Validation of a GC-FID method for rapid quantification of nicotine in fermented extracts prepared from Nicotiana tabacum fresh leaves and studies of nicotine metabolites

Journal of Pharmaceutical and Biomedical Analysis

Volumn 49, Issue 5, 2009, Pages 1166-1171

  Millet, Agnès ^a   Stintzing, Florian ^b   Merfort, Irmgard ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b WALA HEILMITTEL GMBH   (Germany)

Author keywords

Amine deactivated column; GC FID; GC MS; Nicotiana tabacum; Nicotine metabolites; Nicotine validated quantification

Indexed keywords

2 PYRROLIDINONE; 2,3' BIPYRIDINE; ANATABINE; DRUG METABOLITE; MYOSMINE; NICOTINE; NORNICOTINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DETERMINATION; DRUG ISOLATION; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; PLANT LEAF; PRIORITY JOURNAL; TOBACCO; VALIDATION STUDY;

CALIBRATION; FERMENTATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MODELS, BIOLOGICAL; NICOTINE; PLANT LEAVES; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLUTIONS; TEMPERATURE; TIME FACTORS; TOBACCO;

EID: 67349118398     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.02.024     Document Type: Article

References (25)

1. WALA Drug Directory, 29th ed., WALA Heilmittel GmbH, Bad Boll/Eckwälden, 2007, p.121.
2. Vademecum Anthroposophische Arzneimittel, Der Merkurstab/J. Anthroposophic Med. 61 (Suppl.) (2008) 237-238.
3. Ciolino L.A., Turner J.A., McCauley H.A., Smallwood A.W., and Yi T.Y. J. Chromatogr. A 852 (1999) 451-463
4. Cai J.B., Liu B.Z., Lin P., and Su Q.D. J. Chromatogr. A 1017 (2003) 187-193
5. Wu W., Ashley D.L., and Watson C.H. Anal. Chem. 74 (2002) 4878-4884
6. Man C.N., Gam L.H., Ismail S., Lajis R., and Awang R. J. Chromatogr. B 844 (2006) 322-327
7. Kim I., Darwin W.D., and Huestis M.A. J. Chromatogr. B 814 (2005) 233-240
8. Davis R.A. J. Chromatogr. Sci. 24 (1986) 134-141
9. Zahlsen K., and Nilsen O.G. Pharmacol. Toxicol. 75 (1994) 143-149
10. Saitoh F., Noma M., and Kawashima N. Phytochemistry 24 (1985) 477-480
11. Yang S.S., Smetena I., and Huang C.B. Anal. Bioanal. Chem. 373 (2002) 839-843
12. Homöopathisches Arzneibuch, Spezielle Herstellungsvorschriften, Vorschrift 33c (2003) H5.4 3.
13. Wei X., Sumithran S.P., Deaciuc A.G., Burton H.R., Bush L.P., Dwoskin L.P., and Crooks P.A. Life Sci. 78 (2005) 495-505
14. US Food and Drug Administration Guidance for Industry: Bioanalytical Method Validation 2001, http://www.fda.gov/cder/guidance/4252fnl.pdf (accessed 9/2007).
15. ICH-Q2A International Conference of Harmonization (ICH): Text on Validation of Analytical Procedures 1995, http://www.fda.gov/cder/guidance/ichq2a.pdf (accessed 9/2007).
16. ICH-Q2B International Conference of Harmonization (ICH): Validation of analytical procedures: methodology 1996, http://www.fda.gov/cder/guidance/1320fnl.pdf (accessed 9/2007).
17. Chandran S., and Singh R.S.P. Pharmazie 62 (2007) 4-14
18. Bartholomeusz T., Bhogal R.K., Molinie R., Felpin F.X., Mathe-Allainmat M., Meier A.C., Drager B., Lebreton J., Roscher A., Richard R.J., and Mesnard F. Phytochemistry 66 (2005) 2432-2440
19. Crotti A.E.M., Fonseca T., Hong H., Staunton J., Galembeck S.E., Lopes N.P., and Gates P.J. Int. J. Mass Spectrom. 232 (2004) 271-276
20. Pathak T., Thomas N.F., Akhtar M., and Gani D. Tetrahedron 46 (1990) 1733-1744
21. Wada E., Kisaki T., and Saito K. Arch. Biochem. Biophys. 79 (1959) 124-130
22. Haines P.G., Eisner A., and Woodward C.F. J. Am. Chem. Soc. 67 (1945) 1258-1262
23. Smyth T.J., Ramachandran V.N., McGuigan A., Hopps J., and Smyth W.F. Rapid Commun. Mass. Spectrom. 21 (2007) 557-566
24. Wahlberg I., Karlsson K., Austin D.J., Junker N., Roeraade J., Enzell C.R., and Johnson W.H. Phytochemistry 16 (1977) 1233-1235
25. Zhou J., Bai R., and Zhu Y. Rapid Commun. Mass. Spectrom. 21 (2007) 4086-4092