Hemolytic-uremic syndrome associated with gemcitabine: A case report and review of literature

Journal of the Pancreas

Volumn 6, Issue 4, 2005, Pages 369-374

  Saif, Muhammad Wasif ^a   McGee, Philip J ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

Anemia, hemolytic; Deoxycytidine; Hemolytic uremic syndrome; Kidney failure; Plasmapheresis; Thrombocytopenia

Indexed keywords

CORTICOSTEROID; ERYTHROPOIETIN; FLUOROURACIL; GEMCITABINE; LACTATE DEHYDROGENASE; LOPERAMIDE; MEGESTROL; PROCHLORPERAZINE; ANTINEOPLASTIC ANTIMETABOLITE; DEOXYCYTIDINE; DRUG DERIVATIVE;

AGED; ANEMIA; ARTICLE; BONE MARROW TOXICITY; CANCER RADIOTHERAPY; CASE REPORT; CLINICAL FEATURE; CORTICOSTEROID THERAPY; DIARRHEA; ENZYME DEFECT; HEMATURIA; HEMODIALYSIS; HEMOLYTIC UREMIC SYNDROME; HUMAN; HYPERBILIRUBINEMIA; KIDNEY BIOPSY; KIDNEY DYSFUNCTION; LABORATORY DIAGNOSIS; LACTATE DEHYDROGENASE BLOOD LEVEL; LEG EDEMA; LETHALITY; MALE; MEDICAL LITERATURE; PANCREAS ADENOCARCINOMA; PLASMAPHERESIS; PROTEINURIA; THROMBOCYTOPENIA; THROMBOTIC THROMBOCYTOPENIC PURPURA; CHEMICALLY INDUCED DISORDER; PANCREAS TUMOR; PATHOLOGY; REVIEW;

AGED; ANTIMETABOLITES, ANTINEOPLASTIC; DEOXYCYTIDINE; HEMOLYTIC-UREMIC SYNDROME; HUMANS; MALE; PANCREATIC NEOPLASMS;

