Interleukin-1α stimulates steroidogenic acute regulatory protein expression via p38 MAP kinase in immature rat Leydig cells

Journal of Molecular Endocrinology

Volumn 30, Issue 1, 2003, Pages 59-67

  Svechnikov, K ^a,c   Stocco, D M ^b   Soder O ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^c INSTITUTE OF CYTOLOGY AND GENETICS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 NITROPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; INTERLEUKIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; STEROIDOGENIC ACUTE REGULATORY PROTEIN; SYNAPTOPHYSIN; TESTOSTERONE; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; INTERLEUKIN 1; PHOSPHOPROTEIN; PYRIDINE DERIVATIVE;

ANDROGEN SYNTHESIS; ANIMAL CELL; ANIMAL EXPERIMENT; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME INHIBITION; HORMONAL REGULATION; IN VITRO STUDY; LEYDIG CELL; MALE; NONHUMAN; PARACRINE SIGNALING; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STEROIDOGENESIS; TESTIS; ANIMAL; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ANIMALS; ENZYME INHIBITORS; IMIDAZOLES; INTERLEUKIN-1; LEYDIG CELLS; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0141500061     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0300059     Document Type: Review

References (39)

1. Artemenko IP, Zhao, D, Hales DB, Hales KH & Jefcoate CR 2001 Mitochondrial processing of newly synthesized steroidogenic acute regulatory protein (StAR), but not total StAR, mediates cholesterol transfer to cytochrome P450 side chain cleavage enzyme in adrenal cells. Journal of Biological Chemistry 276 46583-46596.
2. Baldassare JJ, Bi Y & Bellone CJ 1999 The role of p38 mitogen-activated protein kinase in IL-1 beta transcription. Journal of Immunology 162 5367-5377.
3. Bankers-Fulbright JL, Kalli KR & McKean DJ 1996 Interleukin-1 signal transduction. Life Sciences 59 61-83.
4. Buzek SW & Sanborn BM 1988 Increase in testicular androgen receptor during sexual maturation in the rat. Biology of Reproduction 39 39-49.
5. Calkins JH, Sigel MM, Nankin HR & Lin T 1988 Interleukin-1 inhibits Leydig cell steroidogenesis in primary culture. Endocrinology 123 1605-1610.
6. Christenson LK & Strauss JF II 2000 Steroidogenic acute regulatory protein (StAR) and the intramitochondrial translocation of cholesterol. Biochimica et Biophysica Acta 1529 175-187.
7. Clark BJ, Wells J, King SR & Stucco DM 1994 The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in XM-10 mouse tumor Leydig cells. Characterization of the steroidogenic acute regulating protein (StAR). Journal of Biological Chemistry 269 28314-28322.
8. Davies SP, Reddy H, Caivano, M & Cohen P 2000 Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochemical Journal 351 95-105.
9. Dinarello CA 1991 Interleukin-1 and interleukin-1 antagonism. Blood 77 1627-1652.
10. Ge R-S, Shan L-X & Hardy MP 1996 Pubertal development of Leydig cells. In The Leydig Cell, pp 159-174. Eds AH Payne, MP Hardy & LD Russell. Vienna: Cache River Press.
11. Gustafsson K, Söder O, Pöllänen P & Ritzén EM 1988 Isolation and partial characterization of an interleukin-1-like factor from rat testis interstitial fluid. Journal of Reproductive Immunology 14 139-150.
12. Gustafsson K, Sultana T, Zetterström CK, Setchel BP, Siddiqui A, Günther W & Söder O 2002 Production and secretion of interleukin-1α proteins by rat testis. Biochemical and Biophysical Research Communications 297 492-497.
13. Gyles SL, Burns CJ, Whitehouse BJ, Sugden D, Marsh PJ, Persaud SJ & Jones PM 2001 ERKs regulate cyclic AMP-induced steroid synthesis through transcription of the steroidogenic acute regulatory (StAR) gene. Journal of Biological Chemistry 276 34888-34895.
14. Isshiki H, Akira S, Tanabe O, Nakajama T, Shimamoto T, Hirano T & Kishimato T 1990 Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene. Molecular and Cellular Biology 10 2757-2764.
15. Jonsson CK, Zetterström RH, Holst M, Parvinen M & Söder O 1999 Constitutive expression of interleukin-1α messenger ribonucleic acid in rat Sertoli cells is dependent upon interaction with germ cells. Endocrinology 140 3755-3761.
16. Jonsson C, Setchell B, Martinelle N, Svechnikov K & Söder O 2001 Endotoxin-induced interleukin-1 expression in testicular macrophages is accompanied by down-regulation of the constitutive expression in Sertoli cells. Cytokine 14 283-288.
