Effect of hemin on severe acute pancreatitis-associated lung injury in rats and its mechanism

Journal of Central South University (Medical Sciences)

Volumn 34, Issue 3, 2009, Pages 242-246

  Liu, Zhiyong ^a   Ai, Yuhang ^a   Zhang, Lina ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Hemin; ho 1; Nf b; Severe acute pancreatitis

Indexed keywords

CYTOKINE; HEME OXYGENASE; HEMIN; HMOX1 PROTEIN, RAT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA;

ACUTE HEMORRHAGIC PANCREATITIS; ACUTE LUNG INJURY; ANIMAL; ARTICLE; FEMALE; GENETICS; MALE; METABOLISM; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

ACUTE LUNG INJURY; ANIMALS; CYTOKINES; FEMALE; HEME OXYGENASE (DECYCLIZING); HEMIN; MALE; NF-KAPPA B; PANCREATITIS, ACUTE NECROTIZING; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 67249108292     PISSN: 16727347     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Browne G W, Pitchumoni C S. Pathophysiology of pulmonary complications of acute pancreatitis [J]. World J Gastroenterol, 2006,12(44) :7087-7096.
2. Otterbein L E, Choi A M. Heme oxygenase : colors of defense against cellular stress [J]. Am J Physiol Lung Cell Mol Physiol,2000,279(6) L1029-L1037.
3. Tsuehihashi S, Fondevila C, Kupiec - Weglinski J W, et al. Heme oxygenase system in ischemia and reperfusion injury [J]. Ann Transplant,2004. 9 (1) 84-87.
4. Hartwig W, Werner J, Jimenez R E, et al. Trypsin and acti-vation of circulating trypsinogen contribute to pancreatitis - associated lung injury [J]. AmJ Physiol, 1999, 277 (5 Pt 1) 1008-1016.
5. Renner I G, Savage W T, Pantoja J L, et al. Death due to acute pancreatitis : a retrospective analysis of 405 autopsy cases [J]. Dig Dis Sci.1985,30 (10) : 1005-1018.
6. Morse D, Choi A M. Heme oxygenase -1 : The " emerging molecule" has arrived [J]. Am J Respir Cell Mol Biol, 2002,27(1) :8-16.
7. Wang X H, Wang K, Zhang F, et al. Alleviating ischemia - reperfusion injury in aged rat liver by induction of heme oxygenase-! [J]. Transplant Proc, 2004, 36 (10) 2917- 2923.
8. Jaffray C, Yang J, Carter G, et al. Pancreatic elastase activates pulmonary nuclear factor kappa B and inhibitory kappa B, mimicking pancreatitis - associated adult respiratory distress syndrome[J]. Surgery, 2000, 128 (2) : 225-231.
9. Gray K D, Simovic M 0, Blackwell T S, et al. Activation of nuclear factor kappa B and severe hepatic necrosis may mediate systemic inflammation in choline-deficient/ethionine-supplemented diet-induced pancreatitis [J]. Pancreas, 2006, 33 (3) :260-267.
10. Tsai P S, Chen C C, Yang L C, et al. Heme oxygenase 1, nuclear factor E 2 - related factor 2, and nuclear factor kappaB are involved in hemin inhibition of type 2 cationic amino acid transporter expression and L-Arginine transport in stimulated macrophages [J]. Anesthesiology, 2006, 1 05 (6) : 1 20 1 - 1210.