Human embryonic stem cell-derived neuronal cells form spontaneously active neuronal networks in vitro

Experimental Neurology

Volumn 218, Issue 1, 2009, Pages 109-116

  Heikkilä, Teemu J ^a   Ylä Outinen, Laura ^a   Tanskanen, Jarno M A ^a   Lappalainen, Riikka S ^a   Skottman, Heli ^a   Suuronen, Riitta ^a,b   Mikkonen, Jarno E ^a   Hyttinen, Jari A K ^a   Narkilahti, Susanna ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

hESC derived neuronal networks; Human embryonic stem cell derived neurons; MEA; Microelectrode array; Neuronal differentiation; Neuronal network; Polyethyleneimine; Spike train; Stem cells; Synchronous bursting

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR; BETA TUBULIN; BICUCULLINE METHIODIDE; GLUTAMATE RECEPTOR; MICROTUBULE ASSOCIATED PROTEIN 2; SODIUM CHANNEL; TETRODOTOXIN;

ARTICLE; CELL COMMUNICATION; CELL VIABILITY; CONTROLLED STUDY; DRUG RESEARCH; EMBRYO; EMBRYONIC STEM CELL; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MICROELECTRODE; NERVE CELL; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NERVE CELL EXCITABILITY; NERVE CELL NETWORK; PRIORITY JOURNAL; REGENERATIVE MEDICINE; SYNAPSE;

ACTION POTENTIALS; BIOSENSING TECHNIQUES; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; ELECTRIC STIMULATION; EMBRYONIC STEM CELLS; EXCITATORY AMINO ACID AGENTS; GABA AGENTS; HUMANS; MICROELECTRODES; NERVE NET; NEURONS; SODIUM CHANNEL BLOCKERS; TETRODOTOXIN; TIME FACTORS;

EID: 67349094283     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2009.04.011     Document Type: Article

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