Chronic exposure to perfluorododecanoic acid disrupts testicular steroidogenesis and the expression of related genes in male rats

Toxicology Letters

Volumn 188, Issue 3, 2009, Pages 192-200

  Shi, Zhimin ^a   Ding, Lina ^a   Zhang, Hongxia ^a   Feng, Yixing ^a   Xu, Muqi ^a   Dai, Jiayin ^a  

^a INSTITUTE OF ZOOLOGY   (China)

Author keywords

Insulin like growth factor I; PFDoA; Steroidogenic acute regulatory protein; Testosterone

Indexed keywords

3ALPHA HYDROXYSTEROID DEHYDROGENASE; AROMATASE; CHOLESTEROL; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); GROWTH HORMONE; INSULIN; INTERLEUKIN 1ALPHA; MESSENGER RNA; PERFLUORODECANOIC ACID; PERFLUORODODECANOIC ACID; SEX HORMONE; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; STEROID 5ALPHA REDUCTASE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPOSURE; GENE EXPRESSION; GROWTH HORMONE BLOOD LEVEL; HISTOPATHOLOGY; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INSULIN BLOOD LEVEL; LIVER; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SEMINAL VESICLE; SEMINIFEROUS TUBULE; STEROIDOGENESIS; TESTIS; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS; VAS DEFERENS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; CHOLESTEROL; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-1ALPHA; LAURIC ACIDS; MALE; ORGAN SIZE; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, IGF TYPE 1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TESTIS; TESTOSTERONE; TIME FACTORS;

ANIMALIA; RATTUS;

EID: 67349117056     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.04.014     Document Type: Article

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