Clinical application of autofluorescence densitometry with a scanning laser ophthalmoscope

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 6, 2009, Pages 2994-3002

  Sekiryu, Tetsuju ^a   Iida, Tomohiro ^a   Maruko, Ichiro ^a   Horiguchi, Masayuki ^b  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; AUTOFLUORESCENCE DENSITOMETRY; BRANCH RETINAL ARTERY OCCLUSION; CHORIORETINOPATHY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DENSITOMETRY; FEMALE; HUMAN; LASER COAGULATION; LIGHT EXPOSURE; MALE; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA DETACHMENT; RETINA DISEASE; RETINA FOVEA; RETINA MACULA HOLE; SCANNING LASER OPHTHALMOSCOPE; CHORIORETINITIS; FLUORESCENCE; LASER; METABOLISM; MIDDLE AGED; OPHTHALMOSCOPE; PATHOPHYSIOLOGY; RETINA ARTERY OCCLUSION; RETINA TEAR; RETINA VEIN OCCLUSION;

DIAGNOSTIC AGENT; LIPOFUSCIN; VISUAL PIGMENT;

ADULT; AGED; CHORIORETINITIS; DENSITOMETRY; FEMALE; FLUORESCENCE; HUMANS; LASERS; LIPOFUSCIN; MALE; MIDDLE AGED; OPHTHALMOSCOPES; RETINAL ARTERY OCCLUSION; RETINAL DISEASES; RETINAL PERFORATIONS; RETINAL PIGMENTS; RETINAL VEIN OCCLUSION;

EID: 66849099177     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2774     Document Type: Article

References (44)

