Branched-chain amino acid supplementation increases the lactate threshold during an incremental exercise test in trained individuals

Journal of Nutritional Science and Vitaminology

Volumn 55, Issue 1, 2009, Pages 52-58

  Matsumoto, Keitaro ^a   Koba, Takashige ^a   Hamada, Koichiro ^a   Tsujimoto, Hisaya ^b   Mitsuzono, Ryoichi ^b  

^a Otsuka Pharnlaceutical Co Ltd   (Japan)

^b KURUME UNIVERSITY   (Japan)

Author keywords

Branched chain amino acid; Endurance exercise capacity; Energy metabolism; Lactate threshold; Trained individuals

Indexed keywords

BRANCHED CHAIN AMINO ACID; LACTIC ACID; ARGINASE; CARBON DIOXIDE; OXYGEN;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BICYCLE ERGOMETER; CALORIC INTAKE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; ENDURANCE; EXERCISE; EXERCISE TEST; EXHAUSTION; HUMAN; HUMAN EXPERIMENT; INTESTINE ABSORPTION; LACTATE BLOOD LEVEL; LOADING TEST; LUNG GAS EXCHANGE; MALE; OXYGEN CONSUMPTION; WATER LOADING; WORKLOAD; BICYCLE; BLOOD; DRUG EFFECT; FITNESS; GLUCOSE BLOOD LEVEL; METABOLISM; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADULT; AMINO ACIDS, BRANCHED-CHAIN; ARGINASE; BICYCLING; BLOOD GLUCOSE; CARBON DIOXIDE; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; EXERCISE; EXERCISE TEST; HUMANS; LACTIC ACID; MALE; OXYGEN; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE; PHYSICAL FITNESS; YOUNG ADULT;

EID: 66849129138     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.55.52     Document Type: Article

References (29)

