Hydroxylated PCB metabolites (OH-PCBs) in archived serum from 1950-60s California mothers: A pilot study

Environment International

Volumn 35, Issue 6, 2009, Pages 937-942

  Park, J S ^a   Petreas, M ^a   Cohn, B A ^b   Cirillo, P M ^b   Factor Litvak, P ^c  

^a CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b Women's/Children's Health Res Ctr   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

California; Hydroxylated PCB m etabolites; Maternal blood serum; OH PCBs; PCBs; Polychlorinated biphenyls

Indexed keywords

BIOMOLECULES; BODY FLUIDS; HYDROXYLATION; METABOLITES; POLYCHLORINATED BIPHENYLS;

AVERAGE CONCENTRATION; CALIFORNIA; HYDROXYLATED PCB M ETABOLITES; MATERNAL BLOODS; METHYL DERIVATIVES; OH-PCBS; ORGANOCHLORINE CONTAMINANTS; PRIMARY METABOLITE;

ORGANIC POLLUTANTS;

2,2',3',4,4',5 HEXACHLOROBIPHENYL 3 OL; 2,2',3',4,4',5,5' HEPTACHLOROBIPHENYL 3 OL; 2,2',3,3',4',5 HEXACHLOROBIPHENYL 4 OL; 2,2',3,3',4',5,5' HEPTACHLOROBIPHENYL 4 OL; 2,2',3,4',5,5',6 HEPTACHLOROBIPHENYL 4 OL; 2,2',4,4',5,5' HEXACHLOROBIPHENYL 3 OL; 2,3,3',4',5 PENTACHLOROBIPHENYL 4 OL; POLYCHLORINATED BIPHENYL; POLYCHLORINATED BIPHENYL DERIVATIVE; UNCLASSIFIED DRUG;

CONCENTRATION (COMPOSITION); DETECTION METHOD; MEASUREMENT METHOD; METABOLITE; PCB; SERUM;

ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); FEMALE; HUMAN; HYDROXYLATION; MATERNAL BLOOD; METABOLITE; PILOT STUDY; PRIORITY JOURNAL; THYROID FUNCTION; UNITED STATES;

CALIFORNIA; NORTH AMERICA; UNITED STATES;

ANIMALIA;

EID: 67349124113     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2009.04.002     Document Type: Article

References (40)

