Autofluorescence imaging of NADH and flavoproteins in the rat brain: Insights from Monte Carlo simulations

Optics Express

Volumn 17, Issue 12, 2009, Pages 9477-9490

  L’heureux, Barbara ^a   Gurden, Hirac ^a   Pain, Frédéric ^a  

^a Centre National de la Recherche Scientifique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; INTELLIGENT SYSTEMS; ODORS; RATS;

AUTOFLUORESCENCE IMAGING; CELLULAR SIGNALS; FUNCTIONAL IMAGING; HEMODYNAMIC CHANGES; INTRINSIC OPTICAL IMAGING; PHYSIOLOGICAL FEATURES; SOMATOSENSORY CORTEX; TEMPORAL PROFILE;

MONTE CARLO METHODS;

FLAVOPROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BRAIN MAPPING; COMPUTER SIMULATION; CYTOLOGY; FLUORESCENCE MICROSCOPY; METABOLISM; METHODOLOGY; MONTE CARLO METHOD; RAT; SOMATOSENSORY CORTEX; SPECTROFLUOROMETRY;

ANIMALS; BRAIN MAPPING; COMPUTER SIMULATION; FLAVOPROTEINS; MICROSCOPY, FLUORESCENCE; MODELS, NEUROLOGICAL; MONTE CARLO METHOD; NAD; RATS; SOMATOSENSORY CORTEX; SPECTROMETRY, FLUORESCENCE;

EID: 66849097830     PISSN: None     EISSN: 10944087     Source Type: Journal    
DOI: 10.1364/OE.17.009477     Document Type: Article

References (45)

