Synthesis, characterization and enzyme activity assays of peptides nitriles as inhibitors of cathepsin K

Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities

Volumn 30, Issue 4, 2009, Pages 716-719

  Li, Hong Wei ^a   Liu, Xin Chen ^a   Yang, Jin Gang ^b   Jiang, Kun ^b   Fang, Xue Xun ^b   Wu, Yu Qing ^a  

^a State Key Laboratory of Supramolecular Structure and Material   (China)

^b JILIN UNIVERSITY   (China)

Author keywords

Cathepsin K; Inhibitor; Peptide nitrile; Structure activity relationship

Indexed keywords

EID: 66849091418     PISSN: 02510790     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Lecaille F., Kaleta J., Brömme D.. Chem. Rev.[J]. 2002, 102: 4459-4488
2. Otto H. H., Schirmeister T.. Chem. Rev.[J]. 1997, 97: 133-171
3. Falgueyret J. P., Oballa R. M., Okamoto O., et al. J. Med. Chem.[J]. 2001, 44: 94-104
4. Liu Hai-Dong, Xiao Jun-Hai, Li Song. Letters in Biotechnology[J]. 2006, 17: 119-122
5. Wu Yan, Wang Yi, Yang Gang-Yi. Chinese Journal of Osteoporosis[J]. 2006, 12: 522-524
6. Löser R., Schilling K., Dimming E., et al. J. Med. Chem.[J]. 2005, 48: 7688-7707
7. Palmer J. T., Bryant C., Wang D. X., et al. J. Med. Chem.[J]. 2005, 48: 7520-7534
8. Ma L. J., Liu Y. F., Wu Y. Q.. Chem. Commun.[J]. 2006, 25: 2702-2704
9. Wang Hua, Zhao Mi-Feng, Li Gang, et al. Chem. J. Chinese Universities[J]. 2006, 27(2): 240-243
10. Wang Ding, Zhang Qi-Han, Xu Jia-Xi. Chem. J. Chinese Universities[J]. 2006, 27(4): 669-671
11. Falgueyret J. P., Black W. C., Cromlish W., et al. Anal. Biochem.[J]. 2004, 335: 218-227
12. Robichaud J., Bayly C., Oballa R., et al. Bioorg. Med. Chem. Lett.[J]. 2004, 14: 4291-4295
13. Setti E. L., Venkatraman S., Palmer J. T., et al. Bioorg. Med. Chem. Lett.[J]. 2006, 16: 4296-4299