1. Ballschmitter K., and Zell M. Analysis of polychlorinated biphenyls (PCB) by glass capillary gas chromatography. Composition of technical Aroclor- and Chlophen-PCB mixtures. Fresenius' J Anal Chem 302 (1980) 20-31
2. Bignert A., Olsson M., Persson W., Jensen S., Zakrisson S., Litzen K., et al. Temporal trends of organochlorines in Northern Europe, 1967-1995. Relation to global fractionation, leakage from sediments and international measures. Environ Pollut 99 (1998) 177-198
3. Builee T.L., and Hatherill J.R. The role of polyhalogenated aromatic hydrocarbons on thyroid hormone disruption and cognitive function: a review. Drug Chem Toxicol 27 (2004) 405-424
4. Campbell L.M., Muir D.C.G., Whittle D.M., Backus S., Norstrom R.J., and Fisk A.T. Hydroxylated PCBs and other chlorinated phenolic compounds in lake trout (Salvelinus namaycush) blood plasma from the Great Lakes Region. Environ Sci Tech 37 (2003) 1720-1725
5. Codru N., Schymura M.J., and Negoita S. The Akwesasne Task Force on the Environment, Rej R, Carpenter DO. Diabetes in relation to serum levels of polychlorinated biphenyls and chlorinated pesticides in adult Native Americans. Environ Health Perspect 115 (2007) 1442-1447
6. Enomoto T., Nishio Y., Hasegawa J., Katou H., Miura H., Masuda M., et al. The transfer of hydroxylated PCBs (HO-PCBs) across the human placenta and into maternal milk, and their relationship to thyroid hormones of human newborn period. Organohalog Compd (2007) 2022-2025
7. Fängström B., Athanasiadou M., Grandjean P., Weihe P., and Bergman Å. Hydroxylated PCB metabolites and PCBs in serum from pregnant Faroese women. Environ Health Perspect 110 (2002) 895-899
8. Fängström B., Hovander L., Bignert A., Athanassiadis I., Linderholm L., Grandjean P., et al. Concentrations of polybrominated diphenyl ethers, polychlonnated biphenyls, and polychlorobiphenylols in serum from pregnant Faroese women and their children 7 years later. Environ Sci Technol 39 (2005) 9457-9463
9. Ginsberg G., Hattis D., and Sonawane B. Incorporating pharmacokinetic differences between children and adults in assessing children's risks to environmental toxicants. Toxicol Appl Pharmacol 198 (2004) 164-183
10. Guvenius D.M., Aronsson A., Ekman-Ordeberg G., Bergman Å., and Noren K. Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols, and pentachlorophenol. Environ Health Perspect 111 (2003) 1235-1241
11. Hasegawa J., Matsuda M., Ohnishi H., Enomoto T., Kwawano M., and Wakimoto T. PCBs and hydroxylated PCB metabolites in the tissues of wild birds and fish prey from Japan. Organohalog Compd 69 (2007) 1495-1498
12. Hovander L., Malmberg T., Athanasiadou M., Athanassiadis L., Rahm S., Bergman Å., et al. Identification of hydroxylated PCB metabolites and other phenolic halogenated pollutants in human blood plasma. Arch Environ Contam Toxicol 42 (2002) 105-117
13. James R.A., Hertz-Picciotto I., Willman E., Keller J.A., and Charles M.J. Determinants of serum polychlorinated biphenyls and organochlorine pesticides measured in women from the Child Health and Development Study cohort, 1963-1967. Environ Health Perspect 110 (2002) 617-624
14. Kenet T., Froemke R.C., Schreiner C.E., Pessah I.N., and Merzenich M.M. Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex. Proc Natl Acad Sci U S A 104 (2007) 7646-7651
15. Lans M.C., Klassonwehler E., Willemsen M., Meussen E., Safe S., and Brouwer A. Structure-Dependent, competitive interaction of hydroxy-polychlorobiphenyls, hydroxy-dibenzo-p-dioxins and hydroxy-dibenzofurans with human transthyretin. Chem-Biol Interact 88 (1993) 7-21
16. Letcher R.J., Klasson W.E., and Bergman Å. Methylsulfon and hydroxylated metabolites of polychlorinated biphenyls. In: Part K., and Paasivirta J. (Eds). Handbook of environmental chemistry. New types of persistent halogenated compounds vol. 3 (2000), Springer-Verlag, Berlin
17. Linderholm L., Park J.S., Kocan A., Trnovec T., Athanasiadou M., Bergman K., et al. Maternal and cord serum exposure to PCB and DDE methyl sulfone metabolites in eastern Slovakia. Chemosphere 69 (2007) 403-410
18. Linderholm L., Masuda Y., Athanansiadou M., and Bergman Å. PCB and PCB metabolites in serum from Yusho patients 37 years after the accident. Organohalog Compd 69 (2007) 2141-2144
19. Longnecker M.P., Klebanoff M.A., Gladen B.C., and Berendes H.W. Serial levels of serum organochlorines during pregnancy and postpartum. Arch Environ Health 54 (1999) 110-114
20. Longnecker M.P., Klebanoff M.A., Brock J.W., Zhou H.B., and Project C.P. Polychlorinated biphenyl serum levels in pregnant subjects with diabetes. Diabetes Care 24 (2001) 1099-1101