1. Vaclavik V, Vujosevic S, Dandekar SS, Bunce C, Peto T, Bird AC. Autofluorescence imaging in age-related macular degeneration complicated by choroidal neovascularization: a prospective study. Ophthalmology. 2008;115:342-346.
2. Smith RT, Chan JK, Busuoic M, Sivagnanavel V, Bird AC, Chong NV. Autofluorescence characteristics of early, atrophic, and high-risk fellow eyes in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2006;47:5495-5504.
3. Schmitz-Valckenberg S, Bultmann S, Dreyhaupt J, Bindewald A, Holz FG, Rohrschneider K. Fundus autofluorescence and fundus perimetry in the junctional zone of geographic atrophy in patients with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2004;45:4470-4476.
4. Holz FG, Bindewald-Wittich A, Fleckenstein M, Dreyhaupt J, Scholl HP, Schmitz-Valckenberg S. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. Am J Ophthalmol. 2007;143:463-472.
5. Delori FC, Dorey CK, Staurenghi G, Arend O, Goger DG, Weiter JJ. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci. 1995;36:718-729.
6. Eldred GE, Katz ML. Fluorophores of the human retinal pigment epithelium: separation and spectral characterization. Exp Eye Res. 1988;47:71-86.
7. Framme C, Roider J. Fundus autofluorescence in macular hole surgery. Ophthalmic Surg Lasers. 2001;32:383-390.
8. Sayanagi K, Ikuno Y, Tano Y. Different fundus autofluorescence patterns of retinoschisis and macular hole retinal detachment in high myopia. Am J Ophthalmol. 2007;144:299-301.
9. Alpern M, Pugh EN Jr. The density and photosensitivity of human rhodopsin in the living retina. J Physiol. 1974;237:341-370.
10. Rushton WA, Campbell FW. Measurement of rhodopsin in the living human eye. Nature. 1954;174:1096-1097.
11. van Norren D, van der Kraats J. A continuously recording retinal densitometer. Vision Res. 1981;21:897-905.
12. Liem AT, Keunen JE, van Norren D, van de Kraats J. Rod densitometry in the aging human eye. Invest Ophthalmol Vis Sci. 1991;32:2676-2682.
13. Tornow RP, Stilling R, Zrenner E. Scanning laser densitometry and color perimetry demonstrate reduced photopigment density and sensitivity in two patients with retinal degeneration. Vision Res. 1999;39:3630-3641.
14. Kemp CM, Faulkner DJ. Rhodopsin measurement in human disease: fundus reflectometry using television. Dev Ophthalmol. 1981;2:130-134.
15. Elsner AE, Burns SA, Beausencourt E, Weiter JJ. Foveal cone photopigment distribution: small alterations associated with macular pigment distribution. Invest Ophthalmol Vis Sci. 1998;39:2394-2404.
16. Hood C, Rushton WA. The Florida retinal densitometer. J Physiol. 1971;217:213-229.
17. Prieto PM, McLellan JS, Burns SA. Investigating the light absorption in a single pass through the photoreceptor layer by means of the lipofuscin fluorescence. Vision Res. 2005;45:1957-1965.
18. van Norren D, van de Kraats J. Imaging retinal densitometry with a confocal scanning laser ophthalmoscope. Vision Res. 1989;29: 1825-1830.
19. Spaide RF. Fundus autofluorescence and age-related macular degeneration. Ophthalmology. 2003;110:392-399.
20. Scholl HP, Chong NH, Robson AG, Holder GE, Moore AT, Bird AC. Fundus autofluorescence in patients with Leber congenital amaurosis. Invest Ophthalmol Vis Sci. 2004;45:2747-2752.
21. Theelen T, Berendschot TT, Boon CJ, Hoyng CB, Klevering BJ. Analysis of visual pigment by fundus autofluorescence. Exp Eye Res. 2008;86:296-304.
22. Alpern M. Rhodopsin kinetics in the human eye. J Physiol. 1971; 217:447-471.
23. Rushton WA, Baker HD. Effect of a very bright flash on cone vision and cone pigments in man. Nature. 1963;200:421-423.
24. Wustemeyer H, Moessner A, Jahn C, Wolf S. Macular pigment density in healthy subjects quantified with a modified confocal scanning laser ophthalmoscope. Graefes Arch Clin Exp Ophthalmol. 2003;241:647-651.
25. Delori FC, Goger DG, Dorey CK. Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Invest Ophthalmol Vis Sci. 2001;42:1855-1866.
26. Curcio CA, Sloan KR, Kalina RE, Hendrickson AE. Human photoreceptor topography. J Comp Neurol. 1990;292:497-523.
27. Wihlmark U, Wrigstad A, Roberg K, Brunk UT, Nilsson SE. Lipofuscin formation in cultured retinal pigment epithelial cells exposed to photoreceptor outer segment material under different oxygen concentrations. APMIS. 1996;104:265-271.
28. Haralampus-Grynaviski NM, Lamb LE, Clancy CM, et al. Spectroscopic and morphological studies of human retinal lipofuscin granules. Proc Natl Acad Sci USA. 2003;100:3179-3184.
29. Rozanowska M, Pawlak A, Rozanowski B, et al. Age-related changes in the photoreactivity of retinal lipofuscin granules: role of chloroform-insoluble components. Invest Ophthalmol Vis Sci. 2004;45:1052-1060.
30. Katz ML, Gao CL. Vitamin A incorporation into lipofuscin-like inclusions in the retinal pigment epithelium. Mech Ageing Dev. 1995;84:29-38.
31. Framme C, Brinkmann R, Birngruber R, Roider J. Autofluorescence imaging after selective RPE laser treatment in macular diseases and clinical outcome: a pilot study. Br J Ophthalmol. 2002;86:1099-1106.
32. Stitt AW, Gardiner TA, Archer DB. Retinal and choroidal responses to panretinal photocoagulation: an ultrastructural perspective. Graefes Arch Clin Exp Ophthalmol. 1995;233:699-705.
33. Kondo M, Miyake Y, Horiguchi M, Suzuki S, Tanikawa A. Clinical evaluation of multifocal electroretinogram. Invest Ophthalmol Vis Sci. 1995;36:2146-2150.
34. Karacorlu M, Ozdemir H, Arf Karacorlu S. Optical coherence tomography findings in branch retinal artery occlusion. Eur J Ophthalmol. 2006;16:352-353.
35. Moschos M, Brouzas D, Koutsandrea C, Stefanos B, Loukianou H, Papantonis F. Assessment of central serous chorioretinopathy by optical coherence tomography and multifocal electroretinography. Ophthalmologica. 2007;221:292-298.
36. Suzuki K, Hasegawa S, Usui T, et al. Multifocal electroretinogram in patients with central serous chorioretinopathy. Jpn J Ophthalmol. 2002;46:308-314.
37. Ojima Y, Tsujikawa A, Hangai M, et al. Retinal sensitivity measured with the micro perimeter 1 after resolution of central serous chorioretinopathy. Am J Ophthalmol. 2008;146:77-84.
38. Ojima Y, Hangai M, Sasahara M, et al. Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography. Ophthalmology. 2007;114:2197-2207.
39. Chuang EL, Sharp DM, Fitzke FW, Kemp CM, Holden AL, Bird AC. Retinal dysfunction in central serous retinopathy. Eye. 1987;1(1): 120-125.
40. Chappelow AV, Marmor MF. Multifocal electroretinogram abnormalities persist following resolution of central serous chorioretinopathy. Arch Ophthalmol. 2000;118:1211-1215.
41. Koizumi H, Spaide RF, Fisher YL, Freund KB, Klancnik JM Jr, Yannuzzi LA. Three-dimensional evaluation of vitreomacular traction and epiretinal membrane using spectral-domain optical coherence tomography. Am J Ophthalmol. 2008;145:509-517.
42. Sakamoto A, Hangai M, Yoshimura N. Spectral-domain optical coherence tomography with multiple B-scan averaging for enhanced imaging of retinal diseases. Ophthalmology. 2008;115: 1071-1078.e7.
43. Srinivasan VJ, Ko TH, Wojtkowski M, et al. Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci. 2006;47:5522-5528.
44. Wojtkowski M, Srinivasan V, Fujimoto JG, et al. Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography. Ophthalmology. 2005;112:1734-1746.