1. T. Bonhoeffer and Grinvald A, “Optical Imaging based on intrinsic signals: the methodology” in Brain mapping; the methods”. A.W. Toga and J.C. Mazziotta, Eds. (Academic Press, Los Angeles, CA, 1996).
2. B. Chance, P. Cohen, F. Jöbsis, B. Schoener, “Intracellular oxidation-reduction states in vivo,” Science 137, 499-508 (1962).
3. B. Chance, “The kinetics of flavoprotein and pyridine nucleotide oxidation in cardiac mitochondria in the presence of calcium,” FEBS Lett. 26, 315-9 (1972).
4. M. Hashimoto, Y. Takeda, T. Sato, H. Kawahara, O. Nagano and M. Hirakawa, “Dynamic changes of NADH fluorescence images and NADH content during spreading depression in the cerebral cortex of gerbils,” Brain. Res. 872, 294-300 (2000).
5. R.E. Anderson and F.B. Meyer, “In vivo fluorescent imaging of NADH redox state in brain,” Methods Enzymol. 352, 482-94 (2002).
6. A. Mayevsky and G.G. Rogatsky, “Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies,” Am. J. Physiol. Cell. Physiol. 292, C615-40 (2007).
7. K.C. Reinert, R.L. Dunbar, W. Gao, G. Chen, T.J. Ebner, “Flavoprotein autofluorescence imaging of neuronal activation in the cerebellar cortex in vivo,” J. Neurophysiol. 92,199-211 (2004).
8. K. Shibuki, R. Hishida, H. Murakami, M. Kudoh, T. Kawaguchi, M. Watanabe, S. Watanabe, T. Kouuchi, R. Tanaka., “Dynamic imaging of somatosensory cortical activity in the rat visualized by flavoprotein autofluorescence,” J. Physiol. 549, 919-27 (2003).
9. H. Murakami, D. Kamatani, R. Hishida, T. Takao, M. Kudoh, T. Kawaguchi, R. Tanaka, K.Shibuki, “Short-term plasticity visualized with flavoprotein autofluorescence in the somatosensory cortex of anaesthetized rats,” Eur. J. Neurosci. 19, 1352-60 (2004).
10. M. Tohmi, H. Kitaura, S. Komagata, M. Kudoh, K. Shibuki, “Enduring critical period plasticity visualized by transcranial flavoprotein imaging in mouse primary visual cortex,” J. Neurosci. 26, 11775-85 (2006).
11. Y. Kubota, D. Kamatani, H. Tsukano, S. Ohshima, K. Takahashi, R. Hishida, M. Kudoh, S. Takahashi, K. Shibuki, “Transcranial photo-inactivation of neural activities in the mouse auditory cortex,” Neurosci. Res. 60, 422-30 (2008).
12. K.C. Reinert, W. Gao, G. Chen, T.J. Ebner, “Flavoprotein autofluorescence imaging in the cerebellar cortex in vivo,” J. Neurosci. Res. 85, 3221-32 (2007).
13. B. Weber, C. Burger, M.T. Wyss, G.K. von Schulthess, F. Scheffold, A. Buck, “Optical imaging of the spatiotemporal dynamics of cerebral blood flow and oxidative metabolism in the rat barrel cortex,” Eur. J. Neurosci. 20, 2664-70 (2004).
14. H. Gurden, N. Uchida, et Z.F. Mainen, “Sensory-evoked intrinsic optical signals in the olfactory bulb are coupled to glutamate release and uptake,” Neuron 52, 335-45 (2006).
15. G.C. Petzold, D.F. Albeanu, T.F. Sato, V.N. Murthy, “Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways,” Neuron 58, 897-910 (2008).
16. C.W. Shuttleworth, A.M. Brennan, et J.A. Connor, “NAD(P)H fluorescence imaging of postsynaptic neuronal activation in murine hippocampal slices,” J Neurosci. 23, 3196-208 (2003).
17. S. A. Prahl, “Optical Absorption of Hemoglobin,” http://omlc.osi.edu/spectra/hemoslobin/index.html
18. C.C.H. Petersen, “The barrel cortex--integrating molecular, cellular and systems physiology,” Pflugers Arch. 447, 126-34 (2003).
19. T.A. Woolsey, C.M. Rovainen, S.B. Cox, M.H. Henegar, G.E. Liang, D. Liu, Y.E. Moskalenko, J. Sui, L. Wei, “Neuronal units linked to microvascular modules in cerebral cortex: response elements for imaging the brain,” Cereb. Cortex. 6, 647-60 (1991).
20. G.M. Shepherd, “Synaptic organization of the mammalian olfactory bulb,” Physiol. Rev. 52, 864-917 (1972).
21. E. Chaigneau, M. Oheim, E. Audinat, S. Charpak, “Two-photon imaging of capillary blood flow in olfactory bulb glomeruli,” Proc. Natl. Acad. Sci. U. S. A. l00, 13081-6 (2003).
22. M. Kohl, U. Lindauer, G. Royl, M. Kuhl, L. Gold, A. Villringer, U. Dirnagl., “Physical model for the spectroscopic analysis of cortical intrinsic optical signals,” Phys. Med. Biol. 45, 3749-64 (2000).
23. N. Plesnila, C. Putz, M. Rinecker, J. Wiezorrek, L. Schleinkofer, A.E. Goetz, W.M. Kuebler, “Measurement of absolute values of hemoglobin oxygenation in the brain of small rodents by near infrared reflection spectrophotometry,” J. Neurosci. Methods 114, 107-17 (2002).