21. Longnecker M.P., Hoffman H.J., Klebanoff M.A., Brock J.W., Zhou H.B., Needham L., et al. In utero exposure to polychlorinated biphenyls and sensorineural hearing loss in 8-year-old children. Neurotoxicol Teratol 26 (2004) 629-637
22. Malmberg T., Hoogstraate J., Bergman Å., and Wehler E.K. Pharmacokinetics of two major hydroxylated polychlorinated biphenyl metabolites with specific retention in rat blood. Xenobiotica 34 (2004) 581-589
23. Meerts I., Assink Y., Cenijn P.H., van den Berg J.H.J., Weijers B.M., Bergman Å., et al. Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat. Toxicol Sci 68 (2002) 361-371
24. Negishi T., Takahashi M., and Tashiro T. Alterations in gene expression by exposure to hydroxylated polychlorinated biphenyls in developing rat brain. Organohalog Compd 69 (2007) 424-427
25. Norén K., and Meironyté D. Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years. Chemosphere 40 (2000) 1111-1123
26. Ohta C., Haraguchi K., Kato Y., Matsuoka M., Endo T., and Koga N. The distribution of metabolites of 2,2,3,4,5,6-heptachlorobiphenyl (CB183) in rats and guinea pigs. Organohalog Compd 69 (2007) 1761-1764
27. Otake T., Yoshinaga J., Enomoto T., Matsuda M., Wakimoto T., Ikegami M., et al. Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites. Environ Res 105 (2007) 240-246
28. Park, HY, Park, JS, Sovcikova, E, Kocan, A, Trnovec, T, Linderholm, L, et al. Exposure to hydroxylated polychlorinated biphenyls (OH-PCBs) in the prenatal period and subsequent neurodevelopment in eastern Slovakia. Environ Health Perspect 2009a.
29. Park J.S., Kalantzi O.I., Kopec D., and Petreas M. Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) in livers of harbor seals (Phoca vitulina) from San Francisco Bay, California and Gulf of Maine. Marin Environ Res 67 (2009) 129-135
30. Park J.S., Linderholm L., Charles M.J., Athanasiadou M., Petrik J., Kocan A., et al. Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBs) in pregnant women from eastern Slovakia. Environ Health Perspect 115 (2007) 20-27
31. Park J.S., Bergman Å., Linderholm L., Athanasiadou M., Charles M.J., Kocan A., et al. Placental transfer of PCBs and their metabolites (OH-PCBs) in eastern Slovakia birth cohort. Chemosphere 70 (2008) 1676-1684
32. Richthoff J., Rylander L., Jonsson B.A.G., Akesson H., Hagmar L., Nilsson-Ehle P., et al. Serum levels of 2,2 ′,4,4 ′,5,5 ′-hexachlorobiphenyl (CB-153) in relation to markers of reproductive function in young males from the general Swedish population. Environ Health Perspect 111 (2003) 409-413
33. Rignell-Hydbom A., Rylander L., Giwercman A., Jönsson B.A.G., Nilsson-Ehle P., and Hagmar L. Exposure to CB-153 and p,p′-DDE and male reproductive function. Hum Reprod 19 (2004) 2066-2075
34. Rogers E., Petreas M., Park J.S., Zhao G.M., and Charles M.J. Evaluation of four capillary columns for the analysis of organochlorin pesticides, polychlorinated biphenyls, and polybrominated diphenyl ethers in human serum for epidemiological studies. J Chromatogr B 813 (2004) 269-285
35. Sandau, C.D. Analytical chemistry of hydroxylated metabolites of PCBs and other halogenated phenolic compounds in blood and their relationship to thyroid hormone and retinol homeostasis in humans and polar bears. Carleton University, Ottawa, Ontario. Ph.D. Dissertation; 2000. p. 39-44.
36. Sandau C.D., Ayotte P., Dewailly E., Duffe J., and Norstrom R.J. Analysis of hydroxylated metabolites of PCBs (OH-PCBs) and other chlorinated phenolic compounds in whole blood from Canadian Inuit. Environ Health Perspect 108 (2000) 611-616
37. Soechitram S.D., Athanasiadou M., Hovander L., Bergman Å., and Sauer P.J.J. Fetal exposure to PCBs and their hydroxylated metabolites in a Dutch cohort. Environ Health Perspect 112 (2004) 1208-1212
38. Ueno D., Darling C., Alaee M., Campbell L., Pacepavicius G., Teixeira C., et al. Detection of hydroxylated polychlorinated biphenyls (OH-PCBs) in the abiotic environment: surface water and precipitation from Ontario, Canada. Environ Sci Technol 41 (2007) 1841-1848
39. Weihe P., Hoppe H.W., and Grandjean P. Sustained high concentrations of PCBs in Faroese pregnant women despite dietary intervention. Organohalogen Cmpds 63 (2003) 389-392
40. Weiss J., Wallin E., Axmon A., Joensson B.A.G., Aakesson H., Janak K., et al. Hydroxy-PCBs, PBDEs, and HBCDDs in serum from an elderly population of Swedish fishermen's wives and associations with bone density. Environ Sci Technol 40 (2006) 6282-6289