Splenectomy as an adjunctive treatment for dogs with immune-mediated hemolytic anemia: Ten cases (2003-2006): Retrospective Study

Journal of Veterinary Emergency and Critical Care

Volumn 19, Issue 3, 2009, Pages 254-261

  Horgan, Jason Elliott ^a   Roberts, Brian Keith ^a   Schermerhorn, Thomas ^b  

^a Veterinary Specialists of South Florida   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

Author keywords

Autoimmune disease; Immune mediated disease; Red blood cell; Small animal surgery; Spleen

Indexed keywords

ANIMAL; ANIMAL DISEASE; ARTICLE; AUTOIMMUNE HEMOLYTIC ANEMIA; DOG; DOG DISEASE; RETROSPECTIVE STUDY; SPLENECTOMY; TIME;

ANEMIA, HEMOLYTIC, AUTOIMMUNE; ANIMALS; DOG DISEASES; DOGS; RETROSPECTIVE STUDIES; SPLENECTOMY; TIME FACTORS;

ANIMALIA; CANIS FAMILIARIS;

EID: 67049086671     PISSN: 14793261     EISSN: 14764431     Source Type: Journal    
DOI: 10.1111/j.1476-4431.2009.00419.x     Document Type: Article

References (45)

1. McCullough S. Immune-mediated hemolytic anemia: understanding the nemesis. Vet Clin North Am Small Anim Pract 2003 33 : 1295 1315. (Pubitemid 37526881)
2. Domen RE. An overview of immune hemolytic anemias. Cleve Clin J Med 1998 65 : 89 99. (Pubitemid 28090606)
3. Balch A. Canine immune-mediated hemolytic anemia: pathophysiology, clinical signs, and diagnosis. Compend Contin Educ Pract Vet 2007 29 : 217 225. (Pubitemid 46806520)
4. Akpek G, McAneny D, Weintraub L. Comparative response to splenectomy in Coombs-positive autoimmune hemolytic anemia with or without associated disease. Am J Hematol 1999 61 : 98 102. (Pubitemid 29252385)
5. Scott-Moncrieff J, Treadwell N, McCullough S, Brooks M. Hemostatic abnormalities in dogs with primary immune-mediated hemolytic anemia. J Am Anim Hosp Assoc 2001 37 : 220 227. (Pubitemid 33630060)
6. Weinkle T, Center S, Randolph J, et al. Evaluation of prognostic factors, survival rates, and treatment protocols for immune-mediated hemolytic anemia in dogs. J Am Vet Med Assoc 2005 226 : 1869 1880. (Pubitemid 40746063)
7. Reimer M, Troy G, Warnick L, et al. Immune-mediated hemolytic anemia. J Am Anim Hosp Assoc 1999 35 : 384 391.
8. Grundy S, Barton C. Influence of drug treatment on survival of dogs with immune-mediated hemolytic anemia. J Am Vet Med Assoc 2001 218 : 543 546.
9. Klag AR, Giger U, Shofer FS. Idiopathic immune-mediated hemolytic anemia in dogs. J Am Vet Med Assoc 1993 202 : 783 788.
10. Weiss DJ, Brazzell JL. Detection of activated platelets in dogs with primary immune-mediated hemolytic anemia. J Vet Intern Med 2006 20 (3) : 682 686. (Pubitemid 43774119)
11. Feldman BF, Handagama P, Lubberink A.A. Splenectomy as adjunctive therapy for immune-medicated thrombocytopenia and hemolytic anemia in the dog. J Am Vet Med Assoc 1985 187 : 617 619.
12. Jans H, Armstrong P, Price G. Therapy of immune mediated thrombocytopenia. J Vet Intern Med 1990 1 : 4 7.
13. Landaw SA. Factors that accelerate or retard red blood cell senescence. Blood Cells 1988 14 : 47 67.
14. Carr A, Panciera D, Kidd L. Prognostic factors for mortality and thromboembolism in canine immune-mediated hemolytic anemia. J Vet Intern Med 2002 16 : 504 509.
15. Stewart AF, Feldman BF. Immune mediated hemolytic anemia. Part I. An overview. Compend Contin Educ Pract Vet 1993 15 (3) : 372 381.
16. McManus PM, Craig LE. Correlation between leukocytosis and necropsy findings in dogs with immune-mediated hemolytic anemia. J Am Vet Med Assoc 2001 218 : 1308 1313. (Pubitemid 33605910)
17. Benet LZ, Øie S, Schwartz JB. Design and optimization of dosage regimens: pharmacokinetic data, In : Hardman JG, Limbird LE. eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed. New York : The McGraw Hill Companies 1996, p. 1774.
18. Diasio RB, LoBuglio AF. Immunomodulators: immunosuppressive agents and immunostimulants, In : Hardman JG, Limbird LE. eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed. New York : The McGraw Hill Companies 1996, pp. 1291 1308.
19. Duncan L. Mosby Drug Consult. St Louis : Mosby Inc 2005, pp. II-2401 II-2403, pp. II-694-695, pp. II-270-272.
20. Balch A, Mackin A. Canine immune-mediated hemolytic anemia: pathophysiology, clinical signs, and diagnosis. Compend Contin Educ Pract Vet 2007 29 : 230 238.
