The assessment of the antibacterial and antifungal activities of aspirin, EDTA and aspirin-EDTA combination and their effectiveness as antibiofilm agents

Journal of Applied Microbiology

Volumn 107, Issue 1, 2009, Pages 280-286

  Al Bakri, A G ^a   Othman, G ^a   Bustanji, Y ^a  

^a UNIVERSITY OF JORDAN   (Jordan)

Author keywords

Aspirin; Aspirin EDTA; Biofilm; EDTA; Nonantibiotics

Indexed keywords

ANTIFUNGAL AGENTS; CANDIDA; ESCHERICHIA COLI; MICROWAVE INTEGRATED CIRCUITS;

ABIOTIC SURFACES; ANTI-MICROBIAL ACTIVITY; ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY; ASPIRIN; ASPIRIN-EDTA; BACTERIAL BIOFILM; BIOFILM CULTURES; CONCENTRATION VALUES; MINIMAL INHIBITORY CONCENTRATION; NONANTIBIOTIC;

BIOFILMS;

ACETYLSALICYLIC ACID; EDETIC ACID;

ANTIBIOTICS; ANTIMICROBIAL ACTIVITY; ASSAY; ASSESSMENT METHOD; BACTERIUM; BIOFILM; CONCENTRATION (COMPOSITION); DRUG; EDTA; INHIBITION;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; BIOFILM; CANDIDA ALBICANS; COLONY FORMING UNIT; DRUG EFFICACY; DRUG POTENTIATION; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PLANKTON; PSEUDOMONAS AERUGINOSA;

BACTERIA (MICROORGANISMS); CANDIDA ALBICANS; ESCHERICHIA COLI; PSEUDOMONAS AERUGINOSA;

EID: 66849134951     PISSN: 13645072     EISSN: 13652672     Source Type: Journal    
DOI: 10.1111/j.1365-2672.2009.04205.x     Document Type: Article

References (29)

