Generation and characterization of the antibacterial activity of a novel hybrid antimicrobial peptide comprising functional domains from different insect cecropins

Canadian Journal of Microbiology

Volumn 55, Issue 5, 2009, Pages 520-528

  Plunkett, Richard M ^a,b   Murray, Stuart I ^a   Lowenberger, Carl A ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b NEW MEXICO HIGHLANDS UNIVERSITY   (United States)

Author keywords

Antimicrobial activity; Cecropin; Fusion expression; Hybrid antimicrobial peptides

Indexed keywords

AEDES AEGYPTI; ANTI-BACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIMICROBIAL COMPOUNDS; ANTIMICROBIAL PEPTIDE; CECROPIN; DROSOPHILA MELANOGASTER; EUKARYOTIC CELLS; FUNCTIONAL DOMAINS; FUNCTIONAL MOTIFS; FUSION EXPRESSION; GRAM-POSITIVE BACTERIUM; HYBRID ANTIMICROBIAL PEPTIDES; HYBRID MOLECULES; IMMUNE DEFENSE; MICROMOLAR CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; N-TERMINAL; PARENT MOLECULES; PROOF OF PRINCIPLES; SHEEP RED BLOOD CELLS;

AMINES; BACTERIA; BLOOD; CELLS; PEPTIDES; POLYPEPTIDES;

MOLECULES;

CECROPIN A; CECROPIN A1[27-40]; CECROPIN A[1-26]; CECROPIN A[1-26] CECROPIN A1[27-40] FUSION PROTEIN; HYBRID PROTEIN; POLYPEPTIDE ANTIBIOTIC AGENT; THIOREDOXIN; THIOREDOXIN CECROPIN A[1-26] CECROPIN A1[27-40] FUSION PROTEIN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; CONCENTRATION (COMPOSITION); FLY; HYBRID; INSECT; PEPTIDE;

AEDES AEGYPTI; ALCALIGENES FAECALIS; ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS COAGULANS; BACILLUS SUBTILIS; CARBOXY TERMINAL SEQUENCE; CITROBACTER FREUNDII; CONCENTRATION RESPONSE; DISK DIFFUSION; DROSOPHILA MELANOGASTER; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG PURIFICATION; DRUG SPECIFICITY; DRUG SYNTHESIS; ENTEROBACTER AEROGENES; ESCHERICHIA COLI; EUKARYOTIC CELL; HEMOLYSIS; HYBRIDIZATION; LACTOCOCCUS LACTIS; MICROCOCCUS LUTEUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; PSEUDOMONAS FLUORESCENS; SERRATIA MARCESCENS; SHEEP ERYTHROCYTE; STAPHYLOCOCCUS EPIDERMIDIS;

AEDES; AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CECROPINS; DROSOPHILA MELANOGASTER; ERYTHROCYTES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; SHEEP;

AEDES AEGYPTI; DROSOPHILA MELANOGASTER; EUKARYOTA; HEXAPODA; NEGIBACTERIA; OVIS ARIES; POSIBACTERIA;

EID: 66849115465     PISSN: 00084166     EISSN: None     Source Type: Journal    
DOI: 10.1139/W09-001     Document Type: Article

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