Expression and prognostic significance of human growth and transformation-dependent protein in gastric carcinoma and gastric adenoma

Human Pathology

Volumn 40, Issue 7, 2009, Pages 975-981

  Cho, Young Eun ^a   Kim, Jee Youn ^a   Kim, Youn Wha ^a   Park, Jae Hoon ^a   Lee, Sun ^a  

^a Biomedical Science Institute   (South Korea)

Author keywords

HGTD P; Immunohistochemistry; Stomach neoplasm

Indexed keywords

KI 67 ANTIGEN;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER GROWTH; CANCER STAGING; CELL PROLIFERATION; CYTOPLASM; DISEASE CLASSIFICATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE METAPLASIA; LAUREN CLASSIFICATION; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; STOMACH; STOMACH ADENOMA; STOMACH CANCER; STOMACH CARCINOMA; STOMACH EPITHELIUM;

ADENOCARCINOMA; ADENOMA; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; KAPLAN-MEIERS ESTIMATE; KI-67 ANTIGEN; MALE; MEMBRANE PROTEINS; METAPLASIA; MIDDLE AGED; MITOCHONDRIAL PROTEINS; PROGNOSIS; STOMACH NEOPLASMS;

EID: 67349139270     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2008.12.007     Document Type: Article

References (18)

1. Harris A.L. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2 (2002) 38-47
2. Semenza G.L., Agani F., Feldser D., et al. Hypoxia, HIF-1, and the pathophysiology of common human diseases. Adv Exp Med Biol 475 (2000) 123-130
3. Semenza G. Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol 64 (2002) 993-998
4. Lee M.J., Kim J.Y., Suk K., and Park J.H. Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. Mol Cell Biol 24 (2004) 3918-3927
5. Charpentier A.H., Bednarek A.K., Daniel R.L., et al. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. Cancer Res 60 (2000) 5977-5983
6. American Joint committee on Cancer. AJCC cancer staging manuel. 5th ed. (1997), Lippincott, Philadelphia
7. Lauren P. The two histological main types of gastric carcinoma. Diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 64 (1965) 31-49
8. Cho Y.E., Ko J.H., Kim Y.J., Yim J.H., Kim S.U., and Park J.H. mHGTD-P mediates hypoxic neuronal cell death via the release of apoptosis-inducing factor. Neurosci Lett 416 (2007) 144-149
9. Cabuk D., Basaran G., Celikel C., et al. Vascular endothelial growth factor, hypoxia-inducible factor 1 alpha and CD34 expressions in early-stage gastric tumors: relationship with pathological factors and prognostic impact on survival. Oncology 72 (2007) 111-117
10. Kim J.Y., Kim S.M., Ko J.H., Yim J.H., Park J.H., and Park J.H. Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades. FEBS letters 580 (2006) 3270-3275
11. Kothari S., Cizeau J., McMillan-Ward E., et al. BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF. Oncogene 22 (2003) 4734-4744
12. Sowter H.M., Ratcliffe P.J., Watson P., Greenberg A.H., and Harris A.L. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res 61 (2001) 6669-6673
13. Burton T.R., Henson E.S., Baijal P., Eisenstat D.D., and Gibson S.B. The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: implications for glioblastoma multiforme tumor cell survival under hypoxia. Int J Cancer 118 (2006) 1660-1669
14. Schmidt-Kastner R., Aquirre Chen C., Kietzmann T., Saul I., Busto R., and Ginsberg M.D. Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus. Brain Res 1001 (2004) 133-142
15. Tahara E., Semba S., and Tahara H. Molecular biological observations in gastric cancer. Semin Oncol 23 (1996) 307-315
16. Nardone G., Rocco A., and Malfertheiner P. Review article; Helicobacter pylori and molecular events in precancerous gastric lesions. Aliment Pharmacol Ther 20 (2004) 261-270
17. Diehl J.T., Hermann R.E., Cooperman A.M., and Hoerr S.O. Gastric carcinoma. A ten-year review. Ann Surg 198 (1983) 9-12
18. Hall P.A., Levison D.A., Woods A.L., et al. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections; an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 162 (1990) 285-294