EID: 27244450452     PISSN: 15908577     EISSN: 15908577     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Hollenbeck M, Kutkuhn B, Aul C, Leschke M, Willers R, Grabensee B. Haemolytic-uraemic syndrome and thrombotic-thrombocytopenic purpura in adults: clinical findings and prognostic factors for death and end-stage renal disease. Nephrol Dial Transplant 1998; 13:76-81.
2. Sens YA, Miorin LA, Silva HG, Malheiros DM, Filho DM, Jabur P. Acute renal failure due to hemolytic uremic syndrome in adult patients. Ren Fail 1997; 19:279-82.
3. Proesmans W. Typical and atypical hemolytic uremic syndrome. Kidney Blood Press Res 1996; 19:205-8.
4. Conlon PJ, Howell DN, Macik G, Kovalik EC, Smith SR. The renal manifestations and outcome of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in adults. Nephrol Dial Transplant 1995; 10:1189-93.
5. Melnyk AM, Solez K, Kjellstrand CM. Adult hemolytic-uremic syndrome. A review of 37 cases. Arch Intern Med 1995; 155:2077-84.
6. Remuzzi G, Ruggenenti P. The hemolytic uremic syndrome. Kidney Int 1995; 47:2-19.
7. Siegler R. The hemolytic uremic syndrome. Pediatr Clin North Am 1995; 42:1505-29.
8. Hrozencik SP, Connaughton MJ. Cancer-associated hemolytic uremic syndrome. Oncol Nurs Forum 1988; 15:755-9.
9. Hostetter AL, Tubbs RR, Ziegler T, Gephardt G, McMahon J, Schreiber MJ Jr. Chronic glomerular microangiopathy complicating metastatic carcinoma. Hum Pathol 1987; 18:342-8.
10. Seo DW, Lee YS, Chae JG, Lee MG, Choe GY, Chi HS, Min YI. Hepatocellular carcinoma associated hemolytic uremic syndrome unrelated to chemotherapy. J Korean Med Sci 1994; 9:254-8.
11. Milford DV, Goldstein A, Barrett M, Mann JR, Raafat F. Cancer associated haemolytic uraemic syndrome developing prior to treatment with cytotoxic agents. Med Pediatr Oncol 1993; 21:142-5.
12. Milutinovic J, Irby S, Fisher M. Hemolytic uremic syndrome and metastatic malignancy. South Med J 1982; 75:1409-11.
13. Anai H, Okada Y, Okubo K, Korenaga D, Maehara Y, Sugimachi K, Ohi Y. A case report of hemolytic uremic syndrome (HUS) induced by antineoplastic agents. Nippon Gan Chiryo Gakkai Shi 1990; 25:1487-91.
14. D'Elia JA, Aslani M, Schermer S, Cloud L, Bothe A, Dzik W. Hemolytic-uremic syndrome and acute renal failure in metastatic adenocarcinoma treated with mitomycin: case report and literature review. Ren Fail 1987; 10:107-13.
15. Crocker J, Jones E. Haemolytic-uraemic syndrome complicating long-term mitomycin C and 5-fluorouracil therapy for gastric carcinoma. J Clin Pathol 1983; 36:24-9.
16. Cantrell JE Jr, Phillips TM, Schein PS. Carcinoma-associated hemolytic-uremic syndrome: a complication of mitomycin C chemotherapy. J Clin Oncol 1985; 3:723-34.
17. Montes A, Powles TJ, O'Brien ME, Ashley SE, Luckit J, Treleaven J. A toxic interaction between mitomycin C and tamoxifen causing the haemolytic uraemic syndrome. Eur J Cancer 1993;29A:1854-7.
18. Hui YF, Reitz J. Gemcitabine: a cytidine analogue active against solid tumors. Am J Health-System Pharm 1997; 54:162-70.
19. Brodowicz T, Breiteneder S, Wiltschke C, Zielinski CC. Gemcitabine-induced hemolytic uremic syndrome: a case report. J Natl Cancer Inst 1997; 89:1895-6.
20. Sheldon R, Slaughter D. A syndrome of microangiopathic hemolytic anemia, renal impairment, and pulmonary edema in chemotherapy-treated patients with adenocarcinoma. Cancer 1986; 58:1428-36.
21. Fung MC, Storniolo AM, Nguyen B, Arning M, Brookfield W, Vigil J. A review of hemolytic uremic syndrome in patients treated with gemcitabine therapy. Cancer. 1999 May 1;85(9):2023-32.
22. Watson PR, Guthrie TH Jr, Caruana RJ. Cisplatin-associated hemolytic-uremic syndrome: successful treatment with a staphylococcal protein A column. Cancer 1989; 64:1400-3.
23. Antignac C, Gubler MC, Leverger G, Broyer M, Habib R. Delayed renal failure with extensive mesangiolysis following bone marrow transplantation. Kidney Int 1989; 35:1336-44.
24. Hillyer CD, Duncan A, Ledford M, Barrett TJ, Klumpp SA, Anderson DC, et al. Chemotherapy-induced hemolytic uremic syndrome: description of a potential animal model. J Med Primatol 1995; 24:68-73.
25. Monteagudo J, Pereira A, Roig S, Reverter JC, Ordinas A, Castillo R. Investigation of plasma von Willebrand factor and circulating platelet aggregating activity in mitomycin C-related hemolytic-uremic syndrome. Am J Hematol 1990; 33:46-9.
26. Mergenthaler HG, Binsack T, Wilmanns W. Carcinoma-associated hemolytic-uremic syndrome in a patient receiving 5-fluorouracil-adriamycin-mitomycin C combination chemotherapy. Oncology 1988; 45:11-4.
27. Gordon LI, Kwaan HC. Cancer and drug-associated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Semin Hematol 1997; 34:140-7.
28. Murgo AJ. Thrombotic microangiopathy in the cancer patient including those induced by chemotherapeutic agents. Semin Hematol 1987; 24:161-77.
29. van Setten PA, van Hinsbergh VW, van der Velden TJ, van de Kar NC, Vermeer M, Mahan JD, et al. Effects of TNF alpha on verocytotoxin cytotoxicity in purified human glomerular microvascular endothelial cells. Kidney Int 1997; 51:1245-56.
30. Zeigler ZR, Rosenfeld CS, Andrews DF 3rd, Nemunaitis J, Raymond JM, Shadduck RK, et al. Plasma von Willebrand factor antigen (vWF:AG) and thrombomodulin (TM) levels in adult thrombotic thrombocytopenic purpura/hemolytic uremic syndromes (TTP/HUS) and bone marrow transplant-associated thrombotic microangiopathy (BMT-TM). Am J Hematol 1996; 153:213-220.