Anti-parasitic activity and cytotoxicity of selected medicinal plants from Kenya

Journal of Ethnopharmacology

Volumn 123, Issue 3, 2009, Pages 504-509

  Kigondu, Elizabeth V M ^a,b   Rukunga, Geoffrey M ^b   Keriko, Joseph M ^c   Tonui, Willy K ^b   Gathirwa, Jeremiah W ^b   Kirira, Peter G ^b   Irungu, Beatrice ^b   Ingonga, Johnstone M ^b   Ndiege, Isaiah O ^d  

^a Institute of Tropical Medicine and Infectious Diseases (ITROMID)   (Kenya)

^b KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^c JOMO KENYATTA UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Kenya)

^d KENYATTA UNIVERSITY   (Kenya)

Author keywords

Anti leishmanial; Anti plasmodial; Cytotoxicity; In vitro; Plant extracts

Indexed keywords

ACACIA TORTILIS EXTRACT; ALBIZIA CORIARIA EXTRACT; ALOE MYERIENSIS EXTRACT; ANTILEISHMANIAL AGENT; ANTIMALARIAL AGENT; ANTIPARASITIC AGENT; ASPARAGUS RACEMOSUS EXTRACT; CHLOROQUINE; DELONIX ELATA EXTRACT; MAYTENUS PUTTERLICKOIDES EXTRACT; METHANOL; PLANT EXTRACT; STIBOGLUCONATE SODIUM; SUREGADA ZANZIBARIENSIS EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; ASPERGILLUS; ASPERGILLUS RACEMOSUS; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; EMBRYO; EMBRYO CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; KENYA; LEISHMANIA MAJOR; LUNG FIBROBLAST; MEDICINAL PLANT; NONHUMAN; PERITONEUM MACROPHAGE; PLANT LEAF; PLANT ROOT; PLANT STEM; PLASMODIUM FALCIPARUM;

ANGIOSPERMS; ANIMALS; ANTIMALARIALS; CELL LINE; CELL LINE, TUMOR; FIBROBLASTS; HUMANS; LEISHMANIA MAJOR; MACROPHAGES; PLANT EXTRACTS; PLANTS, MEDICINAL; TRYPANOCIDAL AGENTS;

ACACIA TORTILIS; ALBIZIA; ALOE NYERIENSIS; ASPARAGUS RACEMOSUS; ASPERGILLUS; CORIARIA; LEISHMANIA MAJOR; MAYTENUS PUTTERLICKOIDES; PLASMODIUM FALCIPARUM; SUREGADA;

EID: 67349085086     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.02.008     Document Type: Article

References (24)

