Myxopyronin: A punch in the jaws of bacterial RNA polymerase

Future Microbiology

Volumn 4, Issue 2, 2009, Pages 145-149

  Tupin, Audrey ^a   Gualtieri, Maxime ^a   Brodolin, Konstantin ^a   Leonetti, Jean Paul ^a  

^a UNIV MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; LIPIARMYCIN; MICROCIN J25; MYXOPYRONIN; MYXOPYRONIN B; MYXOPYRONIN DERIVATIVE; NORMYXOPYRONIN; RIFAMPICIN; RNA POLYMERASE; RNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CLINICAL TRIAL; DNA TEMPLATE; DRUG BINDING SITE; DRUG DESIGN; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME STRUCTURE; GEL MOBILITY SHIFT ASSAY; HUMAN; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RNA SYNTHESIS; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION TERMINATION; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS);

EID: 67149139590     PISSN: 17460913     EISSN: None     Source Type: Journal    
DOI: 10.2217/17460913.4.2.145     Document Type: Article

References (13)

1. Belogurov GA, Vassylyeva MN, Sevostyanova A et al.: Transcription inactivation through local refolding of the RNA polymerase structure. Nature 457, 332-335 (2008).
2. Mukhopadhyay J, Das K, Ismail S et al.: The RNA polymerase 'switch region' is a target for inhibitors. Cell 135, 295-307 (2008).
3. Reichenbach H: Myxobacteria, producers of novel bioactive substances. J. Ind. Microbiol. Biotechnol. 27, 149-156 (2001).
4. Irschik H, Gerth K, Höfle G et al.: The myxopyronins, new inhibitors of bacterial RNA synthesis from Myxococcus fulvus (Myxobacterales). J. Antibiot. (Tokyo) 36, 1651-1658 (1983).
5. Irschik H, Jansen R, Höfle G et al.: The corallopyronins, new inhibitors of bacterial RNA synthesis from Myxobacteria. J. Antibiot. (Tokyo) 38, 145-152 (1985).
6. Lira R, Xiang AX, Doundoulakis T et al.: Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase. Bioorg. Med. Chem. Lett. 17, 6797-6800 (2007).
7. Murakami KS, Masuda S, Darst SA: Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 Å resolution. Science 296, 1280-1284 (2002).
8. Zhang G, Campbell E, Minakhin L et al.: Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 Å resolution. Cell 9, 811-824 (1999).
9. Vassylyev DG, Sekine S, Laptenko O et al.: Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 Å resolution. Nature 417, 712-719 (2002).
10. McClure WR, Cech CL: On the mechanism of rifampicin inhibition of RNA synthesis. J. Biol. Chem. 253, 8949-8956 (1978).
11. Nechaev S, Chlenov M, Severinov K: Dissection of two hallmarks of the open promoter complex by mutation in an RNA polymerase core subunit. J. Biol. Chem. 275, 25516-25522 (2000).
12. Irschik H, Augustiniak H, Gerth K et al.: The ripostatins, novel inhibitors of eubacterial RNA polymerase isolated from myxobacteria. J. Antibiot. (Tokyo) 48, 787-792 (1995).
13. Villain-Guillot P, Bastide L, Gualtieri M et al.: Progress in targeting bacterial transcription. Drug Discov. Today 12, 200-208 (2007).