Recognition and management of drug-induced cytopenias: The example of idiosyncratic drug-induced thrombocytopenia

Expert Opinion on Drug Safety

Volumn 8, Issue 2, 2009, Pages 183-190

  Andres, Emmanuel ^a   Dali Youcef, Nassim ^a   Serraj, Khalid ^b   Zimmer, Jacques ^c  

^a HÔPITAL CIVIL   (France)

^b hôpitaux universitaires de Rabat   (Morocco)

^c LUXEMBOURG INSTITUTE OF HEALTH   (Luxembourg)

Author keywords

Cytopenia; Drug induced thrombocytopenia; Drugs; Thrombocytopenia

Indexed keywords

ANALGESIC AGENT; ANTICONVULSIVE AGENT; ANTIDIABETIC AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTIVIRUS AGENT; BENZENE DERIVATIVE; CARDIOVASCULAR AGENT; COLCHICINE; COTRIMOXAZOLE; DIGITALIS; FOLIC ACID ANTAGONIST; GEMCITABINE; GOLD SALT; HEPARIN; INTERFERON; METHYLDOPA; MITOMYCIN; PSYCHOTROPIC AGENT; QUINIDINE; QUININE; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RIFAMPICIN; SULFONAMIDE; THIAZIDE DIURETIC AGENT; TICLOPIDINE; TOLBUTAMIDE; UNINDEXED DRUG; VALPROIC ACID; VANCOMYCIN; VERAPAMIL; CORTICOSTEROID; DRUG; IMMUNOGLOBULIN;

ANAMNESIS; ANTIBODY PRODUCTION; ANTIBODY SCREENING; ANTIGEN BINDING; BLEEDING; BLOOD SMEAR; BONE MARROW SUPPRESSION; CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; DISEASE SEVERITY; DRUG INDICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HEMOLYTIC ANEMIA; HUMAN; IDIOSYNCRATIC DRUG INDUCED THROMBOCYTOPENIA; IMMUNE RESPONSE; INCIDENCE; MEMBRANE BINDING; MUCOSAL BLEEDING; PATHOGENESIS; PATHOPHYSIOLOGY; REVIEW; SEROLOGY; SKIN BLEEDING; SYSTEMATIC REVIEW; THROMBOCYTE COUNT; THROMBOCYTE DYSFUNCTION; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS; THROMBOTIC THROMBOCYTOPENIC PURPURA; TREATMENT INDICATION; WESTERN BLOTTING; CHEMICALLY INDUCED DISORDER; HOSPITALIZATION; PLASMAPHERESIS; PROGNOSIS; RISK FACTOR; THROMBOCYTE TRANSFUSION;

ADRENAL CORTEX HORMONES; HUMANS; IMMUNOGLOBULINS; PHARMACEUTICAL PREPARATIONS; PLASMAPHERESIS; PLATELET TRANSFUSION; PROGNOSIS; RISK FACTORS; SEVERITY OF ILLNESS INDEX; THROMBOCYTOPENIA;

EID: 66949167813     PISSN: 14740338     EISSN: None     Source Type: Journal    
DOI: 10.1517/14740330902784162     Document Type: Review

References (49)

