Vpu matchmakers as a therapeutic strategy for HIV infection

PLoS Pathogens

Volumn 5, Issue 5, 2009, Pages

  Montal, Mauricio ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; MEMBRANE PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PEPTIDOMIMETIC AGENT; POTASSIUM CHANNEL; PROTEIN INHIBITOR; TETHERIN; UNCLASSIFIED DRUG; VPU PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; PEPTIDE FRAGMENT; VIRUS PROTEIN; VPU PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALPHA HELIX; CD4+ T LYMPHOCYTE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFLUENZA VIRUS A; NONHUMAN; NOTE; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; VIRION; ARTICLE; CHEMISTRY; HUMAN;

HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS PROTEINS; HUMANS; MEMBRANE PROTEINS; PEPTIDE FRAGMENTS; VIRAL REGULATORY AND ACCESSORY PROTEINS;

EID: 67249093700     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000246     Document Type: Note

References (30)

1. Fauci AS, Johnston MI, Dieffenbach CW, Burton DR, Hammer SM, Hoxie JA, et al. (2008) HIV vaccine research: the way forward. Science 321: 530-532.
2. Malim MH, Emerman M (2008) HIV-1 accessory proteins-ensuring viral survival in a hostile environment. Cell Host Microbe 3: 388-398. (Pubitemid 351784365)
3. Strebel K (2007) HIV accessory genes Vif and Vpu. Adv Pharmacol 55: 199-232.
4. Marassi FM, Ma C, Gratkowski H, Straus SK, Strebel K, Oblatt-Montal M, et al. (1999) Correlation of the structural and functional domains in the membrane protein Vpu from HIV-1. Proc Natl Acad Sci USA 96: 14336-14341. (Pubitemid 30000651)
5. Schubert U, Bour S, Ferrer-Montiel AV, Montal M, Maldarell F, Strebel K (1996) The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains. J Virol 70: 809-819. (Pubitemid 26028996)
6. Schubert U, Ferrer-Montiel AV, Oblatt-Montal M, Henklein P, Strebel K, Montal M (1996) Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1-infected cells. FEBS Lett 398: 12-18. (Pubitemid 26400334)
7. Becker CF, Oblatt-Montal M, Kochendoerfer GG, Montal M (2004) Chemical synthesis and single channel properties of tetrameric and pentameric TASPs (template-assembled synthetic proteins) derived from the transmembrane domain of HIV virus protein u (Vpu). J Biol Chem 279: 17483-17489. (Pubitemid 38560511)
8. Lopez CF, Montal M, Blasie JK, Klein ML, Moore PB (2002) Molecular dynamics investigation of membrane-bound bundles of the channel-forming transmembrane domain of viral protein U from the human immunodeficiency virus HIV-1. Biophys J 83: 1259-1267. (Pubitemid 34977701)
9. Park SH, Mrse AA, Nevzorov AA, Mesleh MF, Oblatt-Montal M, Montal M, et al. (2003) Three-dimensional structure of the channel-forming trans-membrane domain of virus protein "u" (Vpu) from HIV-1. J Mol Biol 333: 409-424.
10. Neil SJ, Zang T, Bieniasz PD (2008) Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature 451: 425-430. (Pubitemid 351158893)
11. VanDamme N, Goff D, Katsura C, Jorgenson RL, Mitchell R, Johnson MC, et al. (2008) The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe 3: 245-252.
12. Dyson HJ, Wright PE (2005) Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol 6: 197-208. (Pubitemid 40314921)
13. Goto T, Kennel SJ, Abe M, Takishita M, Kosaka M, Solomon A, et al. (1994) A novel membrane antigen selectively expressed on terminally differentiated human B cells. Blood 84: 1922-1930. (Pubitemid 24286144)
14. Maldarelli F, Chen MY, Willey RL, Strebel K (1993) Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein. J Virol 67: 5056-5061. (Pubitemid 23215991)
15. Montal M (2003) Structure-function correlates of Vpu, a membrane protein of HIV-1. FEBS Lett 552: 47-53. (Pubitemid 37103008)
16. Oiki S, Madison V, Montal M (1990) Bundles of amphipathic transmembrane alpha-helices as a structural motif for ion-conducting channel proteins: studies on sodium channels and acetylcholine receptors. Proteins 8: 226-236. (Pubitemid 20363307)
17. Hout DR, Gomez ML, Pacyniak E, Gomez LM, Fegley B, Mulcahy ER, et al. (2006) Substitution of the transmembrane domain of Vpu in simian-human immunodeficiency virus (SHIVKU1bMC33) with that of M2 of influenza A results in a virus that is sensitive to inhibitors of the M2 ion channel and is pathogenic for pig-tailed macaques. Virology 344: 541-559. (Pubitemid 43049638)
18. Stouffer AL, Acharya R, Salom D, Levine AS, Di Costanzo L, Soto CS, et al. (2008) Structural basis for the function and inhibition of an influenza virus proton channel. Nature 451: 596-599. (Pubitemid 351186271)
19. Schnell JR, Chou JJ (2008) Structure and mechanism of the M2 proton channel of influenza A virus. Nature 451: 591-595. (Pubitemid 351186272)
20. Hsu K, Seharaseyon J, Dong P, Bour S, Marban E (2004) Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel. Mol Cell 14: 259-267. (Pubitemid 38515652)
21. Munch J, Standker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, et al. (2007) Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. Cell 129: 263-275. (Pubitemid 46574967)
22. Xu Y, Lu H, Kennedy JP, Yan X, McAllister LA, Yamamoto N, et al. (2006) Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation. J Comb Chem 8: 531-539. (Pubitemid 44116116)
23. Xu Y, Shi J, Yamamoto N, Moss JA, Vogt PK, Janda KD (2006) A credit-card library approach for disrupting protein-protein interactions. Bioorg Med Chem 14: 2660-2673. (Pubitemid 43343655)
24. Kochendoerfer GG, Jones DH, Lee S, Oblatt-Montal M, Opella SJ, Montal M (2004) Functional characterization and NMR spectroscopy on full-length Vpu from HIV-1 prepared by total chemical synthesis. J Am Chem Soc 126: 2439-2446. (Pubitemid 38295727)
25. Kupzig S, Korolchuk V, Rollason R, Sugden A, Wilde A, Banting G (2003) Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology. Traffic 4: 694-709. (Pubitemid 37168591)
26. Yin H, Slusky JS, Berger BW, Walters RS, Vilaire G, Litvinov RI, et al. (2007) Computational design of peptides that target transmembrane helices. Science 315: 1817-1822. (Pubitemid 46580135)
27. Grueninger D, Treiber N, Ziegler MO, Koetter JW, Schulze MS, Schulz GE (2008) Designed protein-protein association. Science 319: 206-209.
28. Tai KK, Blondel le SE, Ostresh JM, Houghten RA, Montal M (2001) An N-methyl-D-aspartate receptor channel blocker with neuroprotective activity. Proc Natl Acad Sci USA 98: 3519-3524. (Pubitemid 32220877)
29. Canaves JM, Montal M (1998) Assembly of a ternary complex by the predicted minimal coiled-coil-forming domains of syntaxin, SNAP-25, and synaptobrevin. A circular dichroism study. J Biol Chem 273: 34214-34221. (Pubitemid 129758364)
30. Jouvenet N, Bieniasz PD, Simon SM (2008) Imaging the biogenesis of individual HIV-1 virions in live cells. Nature 454: 236-240. (Pubitemid 351969887)