Simultaneous quantification of seven major bufadienolides in three traditional Chinese medicinal preparations of ChanSu by HPLC-DAD

Natural Product Communications

Volumn 4, Issue 2, 2009, Pages 179-184

  Ma, Xiao Chi ^a   Zhang, Bao Jing ^a   Xin, Xiu Lan ^b   Huang, Shan Shan ^a   Deng, Sha ^a   Zhang, Hou Li ^a   Shu, Xiao Hong ^a   Diao, Yun Peng ^a   Cui, Jian ^c  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b Beijing Vocational College of Electronic Science and Technology   (China)

^c Center University for Nationalities   (China)

Author keywords

Bufadienolides; ChanSu; RP HPLC; Traditional chinese medicinal preparations

Indexed keywords

ACETIC ACID; ACETONITRILE; BUFADIENOLIDE DERIVATIVE; BUFALIN; BUFOGENIN; BUFOTALIN; CHANSU; CHINESE DRUG; CINOBUFAGIN; CINOBUFOTALIN; GAMABUFOTALIN; TELOCINOBUFAGIN; UNCLASSIFIED DRUG; HERBACEOUS AGENT;

AQUEOUS SOLUTION; ARTICLE; CALIBRATION; CHINESE MEDICINE; DRUG DETERMINATION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; QUANTITATIVE ANALYSIS; CHAN SU; CHEMICAL STRUCTURE; CHEMISTRY; METHODOLOGY;

BUFANOLIDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; MEDICINE, CHINESE TRADITIONAL; MOLECULAR STRUCTURE;

EID: 66849085893     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0900400203     Document Type: Article

References (16)

1. National Commission of Chinese Pharmacopoeia. (2005) Pharmacopoeia of the People's Republic of China. Chemical Industry Press, Beijing, 2, 316.
2. Krenn L, Kopp B. (1998) Bufadienolides from animal and plant sources. Phytochemistry, 48, 1-4.
3. Steyn PS, Van Heerden FR. (1998) Bufadienolides of plant and animal origin. Natural Product Reports, 15, 397-403.
4. Hashimoto S, Jing Y, Kawazoe N. (1997) Bufalin reduces the level of topoisomerase II in human leukemia cells and affects the cytotoxicity of anticancer drugs. Leukemia Research, 21, 875-883. (Pubitemid 27488715)
5. Watabo M., Masuda Y, Nakajo S. (1996) The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells. Journal of Biological Chemistry, 271, 14067-14073. (Pubitemid 26190300)
6. Efferth T, Davey M, Olbrich A. (2002) Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug- resistant human CCRF-CEM leukemia cells. Blood Cells Molecular Diseases, 28, 160-168. (Pubitemid 34743750)
7. Yeh JY, Huang WJ, Kan SF, Wang PS. (2003) Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells. Prostate, 54, 112-117.
8. Masuda Y, Kawazoe N, Nakajo S. (1995) Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia-cells. Leukemia Research, 19, 549-556.
9. Kamano Y, Kotake A, Hashima H. (1998) Structure-cytotoxic activity relationship for the toad poison bufadienolides. Bioorganic & Medicinal Chemistry, 6, 1504-1507.
10. Kamano Y, Yamashita A, Nogawa T. (2002) QSAR evaluation of the Chan Su and related bufadienolides against the colchicineresistant primary liver carcinoma cell line PLC/PRF/51. Journal of Medicinal Chemistry, 45, 5440-5447.
11. +-ATPase receptor. Journal of Medicinal Chemistry, 40, 3484-3488.
12. th ed. Macmillan: New York, 716-717.
13. th ed. Charles C. Tomas: Spring field, IL, 562-564.
14. Ye M, Guo H, Guo HZ, Han J, Guo DA. (2006) Simultaneous determination of cytotoxic bufadienolides in the Chinese medicine ChanSu by high-performance liquid chromatography coupled with photodiode array and mass spectrometry detections. Journal of Chromatography B, 838, 86-95.
15. Ye M, Guo DA. (2005) Analysis of bufadienolides in the Chinese drug ChanSu by high-performance liquid chroamtography/diode array detection/ atmospheric pressure chemical ionization-tandem mass spectrometry. Rapid Communication in Mass Spectrometry, 19, 1881-1982.
16. Song H, Guo T, Bi K, Wang H, Zhang R. (2000) Determination of resibufogenin and cinobufagin in heart-protecting musk pill by HPLC. Biomedicine Chromatography, 14, 130-134.