1. Azas N., Laurencin N., Delmas F., Di Giorgi C., Gasquet M., Laget M., and Timon-David P. Synergistic in vitro anti-malarial activity of plant extracts used as traditional herbal remedies in Mali. Parasitology Research 88 (2004) 165-171
2. Berman J.D., and Lee L.S. Activity of anti-leishmanial agents against amastigotes in human monocytes derived macrophages and in mouse peritoneal macrophages. Journal of Parasitology 70 (1984) 220-225
3. Delorenzi J.C., Attias M., Gattass C.R., Andrade M., Rezende C., Da Cunha Pinto A., Henriques A.T., Bou-Habib D.C., and Saraiva E.M. Anti-leishmanial activity of an indole alkaloid from Peschiera australis. Antimicrobial Agents Chemotherapy 45 (2001) 1349-1354
4. Desjardins R.E., Canfield C.J., Haynes J.D., and Chulay J.D. Quantitative assessment of anti-malarial activity in vitro by a semi-automated micro-dilution technique. Antimicrobial Agents Chemotherapy 16 (1979) 710-718
5. Dianne J., Jeanne M., Margarette S., Oren S., Aggrey J., Piet A., Altaf A., Bernard L., and Feiko O. Treatment history and treatment dose are important determinants of sulfadoxine-pyrimethamine efficacy in children with uncomplicated malaria in western Kenya. Journal of Infectious Diseases 187 (2003) 467-468
6. Dorin D., Le Roch K., Sallicandro P., Alano P., Parzy D., Poullet P., Meijer L., and Doerig C. Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum. Biochemical properties and possible involvement in MAPK regulation. European Journal of Biochemistry 268 (2001) 2600-2608
7. Eluenze E.I., Croft C.L., and Warhust D.C. Activity of pyronaridine and mepacrine against twelve strains of Plasmodium falciparum in vitro. Journal of Antimicrobial Chemotherapy 37 (1996) 511-518
8. Evans D., Godfrey D., Lanham S., Lanotte G., Modabber F., and Schnur I. In: Evans D. (Ed). Handbook on Isolation Characterization and Cryopreservation of Leishmania (1989), UNDP/World Bank/WHO/TDR, Geneva
9. Fendall N.R. The spread of kala-azar in Kenya. East African Medical Journal 38 (1961) 417-419
10. Gachathi F.N. Kikuyu Botanical Dictionary of Plant Names and Uses (1989), AMREF Printing Department, Nairobi
11. Holzmuller P., Sereno D., Cavalevra M., Mangot I., Daulouede S., Vincendeau P., and Lemesre J.L. Nitric oxide-mediated proteasome-dependent oligonucleosomal DNA fragmentation in Leishmania amazonensis amastigotes. Infection and Immunity 70 (2002) 3727-3735
12. Kayser O., Kiderlen A.F., and Croft S.L. Natural products as potential anti-parasitic drugs. Parasitology Research 87 Suppl. 2 (2003) S55-S62
13. Kokwaro J.O. Medicinal Plants of East Africa (1993), Kenya Literature Bureau, Nairobi
14. Mello H., Echevarria A., Bernardino A.M., Canto-Cavalheiro M., and Leon L.L. Anti-leishmanial pyrazolopyridine derivatives: synthesis and structure-activity relationship analysis. Journal of Medicinal Chemistry 47 (2004) 5427-5432
15. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods 65 (1983) 55-63
16. Muregi F.W., Chhabra S.C., Njagi E.N.M., Lang'at-Thoruwa C.C., Njue W.M., Orago A.S.S., and Ndiege I.O. In vitro anti-plasmodial activity of some plants used in Kisii, Kenya, against malaria and their chloroquine potentiation effects. Journal of Ethnopharmacology 84 (2003) 235-239
17. Omulokoli E., Khan B., and Chhabra S.C. Anti-plasmodial activity of four Kenyan medicinal plants. Journal of Ethnopharmacology 2 (1997) 133-137
18. Schwartlander B. Global burden of disease. Lancet 350 (1997) 141-142
19. Singh S., and Sivakumar R. Challenges and new discoveries in the treatment of leishmaniasis. Journal of Infection and Chemotherapy 10 (2004) 307-315
20. Sixsmith D.G., Watkins W.M., Chuly J.D., and Spencer H.C. In vitro anti-malarial activity of tetrahydrofolate dehydrogenase inhibitors. American Journal of Tropical Medicine Hygiene 33 (1984) 772-776
21. Tasdemir D., Guner N.D., Perozzo R., Brun R., Donmez A.A., Calis I., and Ruedi P. Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots. Phytochemistry 66 (2005) 355-362
22. Trager W., and Jensen J.B. Human malaria parasites in continuous culture. Science 193 (1976) 673-675
23. WHO, 1996. Investing in Health Research and Development. WHO Document TDR/Gen/96.1. Report of the Ad Hoc Committee of Health Research Relating to Future Intervention Options. WHO, Geneva.
24. Zirihi G.N., Mambu L., Guede-Guina F., Bodo B., and Grellier P. In vitro anti-plasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. Journal of Ethnopharmacology 98 (2005) 281-285