Association Between Sodium- and Potassium-Activated Adenosine Triphosphatase α Isoforms and Bipolar Disorders

Biological Psychiatry

Volumn 65, Issue 11, 2009, Pages 985-991

  Goldstein, Inbal ^a   Lerer, Elad ^b   Laiba, Efrat ^b   Mallet, Jacques ^c   Mujaheed, Mustafa ^d   Laurent, Claudine ^e   Rosen, Haim ^a   Ebstein, Richard P ^a,b   Lichtstein, David ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HERZOG HOSPITAL   (Israel)

^c Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs   (France)

^d Palestinian Research Center for Genetics of Mental Disorders   (Palestine)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Affective disorders; bipolar disorders; family based study; genetic association; K+ ATPase; Na+; SNPs

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ISOENZYME; SODIUM POTASSIUM ACTIVATED ADENOSINE TRIPHOSPHATASE ALPHA; SODIUM POTASSIUM ACTIVATED ADENOSINE TRIPHOSPHATASE ALPHA1; SODIUM POTASSIUM ACTIVATED ADENOSINE TRIPHOSPHATASE ALPHA2; SODIUM POTASSIUM ACTIVATED ADENOSINE TRIPHOSPHATASE ALPHA3; UNCLASSIFIED DRUG;

ARTICLE; ATP1A1 GENE; ATP1A2 GENE; ATP1A3 GENE; BIPOLAR I DISORDER; BIPOLAR II DISORDER; FEMALE; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

BIPOLAR DISORDER; DNA MUTATIONAL ANALYSIS; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN ISOFORMS; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 67349124103     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2008.10.033     Document Type: Article

References (48)

