Optimization of automated large-scale production of [18F]fluoroethylcholine for PET prostate cancer imaging

Nuclear Medicine and Biology

Volumn 36, Issue 5, 2009, Pages 569-574

  Pascali, Giancarlo ^a   D'Antonio, Luca ^b   Bovone, Paola ^b   Gerundini, Paolo ^b   August, Thorsten ^c  

^a UNIVERSITY OF PISA   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^c Eckert and Ziegler EURO PET Berlin GmbH   (Germany)

Author keywords

FEC; Fluoroethylcholine; Modular Lab; PET; Prostate cancer; Radiosynthesis

Indexed keywords

FLUORINE 18; FLUOROETHYLCHOLINE F 18; UNCLASSIFIED DRUG;

ARTICLE; AUTOMATION; DRUG MANUFACTURE; DRUG STRUCTURE; POSITRON EMISSION TOMOGRAPHY; PROCESS OPTIMIZATION; PROSTATE CANCER; QUALITY CONTROL; RADIOACTIVITY; SOLID PHASE EXTRACTION;

AUTOMATION; CHOLINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MALE; POSITRON-EMISSION TOMOGRAPHY; PROSTATIC NEOPLASMS; QUALITY CONTROL; RADIOACTIVITY;

EID: 67349114229     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2009.01.004     Document Type: Article

References (24)

1. 18F-fluoroethylcholine for cancer imaging with PET: synthesis, biochemistry, and prostate cancer imaging. J Nucl Med 43 (2002) 187-199
2. 18F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer. J Urol 168 (2002) 273-280
3. Negendank W. Studies of human tumors by MRS: a review. NMR Biomed 5 (1992) 303-324
4. De Certaines J.D., Larsen V.A., Podo F., et al. In vivo 31P MRS of experimental tumors: a review. NMR Biomed 6 (1993) 345-365
5. Hara T., Kosaka N., Shinoura N., and Kondo T. PET imaging of brain tumor with [methyl-11C]choline. J Nucl Med 38 (1997) 842-847
6. 11C-choline PET. J Nucl Med 41 (2000) 1507-1513
7. Kobori O., Kirihara Y., Kosaka N., and Hara T. Positron emission tomography of esophageal carcinoma using 11C-choline and 18F-fluorodeoxyglucose. Cancer 86 (1999) 1638-1648
8. Hara T., Kosaka N., Kondo T., Kishi H., and Kobori O. Imaging of brain tumor, lung cancer, esophagus cancer, colon cancer, prostate cancer, and bladder cancer with [C-11]choline [abstract]. J Nucl Med 38 Suppl (1997) 250P
9. Hara T., Kosaka N., and Kishi H. PET imaging of prostate cancer using carbon-11-choline. J Nucl Med 39 (1998) 990-995
10. Deves R., and Krupka R.M. The binding and translocation steps in transport as related to substrate structure: a study of the choline carrier of erythrocytes. Biochim Biophys Acta 557 (1979) 469-485
11. Yu H.K., Park J.H., and Yang S.D. Synthesis of [18F]fluorocholine analogues as a potential imaging agent for PET studies. Bull Korean Chem Soc 25 4 (2004) 506-509
12. DeGrado T.R., Coleman R.E., Wang S., et al. Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer. Cancer Res 61 (2000) 110-117
13. DeGrado T.R., Baldwin S.W., Wang S., et al. Synthesis and evaluation of 18F-labeled choline analogs as oncologic PET tracers. J Nucl Med 42 (2001) 1805-1814
14. DeGrado T.R., Reiman R.E., Price D.T., et al. Pharmacokinetics and radiation dosimetry of 18F-fluorocholine. J Nucl Med 43 (2002) 92-96
15. web source:. http://clinicaltrials.gov/show/NCT00520546
16. web source:. http://clinicaltrials.gov/show/NCT00670527
17. 18F]fluoroethylcholine as a radiotracer for cancer imaging. Bioorg Med Chem 15 (2007) 3171-3175
18. European Pharmacopeia 6.0, vol.1, chap.5.4, 604-610.
19. Kwee S.A., DeGrado T.R., Talbot J.N., Gutman F., and Coel M.N. Cancer imaging with fluorine-18-labeled choline derivates. Semin Nucl Med 37 (2007) 420-428
20. Li Z., and Vance D.E. Phosphatidylcholine and choline homeostasis. J Lipid Res 49 (2008) 1187-1194
21. Rosen M.K., Jones R.M., Yano Y., and Budinger T.F. Carbon-11 choline: synthesis, purification, and brain uptake inhibition by 2-dimethylaminoethanol. J Nucl Med 26 (1985) 1424-1428
22. 18F]dOC). Nuc Med Biol 31 (2004) 851-858
23. 18F]fluoroethylcholine uptake in prostate cancer cells. J Nucl Med 47 Suppl 1 (2006) 425P
24. http://www.eurotope.de/products/modular_lab_syntheses/.