Effects of Chronic Exposure to Crack Cocaine on the Respiratory Tract of Mice

Toxicologic Pathology

Volumn 37, Issue 3, 2009, Pages 324-332

  Herculiani, Percyleine P ^a,b   Pires Neto, Ruy C ^a   Bueno, Heloisa M S ^a   Zorzetto, Júlio C ^a   Silva, Luiz C ^c   Santos, A B G ^a   Garcia, Raphael C T ^a   Yonamine, Mauricio ^a   Detregiachi, Cláudia R P ^b   Saldiva, Paulo H N ^a   Mauad, Thais ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Marília University UNIMAR   (Brazil)

^c Marília Medical School   (United Kingdom)

Author keywords

airway; crack cocaine; epithelium; lung; macrophages; mouse; nose

Indexed keywords

ALCIAN BLUE; COCAINE; COLORING AGENT; HEMOSIDERIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BLOOD; BRONCHIOLE; CHEMISTRY; DRUG EFFECT; EPITHELIUM CELL; EXPOSURE; IMMUNOHISTOCHEMISTRY; INHALATIONAL DRUG ADMINISTRATION; LUNG ALVEOLUS MACROPHAGE; MALE; METABOLISM; METHODOLOGY; MOUSE; NOSE; PERIODIC ACID SCHIFF STAIN; RESPIRATORY SYSTEM; TOXICITY TESTING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL WALL THICKNESS; BRONCHUS MUCOSA; CELL DENSITY; CONTROLLED STUDY; HISTOPATHOLOGY; INHALATION; LONG TERM EXPOSURE; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; MORPHOMETRICS; MUCUS; NONHUMAN; NOSE CAVITY; NOSE MUCOSA; PRIORITY JOURNAL; PULMONARY ARTERY; SMOKE; VASOCONSTRICTION;

ADMINISTRATION, INHALATION; ALCIAN BLUE; ANIMALS; BRONCHIOLES; COLORING AGENTS; CRACK COCAINE; EPITHELIAL CELLS; HEMOSIDERIN; IMMUNOHISTOCHEMISTRY; INHALATION EXPOSURE; MACROPHAGES, ALVEOLAR; MALE; MICE; MICE, INBRED BALB C; NOSE; PERIODIC ACID-SCHIFF REACTION; RESPIRATORY SYSTEM; TOXICITY TESTS, CHRONIC;

ANIMALIA; MUS;

EID: 67049133079     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/0192623308330790     Document Type: Article

References (41)

