Binding specificity of the l-arginine transport systems in mouse macrophages and human cells overexpressing the cationic amino acid transporter hCAT-1

Amino Acids

Volumn 36, Issue 3, 2009, Pages 483-492

  Eros, Dániel ^b   Orfi, László ^b   Csuka, Ildikó ^a   Kéri, György ^a,b   Hrabák, András ^a  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b Vichem Chemie Ltd   (Hungary)

Author keywords

Arginine; Binding specificity; Cationic amino acid transporter; Inhibition; Quantitative structure activity relationship

Indexed keywords

ALIPHATIC CARBOXYLIC ACID; AMINO ACID TRANSPORTER; ARGININE; CARBOXYL GROUP; GUANIDINE DERIVATIVE; LYSINE;

ACIDITY; ANIMAL CELL; ARTICLE; CELL LINE; COMPETITIVE INHIBITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROPHOBICITY; KINETICS; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TRANSPORT; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANIMALS; ARGININE; BINDING SITES; BIOLOGICAL TRANSPORT; CATIONIC AMINO ACID TRANSPORTER 1; CELL LINE, TUMOR; HUMANS; KINETICS; MACROPHAGES, PERITONEAL; MICE;

EID: 67349115350     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-008-0106-x     Document Type: Article

References (44)