1. Alem, M. Douglas, J. (2004) Effects of aspirin and other nonsteroidal anti-inflammatory drugs on biofilms and planktonic cells of Candida albicans. Antimicrob Agents Chemother 48, 41 47. (Pubitemid 38040174)
2. Awtry, E. Loscalzo, J. (2000) Aspirin. Circulation 101, 1206 1218. (Pubitemid 30146625)
3. Banin, E., Brady, K. Greenberg, E. (2006) Chelator induced dispersal and killing of Pseudomonas aeruginosa cells in a biofilm. Appl Environ Microbiol 72, 2064 2069.
4. Cederlund, H. Mardh, P.A. (1993) Antibacterial activities of non-antibiotic drugs. J Antimicrob Chemother 32, 355 365.
5. Demirag, M.K., Esen, S., Zivalioglu, M., Leblebicioglu, H. Keceligil, H.T. (2007) The effect of aspirin on adherence of slime-producing coagulase-negative staphylococci to vascular grafts. Ann Vasc Surg 21, 464 467. (Pubitemid 47030838)
6. Donlan, R., Costerton, J., Raad, I., Hanna, H., Dvorak, T., Chaiban, G. Hachem, R. (2002) Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev 15, 167 193. (Pubitemid 34303762)
7. Gil, M.L., Casanova, M. Martínez, J.P. (1994) Changes in the cell wall glycoprotein composition of Candida albicans associated to the inhibition of germ tube formation by EDTA. Arch Microbiol 161, 489 494. (Pubitemid 24192015)
8. Gilbert, P., Allison, D.G. McBain, A.J. (2002) Biofilms in vitro and in vivo: do singular mechanisms imply cross-resistance? J Appl Microbiol 92, 98S 110S. (Pubitemid 34535512)
9. Harrison, J.J., Turner, R.J. Ceri, H. (2007) A subpopulation of Candida albicans and Candida tropicalis biofilm cells are highly tolerant to chelating agents. FEMS Microbiol Lett 272, 172 181. (Pubitemid 47074598)
10. Karabay, O., Arinc, H., Gunduz, H., Tamer, A., Ozhan, H. Uyan, C. (2006) A new effect of acetylsalicylic acid? Significantly lower prevalence of nasal carriage of Staphylococcus aureus among patients receiving orally administered acetylsalicylic acid. Infect Control Hosp Epidemiol 27, 318 319.
11. Kite, P., Eastwood, K., Sugden, S. Percival, S. (2004) Use of in vivo-generated biofilms from hemodialysis catheters to test the efficacy of a novel antimicrobial catheter lock for biofilm eradication in vitro. J Clin Microbiol 42, 3073 3076. (Pubitemid 38938060)
12. Mazur, I., Wurzer, W.J., Ehrhardt, C., Pleschka, S., Puthavathana, P., Silberzahn, T., Wolff, T., Planz, O. et al. (2007) Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaB-inhibiting activity. Cell Microbiol 9, 1683 1694. (Pubitemid 46958795)
13. Nicolau, D., Marangos, M., Nightingale, C. Quintiliani, R. (1995) Influence of aspirin on development and treatment of experimental Staphylococcus aureus endocarditis. Antimicrob Agents Chemother 39, 1748 1751.
14. Percival, S.L., Kite, P., Eastwood, K., Murga, R., Carr, J., Arduino, M.J. Donlan, R.M. (2005) Tetrasodium EDTA as a novel central venous catheter lock solution against biofilm. Infect Control Hosp Epidemiol 26, 511 514.
15. Price, C.T.D., Lee, I.R. Gustafson, J.E. (2000) The effects of salicylate on bacteria. Int J Biochem Cell Biol 32, 1029 1043.
16. Raad, I., Chatzinikolaou, I., Chaiban, G., Hanna, H., Hachem, R., Dvorak, T., Cook, W. Costerton, W. (2003) In vitro and ex vivo activities of minocycline and EDTA against microorganisms embedded in biofilm on catheter surfaces. Antimicrob Agents Chemother 47, 3580 3585. (Pubitemid 37345723)
17. Raad, I., Hanna, H., Dvorak, T., Chaiban, G. Hachem, R. (2007) Optimal antimicrobial catheter lock solution, using different combinations of minocycline, EDTA, and 25-percent ethanol, rapidly eradicates organisms embedded in biofilm. Antimicrob Agents Chemother 51, 78 83. (Pubitemid 46047690)
18. Ramage, G., Wickes, B. Lopez-Ribot, J. (2007) Inhibition on Candida albicans biofilm formation using divalent cation chelators (EDTA). Mycopathologia 164, 301 306. (Pubitemid 47622130)
19. Reardon, D.M., Warner, B. Trowbridge, E.A. (1991) EDTA, the traditional anticoagulant of haematology: with increased automation is it time for a review? Med Lab Sci 48, 72 75.
20. Root, J.L., McIntyre, O.R., Jacobs, N.J. Daghlian, C.P. (1988) Inhibitory effect of disodium EDTA upon the growth of Staphylococcus epidermidis in vitro: relation to infection prophylaxis of Hickman catheters. Antimicrob Agents Chemother 32, 1627 1631. (Pubitemid 18267605)
21. Sedlacek, M., Gemery, J.M., Cheung, A.L., Bayer, A.S. Remillard, B.D. (2007) Aspirin treatment is associated with a significantly decreased risk of Staphylococcus aureus bacteremia in hemodialysis patients with tunneled catheters. Am J Kidney Dis 49, 401 408. (Pubitemid 46320766)
22. Sherertz, R., Boger, M., Collins, C., Mason, L. Raad, I. (2006) Comparative in vitro efficacies of various catheter lock solutions. Antimicrob Agents Chemother 50, 1865 1868.
23. Stepanovic, S., Vukovic, D., Jesic, M. Ranin, L. (2004) Influence of acetylsalicylic acid (aspirin) on biofilm production by Candida species. J Chemother 16, 134 138. (Pubitemid 38756944)
24. Stewart, P. Costerton, J. (2001) Antibiotic resistance of bacteria in biofilms. Lancet 358, 135 138. (Pubitemid 32709857)
25. Taha, M.O., Al-Bakri, A.G. Zalloum, W.A. (2006) Discovery of potent inhibitors of pseudomonal quorum sensing via pharmacophore modeling and in silico screening. Bioorg Med Chem Lett 16, 5902 5906. (Pubitemid 44486725)
26. Vaara, M. (1992) Agents that increase the permeability of the outer membrane. Microbiol Rev 56, 395 411.
27. Wang, W., Wong, W., Dailidience, D., Berg, D., Gu, Q., Lai, K., Lam, S. Wong, B. (2003) Aspirin inhibits the growth of Helicobacter pylori and enhances its susceptibility to antimicrobial agents. Gut 52, 490 495. (Pubitemid 36363398)
28. White, R.L., Burgess, D.S., Manduru, M. Bosso, J.A. (1996) Comparison of three different in vitro methods of detecting synergy: time-kill, checkerboard, and E test. Antimicrob Agents Chemother 40, 1914 1918. (Pubitemid 26277815)
29. Yakandawala, N., Gawande, P.V., Lovetri, K. Madhyastha, S. (2007) Effect of ovotransferrin, protamine sulfate and EDTA combination on biofilm formation by catheter-associated bacteria. J Appl Microbiol 102, 722 727. (Pubitemid 46271211)