1. Albertson TE Walby WF Derlet RW Stimulant-induced pulmonary toxicity Chest 1995 108 1140 49
2. Bailey ME Fraire AE Greenberg SD Barnard J Cagle PT Pulmonary histopathology in cocaine abusers Hum Pathol 1994 25 203 7
3. Baldwin GC Choi R Roth MD Shay AH Kleerup EC Simmons MS Tashkin DP Evidence of chronic damage to the pulmonary microcirculation in habitual users of alkaloidal (‘‘Crack’’) cocaine Chest 2002 121 1231 38
4. Baldwin GC Tashkin DP Buckley DM Park AN Dubinett SM Roth MD Marijuana and cocaine impair alveolar macrophage function and cytokine production Am J Respir Crit Care Med 1997 156 1606 13
5. Barroso-Moguel R Villeda-Hernandez J Mendez-Armenta M Santamaria A Galvan-Arzate S Alveolar lesions induced by systemic administration of cocaine to rats Toxicol Lett 1999 110 113 18
6. Batalha JRF Saldiva PHN Clarke RW Couli BA Stearns RC Lawrence J Murthy GGK Koutrakis P Godleski JJ Concentrated ambient air particles induce vasoconstriction of small pulmonary arteries in rats Environ Health Perspect 2002 110 1191 97
7. Björk M Pettersson KJ Osterlof G Capillary gas chromatographic method for the simultaneous determination of local anaesthetics in plasma samples J Chromatogr 1990 533 229 34
8. Camargo Pires-Neto R Julia Lichtenfels A Regina Soares S Macchione M Hilario Nascimento Saldiva P Dolhnikoff M Effects of São Paulo air pollution on the upper airways of mice Environ Res 2006 101 356 61
9. Chen LC Graefe JF Shojaie J Willets J Wood RW Pulmonary effects of the cocaine pyrolysis product, methylecgonidine, in guinea pigs Life Sci 1995 56 7 12
10. Collins SL Evans SM Foltin RW Haney M Intranasal cocaine in humans: effects of sex and menstrual cycle Pharmacol Biochem Behav 2007 86 117 24
11. De Magalhães Simões S dos Santos MA da Silva Oliveira M Fontes ES Fernezlian S Garippo AL Castro I Castro FF de Arruda Martins M Saldiva PH Mauad T Dolhnikoff M Inflammatory cell mapping of the respiratory tract in fatal asthma Clin Exp Allergy 2005 35 602 11
12. Egred M Davis GK Cocaine and the heart Postgrad Med J 2005 81 568 71
13. Ferreira Filho OF Turchi MD Laranjeira R Castelo A Epidemiological profile of cocaine users on treatment in psychiatrics hospitals, Brazil Rev Saude Publica 2003 37 751 59
14. Fligiel SE Roth MD Kleerup EC Barsky SH Simmons MS Tashkin DP Tracheobronchial histopathology in habitual smokers of cocaine, marijuana, and/or tobacco Chest 1997 112 319 26
15. Gallouj K Brichet A Lamblin C Wallaert B Syndrome hémorragique pulmonaire après inhalation de cocaïne Rev Mal Respir 1999 16 560 62
16. Guindalini C Vallada H Breen G Laranjeira R Concurrent crack and powder cocaine users from Sao Paulo: do they represent a different group? BMC Public Health 2006 20 6 10
17. Haim DY Lippmann L Goldberg SK Walkenstein MD The pulmonary complications of crack cocaine Chest 1995 107 233 40
18. Halbower AC Mason RJ Abman SH Tuder RM Agarose infiltration improves morphology of cryostat section of lung Lab Invest 1994 71 149 53
19. Herbert RA Leininger Jr Maronpot R Nose, larynx and trachea Pathology of the Mouse: Reference and Atlas 1999 Vienna, IL Cache River Press 259 92
20. Janjua TM Bohan AE Wesselius LJ Increased lower respiratory tract iron concentrations in alkaloidal (‘‘crack’’) cocaine users Chest 2001 119 422 27
21. Jones R Reid L Secretory cells and their glycoproteins in health and disease Br Med Bull 1978 34 9 16
22. Kasahara Y Tuder RM Iarasevicience-Stewart L Le Cras TD Abman S Hirth PK Waltenberger J Voelkel NF Inhibition of VEGF receptors causes lung cell apoptosis and emphysema J Clin Invest 2000 106 1311 19
23. Kleerup EC Koyal SN Marques-Magallanes JA Goldman MD Tashkin DP Chronic and acute effects of crack cocaine on diffusing capacity, membrane diffusion, and pulmonary capillary blood volume in the lung Chest 2002 122 629 38
24. Kuhn FE Johnson MN Gillis RA Visner MS Schaer GL Effects of cocaine on the coronary circulation and systemic hemodynamics in the dog J Am Coll Cardiol 1990 16 1481 91
25. Laposata EA Mayo GL A review of pulmonary pathology and mechanisms associated with inhalation of freebase cocaine (“crack”) Am J Forensic Med Pathol 1993 14 1 9
26. Mari A Arranz C Gimeno X Lluch J Pericot J Escuder O Monner A Piulachs P Nasal cocaine abuse and centrofacial destructive process: report of three cases including treatment Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 93 435 39
27. Meleca RJ Burgio DL Carr RM Lolachi CM Mucosal injuries of the upper aerodigestive tract after smoking crack or freebase cocaine Laryngoscope 1997 107 620 25
28. Murray RJ Smialek JE Golle M Albin RJ Pulmonary artery medial hypertrophy in cocaine users without foreign particle microembolization Chest 1989 96 1050 53
29. Nassif Filho ACN Bettega SG Lunedo S Maestri JE Gortz F Repercussões otorrinolaringológicas do abuso de cocaína e/ou crack em dependentes de drogas Rev Assoc Med Brasil 1999 45 237 41
30. Prinzleve M Haasen C Zurhold H Matali JL Bruguera E Gerevich J Bacskai E Ryder N Butler S Manning V Gossop M Pezous AM Verster A Camposeragna A Andersson P Olsson B Primorac A Fischer G Guttinger F Rehm J Krausz M Cocaine use in Europe—a multi-centre study: patterns of use in different groups Eur Addict Res 2004 10 147 55
31. Putt FA Manual of histopathological staining methods 1972 New York, NY John Wiley & Sons 207
32. Restrepo CS Carrillo JA Martinez S Ojeda P Rivera AL Hatta A Pulmonary complications from cocaine and cocaine-based substances: imaging manifestations Radiographics 2007 27 941 56
33. Roth MD Whittaker K Salehi K Tashkin DP Baldwin GC Mechanisms for impaired effector function in alveolar macrophages from marijuana and cocaine smokers J Neuroimmunol 2004 147 82 86
34. Saldiva PH Clarke RW Coull BA Stearns RC Lawrence J Murthy GG Diaz E Koutrakis P Suh H Tsuda A Godleski JJ Lung inflammation induced by concentrated ambient air particles is related to particle composition Am J Respir Crit Care Med 2002 165 1610 17
35. Tashkin DP Khalsa ME Gorelick D Pulmonary status of habitual cocaine smokers Am Rev Respir Dis 1992 145 92 100
36. Thadani PV NIDA conference report on cardiopulmonary complications of ‘‘crack’’ cocaine use Chest 1996 110 1072 76
37. Tierney BP Stadelmann WK Necrotizing infection of the face secondary to intranasal impaction of ‘‘crack’’ cocaine Ann Plast Surg 1999 43 640 43
38. Vieira RP Claudino RC Duarte AC Santos AB Perini A Faria Neto HC Mauad T Martins MA Dolhnikoff M Carvalho CR Aerobic exercise decreases chronic allergic lung inflammation and airway remodeling in mice Am J Respir Crit Care Med 2007 176 871 77
39. Weibel ER Cruz-Orive LM Crystal RG West JB Morphometric methods The Lung: Scientific Foundations 1997 Philadelphia, PA Lippincott Raven Publishers 333 34
40. Weibel ER Gil J Morphometry: stereological theory and practical methods Models of Lung Disease 1990 47 New York, NY Dekker 199 252
41. Wood RW Shojaie J Fang CP Graefe JF Methylecgonidine coats the crack particle Pharmacol Biochem Behav 1996 53 57 66