Rapid oxidation of ring methyl groups is the primary mechanism of biotransformation of gemfibrozil by the fungus Cunninghamella elegans

Archives of Microbiology

Volumn 191, Issue 6, 2009, Pages 509-517

  Kang, Su Il ^a   Kang, Seo Young ^a   Kanaly, Robert A ^b   Lee, Eunjung ^c   Lim, Yoongho ^c   Hur, Hor Gil ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c Konkuk University   (South Korea)

Author keywords

Cunninghamella elegans; Fungal metabolism; Gemfibrozil; Hydroxylation; Hypolipidemic

Indexed keywords

2',5' DIHYDROXYMETHYLGEMFIBROZIL; 3' HYDROXYMETHYLGEMFIBROZIL; 5' HYDROXYMETHYLGEMFIBROZIL; DRUG METABOLITE; GEMFIBROZIL; UNCLASSIFIED DRUG;

ARTICLE; BIODEGRADATION; CONTROLLED STUDY; CUNNINGHAMELLA ELEGANS; DRUG METABOLISM; DRUG TRANSFORMATION; FUNGAL METABOLISM; FUNGUS CULTURE; NONHUMAN; OXIDATION; PRIORITY JOURNAL;

BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CUNNINGHAMELLA; GEMFIBROZIL; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; TANDEM MASS SPECTROMETRY;

ANIMALIA; CAENORHABDITIS ELEGANS; CUNNINGHAMELLA ELEGANS; FUNGI;

EID: 67349109892     PISSN: 03028933     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00203-009-0480-0     Document Type: Article

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