Design, synthesis and histamine H1-receptor antagonistic activity of some novel 4-amino-2-(substituted)-5-(substituted)aryl-6- [(substituted aryl)amino]pyrimidines

Arzneimittel-Forschung/Drug Research

Volumn 59, Issue 5, 2009, Pages 243-247

  Chhabria, Mahesh T ^a   Patel, Vimal T ^a   Rajan, Kombu S ^a   Brahmkshatriya, Pathik S ^a  

^a L M COLLEGE OF PHARMACY   (India)

Author keywords

4 Aminopyrimidines; Antihistamines; Histamine antagonists; Histamine H 1 receptor antagonists, anticholinergic effects, sedative potential

Indexed keywords

ACETONITRILE DERIVATIVE; AMIDINE; CETIRIZINE; DIPHENHYDRAMINE; HISTAMINE H1 RECEPTOR ANTAGONIST; ISOTHIOCYANIC ACID; MEPYRAMINE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL TISSUE; ANTICHOLINERGIC EFFECT; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG POTENCY; DRUG SYNTHESIS; EXPERIMENTAL MODEL; GUINEA PIG; ILEUM CONTRACTION; INFRARED RADIATION; MOUSE; MUSCLE ISOTONIC CONTRACTION; NONHUMAN; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RECEPTOR BLOCKING; SEDATION; SUBSTITUTION REACTION;

EID: 67149128280     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296392     Document Type: Article

References (12)

1. Ash ASF, Schild HO. Receptors mediating some actions of histamine. Br J Pharmacol. 1966;27:427-439. (Pubitemid 127732601)
2. 3 receptor agonists and antagonists. Trends Pharmacol Sci. 1998;19:177-183.
3. Bugiani M, Carosso A, Piccioni P, Migliore E, Corsico A, Ferrari M et al . Prevalence of allergic rhinitis in young adults in Italy. Int Cong Series. 2003; 1240:497-501.
4. Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J. Allergy Clin. Immunol . 2001;108:S147-S334.
5. Scadding GK. Clinical assessment of antihistamines in rhinitis. Clin Exp Allergy. 1999;29(Suppl 3):77-81. (Pubitemid 29333338)
6. Kay GG. The effects of antihistamines on cognition and performance. J. Allergy Clin Immunol. 2000;105:S622-627. (Pubitemid 30399797)
7. Schultz A, Stuck BA, Feuring M, Hormann K, Wehling M. Novel approaches in the treatment of allergic rhinitis. Curr Opin Allergy Clin Immunol. 2003;3:21-27. (Pubitemid 36159344)
8. DuBuske LM. Second-generation antihistamines: the risk of ventricular arrhythmias. Clin Ther. 1999;21:281-295. (Pubitemid 29157787)
9. Augustin M, Rudorf W-D, Schmidt U. Thiophene durch Salkylierung. Tetrahedron, 1976;32:3055-3061.
10. Abe T, Omata T, Yoshida K, Matsumura, T, Ikeda Y, Segawa Y et al. Antiallergic effect of ZCR-2060: antihistaminic action. Jpn J Pharmacol. 1994;66:87-94. (Pubitemid 24326186)
11. Ghosh MN. Quantitative study of the antagonist on isolated preparation. In: Fundamentals of Experimental Pharmacology, 2nd ed., Calcutta: Scientific Book Agency; 1984. p. 60-63.
12. 1 receptor antagonists. Arzneimittelforschung. 1986;36:895-899.