Metastatic melanoma volume in sentinel nodes: Objective stereology-based measurement predicts disease recurrence and survival

Histopathology

Volumn 54, Issue 7, 2009, Pages 796-803

  Riber Hansen, Rikke ^c   Nyengaard, Jens R ^a   Hamilton Dutoit, Stephen J ^b   Sjoegren, Pia ^c   Steiniche, Torben ^d  

^a AARHUS UNIVERSITY   (Denmark)

^b Institute of Pathology   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d LILLEBAELT HOSPITAL   (Denmark)

Author keywords

Melanoma; Neoplasm metastasis; Pathology; Sentinel lymph node biopsy; Stereology; Tumour burden

Indexed keywords

ARTICLE; CANCER SURVIVAL; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MELANOMA METASTASIS; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; RECURRENT DISEASE; SENTINEL LYMPH NODE; STEREOLOGY; TUMOR VOLUME;

DENMARK; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MALE; MELANOMA; MIDDLE AGED; RECURRENCE; SENTINEL LYMPH NODE BIOPSY;

TOBACCO MOSAIC VIRUS;

EID: 66949147293     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2009.03312.x     Document Type: Article

References (27)

1. Morton DL, Thompson JF, Cochran AJ et al. Sentinel-node biopsy or nodal observation in melanoma. N. Engl. J. Med. 2006 355 1307 1317. (Pubitemid 44465459)
2. Gershenwald JE, Thompson W, Mansfield PF et al. Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients. J. Clin. Oncol. 1999 17 976 983. (Pubitemid 29109331)
3. Gutzmer R, Al GM, Geerlings H, Kapp A. Sentinel node biopsy in melanoma delays recurrence but does not change melanoma-related survival: a retrospective analysis of 673 patients. Br. J. Dermatol. 2005 153 1137 1141. (Pubitemid 41779567)
4. Anaya DA, Xing Y, Feng L et al. Adjuvant high-dose interferon for cutaneous melanoma is most beneficial for patients with early stage III disease. Cancer 2008 112 2030 2037. (Pubitemid 351574079)
5. Eggermont AM, Suciu S, Santinami M et al. Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial. Lancet 2008 372 117 126.
6. van Akkooi A, de Wilt JH, Verhoef C et al. Clinical relevance of melanoma micrometastases (<0.1 mm) in sentinel nodes: are these nodes to be considered negative? Ann. Oncol. 2006 17 1578 1585. (Pubitemid 44542045)
7. Starz H, Balda BR, Kramer KU, Buchels H, Wang H. A micromorphometry-based concept for routine classification of sentinel lymph node metastases and its clinical relevance for patients with melanoma. Cancer 2001 91 2110 2121. (Pubitemid 32476376)
8. Ranieri JM, Wagner JD, Azuaje R et al. Prognostic importance of lymph node tumor burden in melanoma patients staged by sentinel node biopsy. Ann. Surg. Oncol. 2002 9 975 981. (Pubitemid 35424631)
9. Govindarajan A, Ghazarian DM, McCready DR, Leong WL. Histological features of melanoma sentinel lymph node metastases associated with status of the completion lymphadenectomy and rate of subsequent relapse. Ann. Surg. Oncol. 2007 14 906 912. (Pubitemid 46175342)
10. Satzger I, Volker B, Al GM, Meier A, Kapp A, Gutzmer R. Prognostic significance of histopathological parameters in sentinel nodes of melanoma patients. Histopathology 2007 50 764 772. (Pubitemid 46683934)
11. Debarbieux S, Duru G, Dalle S, Beatrix O, Balme B, Thomas L. Sentinel lymph node biopsy in melanoma: a micromorphometric study relating to prognosis and completion lymph node dissection. Br. J. Dermatol. 2007 157 58 67. (Pubitemid 46934258)
12. Scheri RP, Essner R, Turner RR, Ye X, Morton DL. Isolated tumor cells in the sentinel node affect long-term prognosis of patients with melanoma. Ann. Surg. Oncol. 2007 14 2861 2866. (Pubitemid 47460638)
13. Pearlman NW, McCarter MD, Frank M et al. Size of sentinel node metastases predicts other nodal disease and survival in malignant melanoma. Am. J. Surg. 2006 192 878 881. (Pubitemid 44872996)
14. Rossi CR, De Salvo GL, Bonandini E et al. Factors predictive of nonsentinel lymph node involvement and clinical outcome in melanoma patients with metastatic sentinel lymph node. Ann. Surg. Oncol. 2008 15 1202 1210.
15. Dewar DJ, Newell B, Green MA, Topping AP, Powell BW, Cook MG. The microanatomic location of metastatic melanoma in sentinel lymph nodes predicts nonsentinel lymph node involvement. J. Clin. Oncol. 2004 22 3345 3349. (Pubitemid 41103692)
16. Cochran AJ, Wen DR, Morton DL. Occult tumor cells in the lymph nodes of patients with pathological stage I malignant melanoma. An immunohistological study. Am. J. Surg. Pathol. 1988 12 612 618. (Pubitemid 18193122)
17. Cserni G. Mapping metastases in sentinel lymph nodes of breast cancer. Am. J. Clin. Pathol. 2000 113 351 354. (Pubitemid 30217381)
18. Diaz LK, Hunt K, Ames F et al. Histologic localization of sentinel lymph node metastases in breast cancer. Am. J. Surg. Pathol. 2003 27 385 389. (Pubitemid 36245804)
19. Morton DL, Hoon DS, Cochran AJ et al. Lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: therapeutic utility and implications of nodal microanatomy and molecular staging for improving the accuracy of detection of nodal micrometastases. Ann. Surg. 2003 238 538 549.
20. Viehl CT, Guller U, Hamel CT et al. Carbon dye staining of sentinel lymph nodes facilitates microstaging of colon cancer patients. World J. Surg. 2006 30 453 456. (Pubitemid 43261372)
21. Riber-Hansen R, Nyengaard JR, Hamilton-Dutoit S, Steiniche T. Stage migration after minor changes in histological estimation of tumor burden in sentinel nodes: The protocol trap. Cancer 2009 115 2177 2187.
22. Gundersen HJ, Bendtsen TF, Korbo L et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 1988 96 379 394. (Pubitemid 18145920)
23. Gundersen HJ. The nucleator. J. Microsc. 1988 151 3 21.
24. Dorph-Petersen KA, Nyengaard JR, Gundersen HJ. Tissue shrinkage and unbiased stereological estimation of particle number and size. J. Microsc. 2001 204 232 246. (Pubitemid 34075121)
25. Bruel A, Christoffersen TE, Nyengaard JR. Growth hormone increases the proliferation of existing cardiac myocytes and the total number of cardiac myocytes in the rat heart. Cardiovasc. Res. 2007 76 400 408. (Pubitemid 350007452)
26. Riber-Hansen R, Sjoegren P, Hamilton-Dutoit SJ, Steiniche T. Extensive pathological analysis of selected melanoma sentinel lymph nodes: high metastasis detection rates at reduced workload. Ann. Surg. Oncol. 2008 15 1492 1501.
27. Singletary SE, Allred C, Ashley P et al. Revision of the American Joint Committee on Cancer staging system for breast cancer. J. Clin. Oncol. 2002 20 3628 3636. (Pubitemid 34983222)