Fc fusion to Glucagon-like peptide-1 inhibits degradation by human DPP-IV, increasing its half-life in serum and inducing a potent activity for human GLP-1 receptor activation

BMB Reports

Volumn 42, Issue 4, 2009, Pages 212-216

  Kim, Dong Myung ^a,c   Chu, Seoung Ho ^a   Kim, Semi ^b   Park, Young Woo ^a   Kim, Sung Seob ^a  

^a LG Chemical Ltd   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Diabetes; Dipeptidyl peptidase IV; GLP 1 receptor; Glucagonlike peptide 1; IgG Fc

Indexed keywords

ORYCTOLAGUS CUNICULUS;

DIPEPTIDYL PEPTIDASE IV; DPP4 PROTEIN, HUMAN; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE RECEPTOR; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE RECEPTOR; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT;

ANIMAL; ARMYWORM; ARTICLE; BLOOD; CELL LINE; CHO CELL; CRICETULUS; GENETICS; HAMSTER; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE;

ANIMALS; ANTIGENS, CD26; BASE SEQUENCE; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; GLUCAGON-LIKE PEPTIDE 1; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; RECEPTORS, GLUCAGON; RECOMBINANT FUSION PROTEINS; SPODOPTERA;

EID: 66849101486     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2009.42.4.212     Document Type: Article

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