21. Ogilvie GK, Felsburg PJ, Harris CW. Short-term effect of cyclophosphamide and azathioprine on selected aspects of canine blastogenic response. Vet Immunol Immunopathol 1988 18 : 119 127. (Pubitemid 18128868)
22. Day M. Serial monitoring of clinical, haematological and immunological parameters in canine autoimmune haemolytic anaemia. J Small Anim Pract 1996 37 : 523 534. (Pubitemid 126459463)
23. Burgess KE. Immune-mediated hemolytic anemia in dogs: a retrospective study of 60 cases treated with cyclophosphamide. J Vet Intern Med 1997 11 : 143 148.
24. Klein MK, Dow SW, Rosychuk RAW. Pulmonary thromboembolism associated with immune-mediated hemolytic anemia in dogs: ten cases. J Am Vet Med Assoc 1989 195 : 246 250. (Pubitemid 19181275)
25. Guittard P, Cathala B, Jorda MF, et al. Massive blood transfusion in 50 seriously injured patients. Occurrence of pulmonary oedema. Anesth Analg 1981 38 : 685 688. (Pubitemid 13220639)
26. Harvey MP, Greenfield TP, Sugrue ME, et al. Massive blood transfusion in a tertiary referral hospital. Med J Austria 1995 163 : 356 359.
27. Huber-Wagner S, Qvick M, Mussack T, et al. Massive blood transfusion and outcome in 1062 polytrauma patients. Vox Sang 2007 92 : 69 78.
28. Duval D, Giger U. Vaccine-associated immune-mediated hemolytic anemia in the dog. J Vet Intern Med 1996 10 : 290 295. (Pubitemid 126709356)
29. Piek CJ, Junius G, Dekker A, et al. Idiopathic immune-mediated hemolytic anemia: treatment outcome and prognostic factors in 149 dogs. J Vet Intern Med 2008 2 : 366 373. (Pubitemid 351570502)
30. Bourgeois E, Caulier M, Delarozee C, et al. Long-term follow-up of chronic autoimmune thrombocytopenic purpura refractory to splenectomy: a prospective analysis. Br J Haematol 2003 120 : 1079 1088. (Pubitemid 36411571)
31. Dacie J. The immune haemolytic anemias: a century in exciting progress in understanding. Br J Haematol 2001 114 : 770 785. (Pubitemid 32953732)
32. Schreiber A, Atkinson J, Jaffe J, et al. Pathophysiology of immune hemolytic anemia. Ann Intern Med 1977 87 : 210 222. (Pubitemid 8165591)
33. Gibson M, Sehon JK, White S, et al. Splenectomy for idiopathic thrombocytopenic purpura: a five-year retrospective review. Am J Surg 2000 66 : 952 954.
34. Hamidah A, Thambidorai CR, Jamal R, et al. Prolonged remission after splenectomy for refractory Evans syndrome - a case report and literature review. Southeast Asian J Trop Med Public Health 2005 36 : 762 764. (Pubitemid 41316808)
35. Johansson E, Engervall P, Landgren O, et al. Response to splenectomy is durable after a certain point in time in adult patients with chronic immune thrombocytopenic purpura. Eur J Haematol 2006 0 : 1600 1609.
36. Mohren M, Markmann I, Dworschak U, et al. Thromboembolic complications after splenectomy for hematologic diseases. Am J Hematol 2004 76 : 143 114.
37. Oliveira M, Oliveira B, Murao M, et al. Clinical course of autoimmune hemolytic anemia: an observational study. J Pediat 2006 1 : 58 62.
38. Vianelli N, Monica G, Vivo A, et al. Efficacy and safety of splenectomy in immune thrombocytopenic purpura: long term results of 402 cases. Haematologica 2005 90 : 72 77. (Pubitemid 40193756)
39. Kemming G, Messick J, Mueller W, et al. Can we continue research in splenectomized dogs? Mycoplasma haemocanis: old problem - new insight. Eur Surg Res 2004 36 : 198 205. (Pubitemid 38976516)
40. Raskin RE. Hematologic parasites. In: Proceedings of the Western Veterinary Conference; 2002: Las Vegas, USA.
41. Lester S, Hume B, Phipps B. Haemobartonella canis infection following splenectomy and transfusion. Can Vet J 1995 36 : 444 445.
42. Hodam R. The risk of splenectomy. Am J Surg 1970 119 : 709 713.
43. Karakantza M, Theodorou G, Mouzaki A, et al. In vitro study of the long-term effects of post-traumatic splenectomy on cellular immunity. Scand J Immunol 2004 59 : 209 219. (Pubitemid 38253555)
44. McMillan R, Durette C. Long-term outcomes in adults with chronic ITP after splenectomy failure. Blood J 2004 104 : 956 960. (Pubitemid 39038013)
45. Spangler W, Kass P. Pathologic factors affecting postsplenectomy survival in dogs. J Vet Intern Med 1997 11 : 166 171.