17. Khan SA, Söder O, Syed V, Gustafsson K, Lindh M & Ritzén M 1987 The rat testis produces large amounts of an interleukin-1-like factor. International Journal of Andrology 10 495-503.
18. Manna PR, Dyson MT, Eubank DW, Clark BJ, Lalli E, Sassone-Corsi P, Zeleznik AJ & Stocco DM 2002 Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family. Molecular Endocrinology 16 184-199.
19. Mendis-Handagama SM & Ariyaratne HB 2001 Differentiation of the adult Leydig cell population in the postnatal testis. Biology of Reproduction 65 660-671.
20. Metz R & Ziff E 1991 cAMP stimulates the C/EBP-related transcription factor rNF IL-6 to translocate to the nucleus and induce c-fos transcription. Genes and Development 5 1754-1766.
21. Misro MM, Ganguly A & Das RP 1993 Is testosterone essential for maintenance of normal morphology in immature rat Leydig cells? International Journal of Andrology 16 221-226.
22. Moore C & Moger WH 1991 Interleukin-1α-induced changes in androgen and cyclic adenosine 3′,5′-monophosphate release in adult rat Leydig cells in culture. Journal of Endocrinology 129 381-390.
23. Nalbant D, Williams SC, Stocco DM & Khan S 1998 Luteinizing hormone-dependent gene regulation in Leydig cells may be mediated by CCAAT/enhancer binding protein-beta. Endocrinology 139 272-279.
24. Neumann D, Kollewe C, Martin MU & Boraschi D 2000 The membrane form of the type II IL-1 receptor account for inhibitory function. Journal of Immunology 165 3350-3357.
25. Parvinen M, Söder O, Mali P, Fröysa B & Ritzen EM 1991 In vitro stimulation of stage-specific deoxyribonucleic acid synthesis in rat seminiferous tubule segments by interleukin-1α. Endocrinology 129 1614-1620.
26. Payne AH, Downing JR & Wong KL 1980 Luteinizing hormone receptors and testosterone synthesis in two distinct populations of Leydig cells. Endocrinology 106 1424-1429.
27. Pearson G, Robinson F, Gibson TB, Xu B-E, Karandikar M, Berman K & Cobb MH 2001 Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocrine Reviews 22 153-183.
28. MAPK). Journal of Biological Chemistry 273 29661-29671.
29. Pöllänen P, Söder O & Parvinen M 1989 Interleukin-1α stimulation of spermatogonial proliferation in vivo. Reproduction, Fertility, and Development 1 85-87.
30. Reinhart AJ, Williams SC, Clark BJ & Stocco DM 1999 SF-1 (steroidogenic factor-1) and C/EBP beta (CCAAT/enhancer binding protein-beta) cooperate to regulate the murine StAR (steroidogenic acute regulatory) promoter. Molecular Endocrinology 13 729-741.
31. Silverman E, Eimerl S & Orly J 1999 CCAAT enhancer-binding protein beta and GATA-4 binding regions within the promoter of the steroidogenic acute regulatory protein (StAR) gene are required for transcription in rat ovarian cells. Journal of Biological Chemistry 274 17987-17996.
32. Sirois J & Richards JS 1993 Transcriptional regulation of the rat prostaglandin endoperoxidase syntase 2 gene in granulosa cells. Evidence for the role of a cis-acting C/EBP beta promoter element. Journal of Biological Chemistry 268 21931-21938.
33. Stocco DM 2001 StAR protein and the regulation of steroid hormone biosynthesis. Annual Review of Physiology 63 193-213.
34. Sultana T, Svechnikov K, Weber G & Söder O 2000 Molecular cloning and expression of a functionally different alternative splice variant of prointerleukin-1α from the rat testis. Endocrinology 141 4413-4418.
35. Svechnikov KV, Sultana T & Söder O 2001 Age-dependent stimulation of Leydig cell steroidogenesis by interleukin-1 isoforms. Molecular and Cellular Endocrinology 182 193-201.
36. Tovey MG, Content J, Gresser I, Gugenheim J, Blanchard B, Guymarho J, Poupart P, Gigou M, Shaw A & Fiers W 1988 Genes for IFN-β-2 (IL-6), tumor necrosis factor, and IL-1 are expressed at high levels in the organs of normal individuals. Journal of Immunology 141 3106-3110.
37. Verhoeven G, Cailleau J, Van Damme J & Billiau A 1988 Interleukin-1 stimulates steroidogenesis in cultured rat Leydig cells. Molecular and Cellular Endocrinology 57 51-60.
38. Wahab-Wahlgren A, Holst M, Ayele D, Sultana T, Parvinen M, Gustafsson K, Granholm T & Söder O 2000 Constitutive production of interleukin-1α mRNA and protein in the developing rat testis. International Journal of Andrology 23 360-365.
39. Wang XJ, Walsh LP, Reinhart AJ & Stocco DM 2000 The role of arachidonic acid in steroidogenesis and steroidogenic acute regulatory (StAR) gene and protein expression. Journal of Biological Chemistry 275 20204-20209.