Stability of clavulanic acid under variable pH, ionic strength and temperature conditions. A new kinetic approach

Biochemical Engineering Journal

Volumn 45, Issue 2, 2009, Pages 89-93

  Santos, Valéria Carvalho ^a   Pereira, Jorge F Brandão ^b   Haga, Raquel Brandão ^a   Rangel Yagui, Carlota O ^a   Teixeira, José A Couto ^b   Converti, Attilio ^c   Pessoa Jr , Adalberto ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF MINHO   (Portugal)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

Clavulanic acid; Degradation kinetics; Ionic strength; pH; Reversible inactivation; Salts; Stability; Temperature; Thermodynamics

Indexed keywords

ANTI-BACTERIAL ACTIVITIES; CLAVULANIC ACID; DEGRADATION KINETICS; DOWNSTREAM-PROCESSING; EXTRACTIVE FERMENTATIONS; KINETIC AND THERMODYNAMIC PARAMETERS; KINETIC APPROACHES; LACTAMASES; LIQUID LIQUIDS; LONG-TERM STABILITIES; NEW MODELS; POTENT INHIBITORS; PRODUCTION PHASE; REVERSIBLE INACTIVATION; TEMPERATURE CONDITIONS;

ACIDS; BIOCHEMICAL ENGINEERING; CALCIUM CHLORIDE; CARBOXYLIC ACIDS; DEGRADATION; DRUG PRODUCTS; IONIZATION OF LIQUIDS; LIQUIDS; SEWAGE TREATMENT PLANTS; SODIUM CHLORIDE; STABILITY; TEMPERATURE; THERMODYNAMICS;

IONIC STRENGTH;

BUFFER; CALCIUM CHLORIDE; CLAVULANIC ACID; MAGNESIUM CHLORIDE; POLYMER; SODIUM CHLORIDE; SODIUM SULFATE;

ARTICLE; CHEMICAL REACTION KINETICS; COMPLEX FORMATION; DRUG DEGRADATION; DRUG MANUFACTURE; DRUG STABILITY; FERMENTATION; IONIC STRENGTH; LIQUID LIQUID EXTRACTION; PH; PRIORITY JOURNAL; TEMPERATURE; THERMODYNAMICS;

EID: 67349122779     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2009.02.013     Document Type: Article

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