1. Andrès E, Federici L, Weitten T, et al. Recognition and management of drug-induced blood-cytopenias: the example of drug-induced acute neutropenia and agranulocytosis. Drug Saf 2008;7:481-489
2. French national internet website of pharmacovigilance. Available from: http://www.centres-pharmacovigilance.net/
3. Aster RH, Bougie DW. Drug-induced immune thrombocytopenia. N Engl J Med 2007;357:580-587 • A recent review of drug-induced thrombocytopenia. (Pubitemid 47236283)
4. Visentin GP, Liu CY. Drug-induced thrombocytopenia. Hematol Oncol Clin North Am 2007;21:685-696
5. George JN, Raskob GE, Shah SR, et al. Drug-induced thrombocytopenia. A systematic review of published case reports. Ann Intern Med 1998;129:886-890
6. Li X, Swisher KK, Vesely SK, George JN. Drug-induced thrombocytopenia: an updated systematic review, 2006. Drug Saf 2007;30:185-186 •• A recent systematic review of all published cases of drug-induced thrombocytopenia.
7. van den Bemt PM, Meyboom RH, Egberts AC. Drug-induced immune thrombocytopenia. Drug Saf 2004;27:1243-1252 (Pubitemid 40066085)
8. Godeau B, Bierling P. Thrombopénies. In: Encyclopédie Pratique de Médecine, Encycl Méd Chir (Elsevier, Paris), AKOS 4-0080, 1998. p. 5
9. Murphy WG, Kelton JG. Idiosyncratic drug-induced thrombocytopenia. Curr Stud Hematol Blood Transfus 1988;54:71-88 (Pubitemid 18035441)
10. Theophile H, Begaud B, Martin K, et al. Incidence of agranulocytosis in Southwest France. Eur J Epidemiol 2004;19:563-565 (Pubitemid 39005418)
11. Kaufman DW, Kelly JP, Johannes CB, et al. Acute thrombocytopenic purpura in relation to the use of drugs. Blood 1993;82:2714-2718 (Pubitemid 23318077)
12. Aster RH. Drug-induced immune thrombocytopenia: an overview of pathogenesis. Semin Hematol 1999;36:2-6 (Pubitemid 29045503)
13. Carey PJ. Drug-induced myelosuppression: diagnosis and management. Drug Saf 2003;26:691-706 (Pubitemid 36976131)
14. Rutherford CJ, Frenkel EP. Thrombocytopenia. Issues in diagnosis and therapy. Med Clin North Am 1994;78:555-575
15. Saif MW, McGee PJ. Hemolytic-uremic syndrome associated with gemcitabine: a case report and review of literature. JOP 2005;6:369-374 (Pubitemid 41581760)
16. Greinacher A, Eichler P, Lubenow N, Kiefel V. Drug-induced and drug-dependent immune thrombocytopenias. Rev Clin Exp Hematol 2001;5:166-200 (Pubitemid 34947702)
17. Aster RH. Drug-induced immune cytopenias. Toxicology 2005;209:149-153 (Pubitemid 40568642)
18. Batchelor FR, Dewdney JM, Gazzard D. Penicillin allergy: the formation of the penicilloyl determinant. Nature 1965;206:362-364
19. Weltzien HU, Padovan E. Molecular features of penicillin allergy. J Invest Dermatol 1998;110:203-206 (Pubitemid 28144591)
20. Garratty G. Immune cytopenia associated with antibiotics. Transfus Med Rev 1993;7:255-267 (Pubitemid 23297289)
21. dem Borne AE, Pegels JG, van der Stadt RJ, et al. Thrombocytopenia associated with gold therapy: a drug-induced autoimmune disease? Br J Haematol 1986;63:509-516 (Pubitemid 16033571)
22. Romagnoli P, Spinas GA, Sinigaglia F. Gold-specific T cells in rheumatoid arthritis patients treated with gold. J Clin Invest 1992;89:254-258
23. Curtis BR, Divgi A, Garritty M, Aster RH. Delayed thrombocytopenia after treatment with abciximab: a distinct clinical entity associated with the immune response to the drug. J Thromb Haemost 2004;2:985-992 (Pubitemid 40185747)
24. McCorry RB, Johnston P. Fatal delayed thrombocytopenia following abciximab therapy. J Invasive Cardiol 2006;18:173-174 (Pubitemid 44680987)
25. Bougie DW, Wilker PR, Wuitschick ED, et al. Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa. Blood 2002;100:2071-2076 (Pubitemid 35001239)