1. Sklar P., Smoller J.W., Fan J., Ferreira M.A., Perlis R.H., Chambert K., et al. Whole-genome association study of bipolar disorder. Mol Psychiatry 13 (2008) 558-569
2. Mynett-Johnson L., Murphy V., McCormack J., Shields D.C., Claffey E., Manley P., et al. Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3). Biol Psychiatry 44 (1998) 47-51
3. Jones I., Kent L., and Craddock N. Genetics of affective disorder. In: McGuffin P., Owen M., and Gottesman I. (Eds). Psychiatric Genetics and Genomics (2004), Oxford University Press, Oxford, UK 211-245
4. McGuffin P., Rijsdijk F., Andrew M., Sham P., Katz R., and Cardno A. The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Arch Gen Psychiatry 60 (2003) 497-502
5. Farmer A., Elkin A., and McGuffin P. The genetics of bipolar affective disorder. Curr Opin Psychiatry 20 (2007) 8-12
6. Serretti A., and Mandelli L. The genetics of bipolar disorder: Genome 'hot regions,' genes, new potential candidates and future directions. Mol Psychiatry 13 (2008) 742-771
7. Scheiner-Bobis G. The sodium pump. Its molecular properties and mechanics of ion transport. Eur J Biochem 269 (2002) 2424-2433
8. Xie Z., and Cai T. Na+-K+-ATPase-mediated signal transduction: From protein interaction to cellular function. Mol Interv 3 (2003) 157-168
9. Geering K. FXYD proteins: New regulators of Na-K-ATPase. Am J Physiol Renal Physiol 290 (2006) F241-F250
10. Nesher M., Shpolansky U., Rosen H., and Lichtstein D. The digitalis-like steroid hormones: New mechanisms of action and biological significance. Life Sci 80 (2007) 2093-2107
11. Kaplan J.H. Biochemistry of Na,K-ATPase. Annu Rev Biochem 71 (2002) 511-535
12. Lingrel J.B., Williams M.T., Vorhees C.V., and Moseley A.E. Na,K-ATPase and the role of alpha isoforms in behavior. J Bioenerg Biomembr 39 (2007) 385-389
13. Urayama O., Shutt H., and Sweadner K.J. Identification of three isozyme proteins of the catalytic subunit of the Na,K-ATPase in rat brain. J Biol Chem 264 (1989) 8271-8280
14. Coppen A., Shaw D.M., Malleson A., and Costain R. Mineral metabolism in mania. Br Med J 1 (1966) 71-75
15. Shaw D.M. Mineral metabolism, mania, and melancholia. Br Med J 2 (1966) 262-267
16. Nurnberger Jr. J., Jimerson D.C., Allen J.R., Simmons S., and Gershon E. Red cell ouabain-sensitive Na+-K+-adenosine triphosphatase: A state marker in affective disorder inversely related to plasma cortisol. Biol Psychiatry 17 (1982) 981-992
17. Naylor G.J., McNamee H.B., and Moody J.P. Changes in erythrocyte sodium and potassium on recovery from a depressive illness. Br J Psychiatry 118 (1971) 219-223
18. Looney S.W., and el-Mallakh R.S. Meta-analysis of erythrocyte Na,K-ATPase activity in bipolar illness. Depress Anxiety 5 (1997) 53-65
19. Goldstein I., Levy T., Galili D., Ovadia H., Yirmiya R., Rosen H., et al. Involvement of Na(+), K(+)-ATPase and endogenous digitalis-like compounds in depressive disorders. Biol Psychiatry 60 (2006) 491-499
20. Lerer E., Kanyas K., Karni O., Ebstein R.P., and Lerer B. Why do young women smoke?. II. Role of traumatic life experience, psychological characteristics and serotonergic genes. Mol Psychiatry 11 (2006) 771-781
21. Chetcuti A., Adams L.J., Mitchell P.B., and Schofield P.R. Microarray gene expression profiling of mouse brain mRNA in a model of lithium treatment. Psychiatr Genet 18 (2008) 64-72
22. Philibert R.A., Cheung D., Welsh N., Damschroder-Williams P., Thiel B., Ginns E.I., et al. Absence of a significant linkage between Na(+),K(+)-ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old-order Amish. Am J Med Genet 105 (2001) 291-294
23. Mujaheed M., Corbex M., Lichtenberg P., Levinson D.F., Deleuze J.F., Mallet J., et al. Evidence for linkage by transmission disequilibrium test analysis of a chromosome 22 microsatellite marker D22S278 and bipolar disorder in a Palestinian Arab population. Am J Med Genet 96 (2000) 836-838
24. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
25. Steen K.V., and Lange C. PBAT: A comprehensive software package for genome-wide association analysis of complex family-based studies. Hum Genomics 2 (2005) 67-69
26. Lange C., DeMeo D., Silverman E.K., Weiss S.T., and Laird N.M. PBAT: Tools for family-based association studies. Am J Hum Genet 74 (2004) 367-369
27. Li T., Ball D., Zhao J., Murray R.M., Liu X., Sham P.C., et al. Family-based linkage disequilibrium mapping using SNP marker haplotypes: Application to a potential locus for schizophrenia at chromosome 22q11. Mol Psychiatry 5 (2000) 77-84
28. Lange C., Silverman E.K., Xu X., Weiss S.T., and Laird N.M. A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics 4 (2003) 195-206
29. Lange C., van Steen K., Andrew T., Lyon H., DeMeo D.L., Raby B., et al. A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol 3 (2004) Article17
30. Sham P.C., and Curtis D. An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann Hum Genet 59 (1995) 323-336
31. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25 (2003) 115-121
32. Schoner W., and Scheiner-Bobis G. Endogenous and exogenous cardiac glycosides: Their roles in hypertension, salt metabolism, and cell growth. Am J Physiol Cell Physiol 293 (2007) C509-C536
33. Bertuccio C.A., Arrizurieta E.E., Ibarra F.R., and Martin R.S. Mechanisms of PKC-dependent Na+ K+ ATPase phosphorylation in the rat kidney with chronic renal failure. Ren Fail 29 (2007) 13-22
34. Weidemann H. Na/K-ATPase, endogenous digitalis like compounds and cancer development-a hypothesis. Front Biosci 10 (2005) 2165-2176
35. Vizi E.S. Na+-K+-activated adenosinetriphosphatase as a trigger in transmitter release. Neuroscience 3 (1978) 367-384
36. Christo P.J., and el-Mallakh R.S. Possible role of endogenous ouabain-like compounds in the pathophysiology of bipolar illness. Med Hypotheses 41 (1993) 378-383
37. Traub N., and Lichtstein D. The mood cycle hypothesis: Possible involvement of steroid hormones in mood regulation by means of Na+, K+-ATPase inhibition. J Basic Clin Physiol Pharmacol 11 (2000) 375-394
38. Vizi E.S., and Oberfrank F. Na+/K(+)-ATPase, its endogenous ligands and neurotransmitter release. Neurochem Int 20 (1992) 11-17
39. Swoboda K.J., Kanavakis E., Xaidara A., Johnson J.E., Leppert M.F., Schlesinger-Massart M.B., et al. Alternating hemiplegia of childhood or familial hemiplegic migraine?. A novel ATP1A2 mutation. Ann Neurol 55 (2004) 884-887
40. de Carvalho Aguiar P., Sweadner K.J., Penniston J.T., Zaremba J., Liu L., Caton M., et al. Mutations in the Na+/K+ -ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism. Neuron 43 (2004) 169-175
41. Fridman A.I., Matveev S.A., Agalakova N.I., Fedorova O.V., Lakatta E.G., and Bagrov A.Y. Marinobufagenin, an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity. J Hypertens 20 (2002) 1189-1194
42. Li R., El-Mallakh R.S., Herman M.M., and Kleinman J.E. Trinucleotide repeat expansion in the beta1 subunit of the sodium pump in manic-depression illness: A negative study. J Affect Disord 60 (2000) 131-136
43. Askland K. Toward a biaxial model of "bipolar" affective disorders: Further exploration of genetic, molecular and cellular substrates. J Affect Disord 94 (2006) 35-66
44. Hashimoto-Gotoh T., Kikuno R., Takahashi M., and Honkawa H. Possible role of the first intron of c-H-ras in gene expression: Anti-cancer elements in oncogenes. Anticancer Res 8 (1988) 851-859
45. Damberg M., Ekblom J., and Oreland L. Chronic pharmacological treatment with certain antidepressants alters the expression and DNA-binding activity of transcription factor AP-2. Life Sci 68 (2000) 669-678
46. Vana A.C., Lucchinetti C.F., Le T.Q., and Armstrong R.C. Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS. Glia 55 (2007) 687-697
47. Rose A.M., Mellett B.J., Valdes Jr. R., Kleinman J.E., Herman M.M., Li R., et al. Alpha 2 isoform of the Na,K-adenosine triphosphatase is reduced in temporal cortex of bipolar individuals. Biol Psychiatry 44 (1998) 892-897
48. Sullivan P.F. Spurious genetic associations. Biol Psychiatry 61 (2007) 1121-1126