Can baseline magnetic resonance angiography (MRA) status become a foremost factor in selecting optimal acute stroke patients for recombinant tissue plasminogen activator (rt-PA) thrombolysis beyond 3 hours?

Neurological Research

Volumn 31, Issue 4, 2009, Pages 355-361

  Ma, Li ^a   Gao, Pei Yi ^a   Lin, Yan ^a   Xue, Jing ^a   Wang, Xiao Chun ^a   Wang, Yong Jun ^a   Wang, Yi Long ^a   Liao, Xiao Ling ^a   Liu, Mei Li ^b   Cui, Shi Ming ^b   Yu, Lan ^b   Tong, Sui Jun ^c   Huang, Yuan Liang ^c   Zhou, Yu Ming ^c  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b Tianjin Huanhu Hospital   (China)

^c Xiamen First Hospital   (China)

Author keywords

Magnetic resonance imaging; Stroke; Thrombolytic therapy

Indexed keywords

ALTEPLASE;

ADULT; AGED; ARTICLE; BLOOD CLOT LYSIS; CEREBROVASCULAR ACCIDENT; CLINICAL FEATURE; CONTROLLED STUDY; DIFFUSION WEIGHTED IMAGING; DISEASE CLASSIFICATION; FEMALE; HUMAN; MAGNETIC RESONANCE ANGIOGRAPHY; MAJOR CLINICAL STUDY; MALE; OCCLUSIVE CEREBROVASCULAR DISEASE; PERFUSION WEIGHTED IMAGING; RANKIN SCALE; SYMPTOMATOLOGY; TREATMENT OUTCOME;

ADULT; AGED; FEMALE; FIBRINOLYTIC AGENTS; FOLLOW-UP STUDIES; HUMANS; MAGNETIC RESONANCE ANGIOGRAPHY; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PATIENT SELECTION; PERFUSION IMAGING; SEVERITY OF ILLNESS INDEX; STROKE; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME; YOUNG ADULT;

EID: 67149128097     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/174313209X444044     Document Type: Article

References (26)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333: 1581-1587
2. Marler JR, Tilley BC, Lu M, et al. Early stroke treatment associated with better outcome: The NINDS rt-PA stroke study. Neurology 2000; 55: 1649-1655
3. Hacke W, Brott T, Caplan L, et al. Thrombolysis in acute ischemic stroke: Controlled trials and clinical experience. Neurology 1999; 53: S3-S14 (Pubitemid 29491978)
4. Ringleb PA, Schellinger PD, Scheranz C, et al. Thrombolytic therapy within 3 to 6 hours after onset of ischemic stroke useful or harmful? Stroke 2002; 33: 1437-1441
5. Albers GW. Expanding the window for thrombolysis therapy in acute stroke. The potential role of acute MRI for patient selection. Stroke 1999; 30: 2230-2237
6. Schellinger PD, Thomalla G, Fiehler J. MRI-based and CT-based thrombolytic therapy in acute stroke within and beyond established time windows: An analysis of 1210 patients. Stroke 2007; 38: 2640-2645 (Pubitemid 47493997)
7. Albers GW, Thijs VN, Wechsler L. Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol 2006; 60: 508-517 (Pubitemid 44871793)
8. Hjort N, Butcher K, Davis SM. Magnetic resonance imaging criteria for thrombolysis in acute cerebral infarct. Stroke 2005; 36: 388-397 (Pubitemid 40170827)
9. Haefelin TN, Wittsack HJ, Wenserski F. Diffusion- and perfusion-weighted MRI: The DWI/PWI mismatch region in acute stoke. Stroke 1999; 30: 1591-1597 (Pubitemid 29379608)
10. Lovblad KO, El-Koussy M, Oswald H. Magnetic resonance imaging of the ischaemic penumbra. Swiss Med Wkly 2003; 133: 551-559 (Pubitemid 37504957)
11. Kidwell CS, Alger JR, Saver JL. Evolving paradigms in neuroimaging of the ischemic penumbra. Stroke 2004; 35 (Suppl. I): S2662-S2665 (Pubitemid 39461995)
12. Kidwell CS, Alger JR, Saver JL. Beyond mismatch evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging. Stroke 2003; 34: 2729-2735 (Pubitemid 37392775)
13. Sobesky J, Weber ZO, Lehnhardt FG. Does the mismatch match the penumbra? Magnetic resonance imaging and positron emission tomography in early ischemic stroke. Stroke 2005; 36: 980-985 (Pubitemid 40629288)
14. Kidwell CS, Alger JR, di Salle F. Diffusion MRI in patients with transient ischemic attacks. Stroke 1999; 30: 1174-1180 (Pubitemid 29259169)
15. Kidwell CS, Saver JL, Mattiello J. Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol 2000; 47: 462-469 (Pubitemid 30194602)
16. Kidwell C S, Saver JL, Starkman S. Late secondary ischemic injury in patients receiving intraarterial thrombolysis. Ann Neurol 2002; 52: 698-703 (Pubitemid 35403178)
17. Guadagno JV, Warburton EA, Jones PS. How affected is oxygen metabolism in DWI lesions? A combined acute stroke PET-MR study. Neurology 2006; 67: 824-829 (Pubitemid 44394197)
18. Ringer TM, Neumann-Haefelin T, Sobel RA. Cerebral ischemia abnormalities does not necessarily reflect tissue salvage in experimental reversal of early diffusion-weighted magnetic resonance imaging. Stroke 2001; 32: 2362-2369 (Pubitemid 32954809)
19. Barber PA, Darby DG, Desmond PM. Prediction of stroke outcome with echoplanar perfusion- and diffusion-weighted MRI. Neurology 1998; 51: 418-426 (Pubitemid 28406316)
20. Neumann-Haefelin T, Wittsack HJ, Fink GR. Diffusion- and perfusion-weighted MRI: Influence of severe carotid artery stenosis on the PWI/DWI mismatch in acute stroke. Stroke 2003; 31: 1311-1317
21. Grandin CB, Duprez TP, Smith AM. Usefulness of magnetic resonance-derived quantitative measurements of CBF and CBV in prediction of infarct growth in hyperacute stroke. Stroke 2001; 32: 1147-1153 (Pubitemid 32825799)
22. Paciaroni M, Agnelli G, Corea F. Early hemorrhagic transformation of brain infarction: Rate, predictive factors, and influence on clinical outcome: Results of a prospective multicenter study. Stroke 2008; 39: 2249-2256
23. Schellinger PD, Jansen O, Fiebach JB, et al. Monitoring intravenous recombinant tissue plasminogen activator thrombolysis for acute ischemic stroke with diffusion and perfusion MRI. Stroke 2000; 31: 1318-1328 (Pubitemid 30351252)
24. Ohue S, Kohno K, Kusunoki K. Magnetic resonance angiography in patients with acute stroke treated by local thrombolysis. Neuroradiology 1998; 40: 536-540 (Pubitemid 28396025)
25. Rordorf G, Koroshetz WJ, Copen WA. Regional ischemia and ischemic injury in patients with acute middle cerebral artery stroke as defined by early diffusion-weighted and perfusion-weighted MRI. Stroke 1998; 29: 939-943 (Pubitemid 28228153)
26. Torres-Mozqueda F, He J, Yeh IB. An acute ischemic stroke classification instrument that includes CT or MR angiography: The Boston Acute Stroke Imaging Scale. AJNR Am J Neuroradiol 2008; 29: 1111-1117 (Pubitemid 351954877)