26. Brassard JA, Curtis BR, Cooper RA, et al. Acute thrombocytopenia in patients treated with the oral glycoprotein IIb/IIIa inhibitors xemilofiban and orbofiban: evidence for an immune etiology. Thromb Haemost 2002;88:892-897 (Pubitemid 36018772)
27. Arepally GM, Ortel TL. Heparin-induced thrombocytopenia. N Engl J Med 2006;355:809-817 • A review of heparin-induced thrombocytopenia. (Pubitemid 44285586)
28. Aster R. Drug-induced thrombocytopenia. In: Michelson AD, editor, Platelets. New York: Academic Press, 2007. p. 887-902
29. Warkentin TE. Thrombocytopenia due to platelet destruction and hypersplenism. Fourth edition. In: Hoffman R, Benz EJ Jr, Shattil SJ, et al., editors, Hematology: basic principles and practice. Philadelphia: Elsevier, 2005. p. 2305-2325
30. Brinker AD, Beitz J. Spontaneous reports of thrombocytopenia in association with quinine: clinical attributes and timing related to regulatory action. Am J Hematol 2002;70:313-317 (Pubitemid 34810509)
31. Reddy JC, Shuman MA, Aster RH. Quinine/quinidine-induced thrombocytopenia: a great imitator. Arch Intern Med 2004;164:218-220 (Pubitemid 38140410)
32. Freiman JP. Fatal quinine-induced thrombocytopenia. Ann Intern Med 1990;112:308-309 (Pubitemid 20055362)
33. World internet reference website on platelet disorders (Jame Bussel). Available from: http://w3.ouhsc.edu/platelets/index.html
34. Brace LD. Thrombocytopenia. Clin Lab Sci 2007;20:38-47
35. Marcelli-Barge A. Thrombopénies et leucopénies immunoallergiques d'origine médicamenteuse. Rev Fr Transf Hemobiol 1989;32:115-134
36. Freiman JP. Fatal quinine-induced thrombocytopenia. Ann Intern Med 1990;112:308-309 (Pubitemid 20055362)
37. Portielje JE, Westendorp RG, Kluin-Nelemans HC, Brand A. Morbidity and mortality in adults with idiopathic thrombocytopenic purpura. Blood 2001;97:2549-2554
38. Wazny LD, Ariano RE. Evaluation and management of drug-induced thrombocytopenia in the acutely ill patient. Pharmacotherapy 2000;20:292-307 (Pubitemid 30140747)
39. Greinacher A, Eichler P, Lubenow N, Kiefel V. Drug-induced and drug-dependent immune thrombocytopenias. Rev Clin Exp Hematol 2001;5:166-200 (Pubitemid 34947702)
40. Vicari A, Banfi G, Bonini PA. EDTA-dependent pseudothrombocytopaenia. A 12-month epidemiological study. Scand J Clin Lab Invest 1988;48:537-542 (Pubitemid 18236038)
41. Visentin GP, Wolfmeyer K, Newman PJ, Aster RH. Detection of drug-dependent, platelet-reactive antibodies by antigen-capture ELISA and flow cytometry. Transfusion 1990;30:694-700 (Pubitemid 20361783)
42. Scognamiglio F, Corso C, Madeo D, et al. Flow cytometry in the diagnosis of drug-induced thrombocytopenia: two illustrative cases. Am J Hematol 2008;83:326-329
43. Bougie D, Johnson ST, Weitekamp LA, Aster RH. Sensitivity to a metabolite of diclofenac as a cause of acute immune hemolytic anemia. Blood 1997;90:407-413 (Pubitemid 27276586)
44. Linkins LA, Warkentin TE. The approach to heparin-induced thrombocytopenia. Semin Respir Crit Care Med 2008;29:66-74 • A recent review of the management of heparin-induced thrombocytopenia.
45. Unkle DW. Heparin-induced thrombocytopenia. Orthop Nurs 2007;26:383-387
46. Pourrat O. Treatment of drug-related diseases by plasma exchanges. Ann Med Interne 1994;145:357-360 (Pubitemid 24349886)
47. Drews RE. Critical issues in hematology: anemia, thrombocytopenia, coagulopathy, and blood product transfusions in critically ill patients. Clin Chest Med 2003;24:607-622 (Pubitemid 38028497)
48. Pedersen-Bjergaard U, Andersen M, Hansen PB. Drug-induced thrombocytopenia: clinical data on 309 cases and the effect of corticosteroid therapy. Eur J Clin Pharmacol 1997;52:183-189 (Pubitemid 27278372)
49. Mail on medical consulting agency. Available from: www.cremerconsulting. com