cdr2, A target antigen of naturally occurring human tumor immunity, is widely expressed in gynecological tumors

Cancer Research

Volumn 60, Issue 8, 2000, Pages 2136-2139

  Darnell, Jennifer C ^a   Albert, Matthew L ^a   Darnell, Robert B ^a,b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b Box 226   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; BIOTINYLATION; BREAST CANCER; CANCER PATIENT; FEMALE GENITAL TRACT TUMOR; GENE EXPRESSION; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; OVARY CANCER; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR IMMUNITY; WESTERN BLOTTING;

ANTIGENS, NEOPLASM; BLOTTING, WESTERN; BREAST NEOPLASMS; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNE SERA; OVARIAN NEOPLASMS; PARANEOPLASTIC CEREBELLAR DEGENERATION; PURKINJE CELLS; UP-REGULATION;

EID: 0034655113     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Durnell, R. B., and DeAngelis, L. M. Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies. Lancet, 341: 21-22, 1993.
2. Darnell, R. B. Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity and the brain. Proc. Natl. Acad. Sci. USA, 93: 4529-4536, 1996.
3. Peterson, K., Rosenblum, M. K., Kotanides, H., and Posner, J. B. Paraneoplastic cerebellar degeneration. I. A clinical analysis of 55 anti-Yo antibody-positive patients. Neurology, 42: 1931-1937, 1992.
4. Fumeaux, H. M., Rosenblum, M. K., Dalmau, J., Wong, E., Woodruff, P., Graus, F., and Posner, J. B. Selective expression of Purkinje-cell antigens in tumor tissue from patients with paraneoplastic cerebellar degeneration. N. Engl. J. Med., 322: 1844-1851, 1990.
5. Corradi, J. P., Yang, C. W., Darnell, J. C., Dalmau, J., and Darnell, R. B. A post-transcriptional regulatory mechanism restricts expression of the paraneoplastic cerebellar degeneration antigen cdr2 to immune privileged tissues. J. Neurosci., 17: 1406-1415, 1997.
6. Albert, M. L., Austin, L. M., and Darnell, R. B. Detection and treatment of activated T cells in lhe cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration. Ann. Neurol., 47: 9-17, 2000.
7. Albert, M. L., Darnell, J. C., Bender, A., Francisco, L. M. Bhardwaj, N., and Darnell, R. B. Tumor-specific killer cells in paraneoplastic cerebellar degeneration. Nat. Med., 4: 1321-1324, 1998.
8. Boon, T., and Old, L. J. Cancer tumor antigens. Curr. Opin. Immunol., 9: 681-683, 1997.
9. O'Farrell, P. H. High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem., 250: 4007-4021, 1975.
10. Buckanovich, R. J., Posner, J. B., and Darnell, R. B. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. Neuron, 11: 657-672, 1993.
11. Okano, H. J., Park, W. Y., Corradi, J. P., and Darnel,. R. B. The cytoplasmic Purkinje antigen cdr2 downregulates Myc function: implications for neuronal and tumor cell survival. Genes Dev., 13: 2087-2098, 1999.
12. Graus, F., Dalmau, J., Rene, R., Tora, M., Malats, N., Verschuuren, J. J., Cardenal, F., Vinolas, N., Garcia del Muro, J., Vadell, C., Mason, W. P., Rosell, R., Posner, J. B., and Real, F. X. Anti-Hu antibodies in patients with small-cell lung cancer: association with complete response to therapy and improved survival. J. Clin. Oncol., 15: 2866-2872, 1997.
13. Dalmau, J., Furneaux, H. M., Gralla, R. J., Kris, M. G., and Posner, J. B. Detection of the anti-Hu antibody in the serum of patients with small cell lung cancer: a quantitative Western blot analysis. Ann. Neurol., 27: 544-552, 1990.
14. Dalmau, J., Furneaux, H. M., Cordon-Cardo, C., and Posner, J. B. The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues. Am. J. Pathol., 141: 881-886, 1992.
15. Dalmau, J., Graus, F., Cheung, N. V., Rosenblum, M. K., Ho, A., Cañete, A., Delattre, J., Thompson, S. J., and Posner, J. B. Major histocompatibility proteins, anti-Hu antibodies, and paraneoplastic encephalomyelitis in neuroblastoma and small cell lung cancer. Cancer (Phila.), 75: 99-109, 1995.
16. Schuler, G., and Steinman, R. M. Dendritic cells as adjuvants for immune-mediated resistance to tumors. J. Exp. Med., 186: 1183-1187, 1997.
17. Hahne, M., Rimoldi, D., Schroter, M. Romero, P., Schreier, M., French, L. E., Schneider, P., Bornand, T., Fontana, A., Lienard, D., Cerottini, J., and Tschopp, J. Melanoma cell expression of Fas(Apo-I/CD95) ligand: implications for tumor immune escape. Science (Washington DC), 274: 1363-1366, 1996.