1. 3DNET4 W (2002) Vichem Ltd., Budapest, Hungary
2. ACD/Labs (2002) Ver. 6.0, Advanced Chemistry Development Inc. Toronto
3. AR Baydoun RG Bogle JD Pearson GE Mann 1994 Discrimination between citrulline and arginine transport in activated murine macrophages: inefficient synthesis of NO from recycling of citrulline to arginine Br J Pharmacol 112 487 492 (Pubitemid 24172889)
4. AG Baydoun GE Mann 1994 Selective targeting of nitric oxide synthase inhibitors to system y + in activated macrophages Biochem Biophys Res Commun 200 726 731 (Pubitemid 24146023)
5. RG Bogle AR Baydoun JD Pearson S Moncada GE Mann 1992 l-arginine transport is increased in macrophages generating nitric oxide Biochem J 284 15 18
6. MM Bradford 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 248 254
7. EI Closs 1996 CATs, a family of three distinct mammalian cationic amino acid transporter Amino Acids 11 193 208 (Pubitemid 26326773)
8. EI Closs FZ Basha A Habermeier U Förstermann 1997 Interference of L-arginine analogues with L-arginine transport mediated by the y + carrier hCAT-2B Nitric Oxide 1 65 73 (Pubitemid 28078129)
9. EI Closs JS Scheld M Sharafi U Forstermann 2000 Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters Mol Pharmacol 57 68 74 (Pubitemid 30033261)
10. EI Closs A Simon N Vekony A Rottman 2004 Plasma membrane transporters for arginine J Nutr 134 2752S 2759S (Pubitemid 39315216)
11. EI Closs JP Boissel A Habermaier A Rotmann 2006 Structure and function of cationic amino acid transporters (CATs) J Membrane Biol 213 67 77 (Pubitemid 46626126)
12. GA Currie 1978 Activated macrophages kill tumour cells by releasing arginase Nature 273 758 759 (Pubitemid 8357089)
13. D Eros I Kövesdi L Orfi K Takács-Novák Gy Acsády Gy Kéri 2002 Reliability of logP predictions based on calculated molecular descriptors: a critical review Curr Med Chem 9 1819 1829
14. M Flodstrom MC Chen A Smismans F Schuit DG Pipeleers DL Eizirik 1999 Interleukin 1beta increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic beta cells Cytokine 11 400 407 (Pubitemid 29259634)
15. C Hansch JP Bjorkroth A Leo 1987 Hydrophobicity and central nervous system agents: on the principle of minimal hydrophobicity in drug design J Pharm Sci 76 663 687 (Pubitemid 18026974)
16. C Hey JL Boucher S Vadon-Le Goff G Ketterer I Wessler K Racké 1997 Inhibition of arginase in rat and rabbit alveolar macrophages by Nω-hydroxy-D, l-indospicine, effects on d-arginine utilization by nitric oxide synthase Br J Pharmacol 121 395 400 (Pubitemid 27226290)
17. H Hosokawa T Sawamura S Kobayashi H Ninomiya S Miwa T Masaki 1997 Cloning and characterization of a brain-specific cationic amino acid transporter J Biol Chem 272 8717 8722 (Pubitemid 27147840)
18. A Hrabák T Bajor Á Temesi 1994 Comparison of substrate and inhibitor specificity of arginase and nitric oxide (NO) synthase for arginine analogues and related compounds in murine and rat macrophages Biochem Biophys Res Commun 198 206 212 (Pubitemid 24172740)
19. A Hrabák M Idei Á Temesi 1994 Arginine supply for nitric oxide synthesis and arginase is mainly exogeneous in elicited murine and rat macrophages Life Sci 55 797 805 (Pubitemid 24250042)
20. A Hrabák T Bajor Á Temesi 1996 Computer-aided comparison of the inhibition of arginase and nitric oxide synthase in macrophages by amino acids not related to arginine Comp Biochem Physiol 113B 375 381 (Pubitemid 26139602)
21. Y Inoue BP Bode DJ Beck AP Li KI Bland WW Souba 1993 Arginine transport in human liver. Characterization and effects of nitric oxide synthase inhibitors Ann Surg 218 350 362 (Pubitemid 23270390)
22. K Ito M Groudine 1997 A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain J Biol Chem 272 26780 26786 (Pubitemid 27458907)
23. DK Kakuda MJ Sweet CL Mac Leod DA Hume D Markovich 1999 CAT2-mediated l-arginine transport and nitric oxide production in activated macrophages Biochem J 340 549 553 (Pubitemid 29286578)
24. Labute P (1998) MOE LogP(Octanol/Water) Model. unpublished. Source code in MOE (MOE/lib/svl/quasar.svl/q-logp.svl)
25. Lehninger AL, Nelson DL, Cox MM (1993) Principles of biochemistry, 2nd edn edn. Worth Publisher, New York, p 914
26. CL MacLeod DK Kakuda 1996 Regulation of CAT: cationic amino acid transporter gene expression Amino Acids 11 171 191 (Pubitemid 26326772)
27. CK Manner B Nicholson CL MacLeod 2003 CAT2 arginine transporter deficiency significantly reduces iNOS-mediated NO production in astrocytes J Neurochem 85 476 482 (Pubitemid 36438343)
28. MA Marletta 1994 Approaches toward selective inhibition of nitric oxide synthase J Med Chem 37 1899 1907 (Pubitemid 24233601)
29. L Martin M Comalada L Marti EI Closs CL MacLeod R Martin del Rio A Zorzano M Modolell A Celada M Palacin J Bertran 2006 Granulocyte-macrophage colony-stimulating factor increases l-arginine transport through the induction of CAT2 in bone marrow-derived macrophages Am J Physiol Cell Physiol 290C 1364 1372
30. MOE 2006.08 Copyright (c) 1997-2006 Chemical Computing Group Inc
31. S Moncada RMJ Palmer EA Higgs 1991 Nitric oxide: physiology, pathophysiology, and pharmacology Pharmacol Rev 43 109 142
32. B Nicholson CK Manner J Kleeman CL MacLeod 2001 Sustained nitric oxide production in macrophages requires the arginine transporter CAT2 J Biol Chem 276 15881 15885 (Pubitemid 37391619)
33. A Rotmann D Strand U Martiné EI Closs 2004 Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1 J Biol Chem 279 54185 54192
34. A Rotmann N Vékony D Gassner G Niegisch D Strand U Martiné EI Closs 2006 Activation of classical protein kinase C reduces the expression of the human cationic amino acid transporter hCAT-3 in the plasma membrane Biochem J 395 117 123
35. A Rotmann A Simon U Martiné A Habermeier EI Closs 2007 Activation of classical protein kinase C decreases transport via systems y + and y + L Am J Physiol Cell Physiol 292 2259 2268 (Pubitemid 47080516)
36. H Sato M Fujiwara S Bannai 1992 Effect of lipopolysaccharide on transport and metabolism of arginine in mouse peritoneal macrophages J Leukoc Biol 52 161 164
37. K Schmidt P Klatt B Mayer 1994 Uptake of nitric oxide synthase inhibitors by macrophage RAW 264.7 cells Biochem J 301 313 316 (Pubitemid 24231927)
38. WS Simmons EI Closs JM Cunningham TW Smith RA Kelly 1996 Cytokines and insulin induce cationic amino acid transporter (CAT) expression in cardiac myocytes J Biol Chem 271 11694 11702
39. MT Talaue V Venketaraman MH Hazbon M Peteroy-Kelly A Seth R Colangeli D Alland ND Connell 2006 Arginine homeostasis in J774.1 macrophages in the context of Mycobacterium bovis BCG infection J Bacteriol 188 4830 4840 (Pubitemid 43956081)
40. N Vekony S Wolf JP Boissel K Gnauert EI Closs 2001 Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues Biochemistry 40 12387 12394 (Pubitemid 32959761)
41. MF White 1985 The transport of cationic amino acids across the plasma membrane of mammalian cells Biochim Biophys Acta 822 355 374 (Pubitemid 16196324)
42. SA Wildman GM Crippen 1999 Prediction of physiochemical parameters by atomic contributions J Chem Inf Comput Sci 39 868 873
43. S Wolf A Janzen N Vékony U Martiné D Strand EI Closs 2002 Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity Biochem J 364 767 775 (Pubitemid 34680853)
44. A Yeramian L Martin L Arpa J Bertran C Soler C McLeod M Modolell M Palacin J Lloberas A Celada 2006 Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation Eur J Immunol 36 1516 1526 (Pubitemid 43942140)