Bone penetration of amoxicillin and clavulanic acid evaluated by population pharmacokinetics and Monte Carlo simulation

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 6, 2009, Pages 2569-2578

  Landersdorfer, Cornelia B ^a,e   Kinzig, Martina ^a   Bulitta, Jürgen B ^a,e   Hennig, Friedrich F ^b   Holzgrabe, Ulrike ^c   Sörgel, Fritz ^a,d   Gusinde, Johannes ^b  

^a IBMP Institute for Biomedical and Pharmaceutical Research   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

^e UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; MOXIFLOXACIN;

AREA UNDER THE CURVE; ARTICLE; CANCELLOUS BONE; CLINICAL ARTICLE; CORTICAL BONE; DRUG BLOOD LEVEL; DRUG BONE LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG PENETRATION; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MINIMUM INHIBITORY CONCENTRATION; MONTE CARLO METHOD; PHARMACODYNAMICS; PRIORITY JOURNAL; SINGLE DRUG DOSE; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STEADY STATE; TANDEM MASS SPECTROMETRY; TOTAL HIP PROSTHESIS;

ADULT; AGED; AMOXICILLIN; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; BONE AND BONES; CLAVULANIC ACID; FEMALE; HUMANS; MALE; MIDDLE AGED; MONTE CARLO METHOD; OSTEOMYELITIS;

EID: 67049145574     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01119-08     Document Type: Article

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