1. Harper AE. 1983. Some recent developments in the study of amino acid metabolism. Proc Nutr Soc 42: 437-449.
2. Harper AE, Miller RH, Block KP. 1984. Branched-chain amino acid metabolism. Annu Rev Nutr 4: 409-454.
3. Nair KS, Schwartz RG, Welle S. 1992. Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans. Am J Physiol 263: E928-E934.
4. Platell C, Kong SE, McCauley R, Hall JC. 2000. Branched-chain amino acids. J Gastroenterol Hepatol I 5: 706-717.
5. De Feo P, Di Loreto C, Lucidi P, Murdolo G, Parlanti N, De Cicco A, Piccioni F, Santensanio F. 2003. Metabolic response to exercise. J Endocrino1Invest 26: 851-854.
6. Dohm GL. 1986. Protein as a fuel for endurance exercise. Exer Sports Sci Rev 14: 143-173.
7. Rennie MJ. 1996. Influence of exercise on protein and amino acid metabolism. In: Exercise: Regulation and Integration of Multiple Systems (Rowell LB, Shepherd JT, eds), p 995-1035. American Physiological Society, Bethesda, MD.
8. Babij P, Matthews SM, Wolman SE, Halliday D, Millward DJ, Matthews DE, Rennie MJ. 1983. Blood ammonia and glutamine accumulation and leucine oxidation during exercise. In: Biochemistry of Exercise (Knuttgen HG, Vogel JA, Poortmans JR, eds), p 345-350. Human Kinetics, Champaign, IL.
9. Lamont LS, McCullough AJ, Kalhan SC. 2001. Relationship between leucine oxidation and oxygen consumption during steady state exercise. Med Sci Sports Exerc 33: 237-241.
10. Blomstrand E, Hassmen P, Ekblom B, Newsholme EA. 1991. Administration of branched-chain amino acids during sustained exercise-effects on performance and on plasma concentration of some amino acids. Eur J AppI Physiol 63: 83-88.
11. De Palo EF, Gatti R, Cappellin E, Schiraidi C, De Palo CB, Spinella P. 2001. Plasma lactate, GH and GH-binding protein levels in exercise following BCAA supplementation in athletes. Amino Acids 20: 1-11.
12. Wasserman K, Meilroy MB. 1964. Detecting the threshold of anaerobic metabolism in cardiac patients during exercise. Am J Cardiol 14: 844-852.
13. Yoshida T, Chida M, Ichioka M, Suda Y. 1987. Blood lactate parameters related to aerobic capacity and endurance performance. Eur J AppI Physiol 56: 7-11.
14. Beaver W, Wasserman K, Whipp BJ. 1985. Improved detection of lactate threshold during exercise using a log-log transformation. J Appl Physiol 59: 1936-1940.
15. MacLean DA, Graham TE, Saltin B. 1994. Branchedchain amino acids augment ammonia metabolism while attenuating protein breakdown during exercise. Am J Physiol 267: E1010-E1022.
16. Matsumoto K, Mizuno M, Mizuno T, Dilling-Hansen B, Lahoz A, Bertelsen V, Münster H, Jordening H, Hamada K, Doi T. 200 7. Branched-chain amino acids and arginine supplementation attenuates skeletal muscle proteolysis induced by moderate exercise in young individuals. Int J Sports Med 28: 531-538.
17. Shimomura Y, Murakami T, Nakai N, Nagasaki M, Obayashi M, Li Z, Xu M, Sato Y, Kato T, Shimomura N, Fujitsuka N, Tanaka K, Sato M. 2000. Suppression of glycogen consumption during acute exercise by dietary branched-chain amino acids in rats. J Nutr Sci Vitaminol 46: 71-77.
18. Soemitro S, Block KP, Crowell RL, Harper AE. 1989. Activities of branched-chain amino acid-degrading enzymes in liver from rats fed different dietary levels of protein. J Nutr 119: 1203-1212.
19. Mittleman KD, Ricci MR, Bailey SP. 1998. Branchedchain amino acids prolonged exercise during heat stress in men and women. Med Sci Sports Exerc 30: 83-91.
20. Madsen K, MacLean DA, Kiens B, Christensen D. 1996. Effects of glucose plus branched-chain amino acids, or placebo on bike performance over 100 km. J Appl Physiol 81: 2644-2650.
21. Pitkänen HT, Oja SS, Rusko H, Nummela A, Komi PV, Saransaari P, Takala T, Mero AA. 2003. Leucine supplementation does not enhance acute strength or running performance but affects serum amino acid concentration. Amino Acids 25: 85-94.
22. Watson P, Shirreffs SM, Maughan RJ. 2004. The effect of acute branched-chain amino acid supplementation on prolonged exercise capacity in a warm environment. Eur J Appl Physiol 93: 306-314.
23. Crowe MJ, Weatherson JN, Bowden BF. 2006. Effects of dietary leucine supplementation on exercise performance. Eur J Appl Physio 97: 664-672.
24. Isidori A, Monaco AL, Cappa M. 1981. A study of growth hormone release in man after oral administration of amino acids. Curr Med Res Opin 7: 475-481.
25. Layman DK. 2002. Role of leucine in protein metabolism during exercise and recovery. Can J Appl Physiol 27: 646-663.
26. MacLean DA, Graham TE, Saltin B. 1996. Stimulation of muscle ammonia production during exercise following branched-chain amino acid supplementation in humans. J Physiol 493: 909-922.
27. Koba T, Hamada K, Sakural M, Matsumoto K, Hayase H, Imaizumi K, Tsujimoto H, Mitsuzono R. 2007. Branched-chain amino acids supplementation attenuates the accumulation of blood lactate dehydrogenase during distance running. J Sports Med Phys Fitness 47: 316-322.
28. Skillen RA, Testa M, Applegate EA, Heiden EA, Fascetti AJ, Casazza GA. 2008. Effects of an amino acid-carbohydrate drink on exercise performance after consecutive-day exercise bouts. Int J Sports Nutr Exerc Metab 18: 473-492.
29. Jobgen WS, Fried SK, Fu WJ, Meininger CJ, Wu G. 2006. Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. J Nutr Biochem 17: 571-588.