24. J.C. Nawroth, C.A. Greer, W.R. Chen, S.B. Laughlin, G.M. Shepherd, “An energy budget for the olfactory glomerulus,” J. Neurosci. 27, 9790-800 (2007).
25. A.N. Yaroslavsky, P.C. Schulze, I.V. Yaroslavsky, R. Schober, F. Ulrich, H.J. Schwarzmaier, “Optical properties of selected native and coagulated human brain tissues in vitro in the visible and near infrared spectral range,” Phys. Med. Biol. 47, 2059-73 (2002).
26. E.M. Hillman, A. Devor, M.B. Bouchard, A.K. Dunn, G.W. Krauss, J. Skoch, B.J. Bacskai, A.M. Dale, D.A. Boas, “Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation,” Neuroimage 35, 89-104 (2007).
27. M. Jones, J. Berwick, et J. Mayhew, “Changes in blood flow, oxygenation, and volume following extended stimulation of rodent barrel cortex,” Neuroimage 15, 474-87 (2002).
28. J. Mayhew, Y. Zheng, Y. Hou, B. Vuksanovic, J. Berwick, S. Askew, P. Coffey, “Spectroscopic analysis of changes in remitted illumination: the response to increased neural activity in brain,” Neuroimage 10, 304-26 (1999).
29. A. Devor, A. K. Dunn, M. L. Andermann, I. Ulbert, D. A. Boas, A. M. Dale1 “Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex,” Neuron 39, 353-9 (2003).
30. S. A. Prahl, M. Keijzer, S. L. Jacques, A. J. Welch, “A Monte Carlo Model of Light Propagation in Tissue,” Proc. SPIE IS 5, 102-11(1989).
31. L. Wang, S.L. Jacques, et L. Zheng, “MCML-Monte Carlo modeling of light transport in multilayered tissues,” Comput. Methods Programs Biomed. 47, 131-46 (1995).
32. F. Agner, “Pseudo random number generator;” http://www.agner.org/random/mother.
33. B. Chance, B. Schoener, R. Oshino, F. Itshak, Y. Nakase, “Oxidation-reduction ratio studies of mitochondria in freeze-trapped samples. NADH and flavoprotein fluorescence signals,” J. Biol. Chem. 254, 4764-71 (1979).
34. R.C. Benson, R.A. Meyer, M.E. Zaruba, G.M. McKhann, “Cellular autofluorescence--is it due to flavins?,” J. Histochem. Cytochem. 27, 44-8 (1979).
35. A.M. Brennan, J.A. Connor, et C.W. Shuttleworth, “Modulation of the amplitude of NAD(P)H fluorescence transients after synaptic stimulation,” J. Neurosci. Res. 85, 3233-43 (2007).
36. A.M. Brennan, J.A. Connor, et C.W. Shuttleworth, “NAD(P)H fluorescence transients after synaptic activity in brain slices: predominant role of mitochondrial function,” J. Cereb. Blood Flow. Metab. 26, 1389-406 (2006).
37. T.R. Husson, A.K. Mallik, J.X. Zhang, N.P. Issa, “Functional imaging of primary visual cortex using flavoprotein autofluorescence,” J. Neurosci. 27, 8665-75 (2007).
38. R. Scholz, R.G. Thurman, J.R. Williamson, B. Chance, T. Bücher., “Flavin and pyridine nucleotide oxidation-reduction changes in perfused rat liver. I. Anoxia and subcellular localization of fluorescent flavoproteins,” J. Biol. Chem. 244, 2317-24 (1969).
39. F.F. Jöbsis, M. O'Connor, A. Vitale, H. Vreman, “Intracellular redox changes in functioning cerebral cortex. I. Metabolic effects of epileptiform activity,” J. Neurophysiol. 34, 735-49 (1971).
40. F. Xu, I. Kida, F. Hyder, R.G. Shulman, “Assessment and discrimination of odor stimuli in rat olfactory bulb by dynamic functional MRI,” Proc Natl Acad Sci U S A. 97, 10601-6. (2000).
41. B.A. Johnson, M. Leon, “Spatial distribution of [14C]2-deoxyglucose uptake in the glomerular layer of the rat olfactory bulb following early odor reference learning,” J Comp Neurol. 37, 6557-66. (1996)
42. O. Wolfbeis, “Fluorescence of organic natural products,” in Molecular Luminescence Spectroscopy. Part 1: Methods and Applications, John Wiley and Sons, ed. (S. G. Schulman, 1985), pp. 167-370.
43. A. Grinvald, E. Lieke, R.D. Frostig, C.D. Gilbert, T.N. Wiesel, “Functional architecture of cortex revealed by optical imaging of intrinsic signals,” Nature 324, 361-4 (1986).
44. M. Jones, J. Berwick, J. Mayhew, “Changes in blood flow, oxygenation, and volume following extended stimulation of rodent barrel cortex,” Neuroimage 15, 474-87 (2002).
45. Prakash, J. D., Biag, S. A., Sheth, S. Mitsuyama, J. Theriot, C. Ramachandra, A.W. Toga, “Temporal profiles and 2-dimensional oxy-, deoxy-, and total-hemoglobin somatosensory maps in rat versus mouse cortex,” Neuroimage 37 Suppl 1, S27-36 (2007).