiyama M., Suda T., and Matsunaga M. Reserpine pretreatment prevents increases in extracellular striatal dopamine following L-DOPA administration in rats with nigrostriatal denervation. J. Neurochem. 74 (2000) 263-269
13. Leviel V. The reverse transporter of DA, What the physiological significance?. Neurochem. Int. 38 (2001) 83-106
14. Meiergerd S.M., and Schenk J.O. Kinetic evaluation of the commonality between the site(s) of action of cocaine and some other structurally similar and dissimilar inhibitors of the striatal transporter for DA. J. Neurochem. 63 (1994) 1683-1692
15. Menegola E., Broccia M.L., Di Renzo F., Prati M., and Giavini E. In vitro teratogenic potential of two antifungal triazoles: triadimefon and triadimenol. In Vitro Cell Dev. Biol. Anim. 36 (2000) 88-95
16. Middleton M.C., Milne C.M., Moreland S., and Hasmall R.S. Ovulation in rats is delayed by a substituted triazole. Toxicol. Appl. Pharmacol. 83 (1986) 230-239
17. Milne C.M., Hasmall R.S., Russel A., Watson S.C., Vaughan Z., and Middelton M.C. Reduced estradiol production by a substituted triazole results in delayed ovulation in rats. Toxicol. Appl. Pharmacol. 90 (1987) 427-435
18. Moser V.C., Cheek B.M., and Macphail R.C. A multidisciplinary approach to toxicological screening. III. Neurobehavioral toxicity. J. Toxicol. Environ. Health 45 (1995) 173-210
19. Moser V.C., Barone Jr. S., Smialowicz R.J., Harris M.W., Davis B.J., Overstreet D., Mauney M., and Chapin R.E. The effects of perinatal tebuconazole exposure on adult neurological, immunological, and reproductive function in rats. Toxicol. Sci. 62 (2001) 339-352
20. Paxinos G., and Watson C. The rat brain. Stereotaxic Coordinates. fourth ed (1986), Academic Press, New York
21. Perkins A.N., Eckerman D.A., and Macphail R.C. Discriminative stimulus properties of triadimefon: comparison with methylphenidate. Pharmacol. Biochem. Behav. 40 (1991) 757-761
22. PSD. Pesticides Safety Directorate, 1996. Food and Environment Protection Act, 1985, Part III. Evaluation on: Flutriafol. October.
23. Reeves R., Thiruchelvam M., Richfield E.K., and Cory-Slechta D.A. Behavioral sensitisation and long-term neurochemical alterations associated with the fungicide triadimefon. Pharmacol. Biochem. Behav. 76 (2003) 315-326
24. Reeves R., Thiruchelvam M., and Cory-Slechta D.A. Development of behavioural sensitisation to the cocaine-like fungicide triadimefon is prevented by AMPA, NMDA, DA D1 but not DA D2 receptor antagonists. Toxicol. Sci. 79 (2004) 123-136
25. Tolwani R.J., Jakowec M.W., Petzinger G.M., Green S., and Waggie K. Experimental models of Parkinson's disease: insights from many models. Lab. Anim. Sci. 49 (1999) 363-371
26. Walker Q.D., and Mailman R.B. Triadimefon and triadimenol: effects on Monoamine uptake and release. Toxicol. Appl. Pharmacol. 139 (1996) 227-233
27. Walker Q.D., Lewis M.H., Crofton K.M., and Mailman R.B. Triadimefon, a triazole fungicide, induces stereotyped behavior and alters monoamine metabolism in rats. Toxicol. Appl. Pharmacol. 102 (1990) 474-485
28. Wieczorek W.J., and Kruk Z.L. A quantitative comparison on the effects of benztropine, cocaine and nomifensine on electrically evoked DA overflow and rate of re-uptake in the caudate putamen and nucleus accumbens in the rat brain slice. Brain Res. 657 (1994) 42-50
29. Zarn J.A., Brüschweiller B.J., and Schlatter J.R. Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14α-demethylase and aromatase. Environ. Health Perspect. 111 (2003) 255-261