Reversal of experimental varicocele-induced testicular toxicity by L-ascorbate in rats

African Journal of Biotechnology

Volumn 8, Issue 6, 2009, Pages 965-970

  Saalu, L C ^a   Oguntola, J A ^a   Babalola, O S ^a   Oyewopo, A O ^b  

^a LAGOS STATE UNIVERSITY   (Nigeria)

^b UNIVERSITY OF ILORIN   (Nigeria)

Author keywords

Ascorbic acid; Infertility; Testis; Varicocele

Indexed keywords

ASCORBIC ACID; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DECAPITATION; HISTOPATHOLOGY; HORMONE BLOOD LEVEL; MALE; NONHUMAN; RAT; SPERMATIC VEIN; SPERMATOZOON; VARICOCELE; VEIN LIGATION; WEIGHT CHANGE;

ANIMALIA; RATTUS;

EID: 66749186584     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Bjelakovic G (2007). Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297(8): 842-857.
2. Hendin BN, Kolettis PN, Sharma RK, Thomas A (1999). Varicocele is associated with elevated spermatozoal reactive oxygen species production and diminished seminal plasma antioxidant capacity. J. Urol. 161: 1831-1834.
3. Henry MP, Howard SS, Turner TT (1986). Repair of experimental varicoceles in rats. Long-term effects on testicular blood flow and temperature and Caudaepididymal sperm concentration and motility. J. Androl. 7: 271-276.
4. Hudson RW (1988). The endocrinology of varicocele. Fertil. Steril. 49:199-208.
5. Kass EJ, Stork BR, Steinert BW (2001). Varicocele in adolescence induces left and right testicular volume loss. BJU Int. 87: 499-501.
6. Lewis SE, Boyle PM, McKinney KA, Young IS, Thompson W (1995). Total infertile men. Fertil Steril. 64: 865.
7. McCluskey SE (1985). Which Vertebrates Make Vitamin C? (PDF). Origins 12(2): 96-100.
8. Ozdama RAS, Soylu ALT, Culha M, Ozden M, Gokal PA (2004). Testicular Oxidative stress. Effects of experimental varicocele in adolescent rats. Urol. Int. 73: 3437.
9. Ozokutan BH, Kucukaydin M, Muhtaroglu S, Tekin Y (2000). The role of nitricoxide in testicular ischemia-reperfusion injury. J. Pediatr. Surg; 35: 101-103.
10. Padayatty S, Katz A, Wang Y, Eck P, Kwon O, Lee J, Chen S, Corpe C, Dutta A, Dutta S, Levine M (2003). Vitamin C as an antioxidant: evaluation of its role in disease prevention" (PDF). J. Am. Coll. Nutr. 22(1): 18-35. PMID 12569111.
11. Saalu LC, Togun VA, Oyewopo AO, Raji Y (2006). Artificial crypptor- chidism and the moderating effect of melatonin in Sprague-Dawley rats. J. Appl. Sci. 6(14): 2889-2894.
12. Saalu LC, Oluyemi KA, Omotuyi IO (2007). a-Tocopherol (vitamin E) attenuates the testicular toxicity associated with experimental cryptorchidism in rats. Afr. J. Biotechnol. 6(12): 1373-1377.
13. Santoro G, Romeo C, Impellizzeri P, Cutroneo G, Trimarchi F (2001). Nitricoxide synthase patterns in normal and varicocele testis in adolescents. BJU Int; 88: 967-973.
14. Saypol DC, Howards SS, Turner TT, Miller ED (1981). Influence of Surgically induced Varicocele on testicular Blood flow, temperature and histology in adult rats and dogs. J. Clin. Invest. 68: 39-45.
15. Semercioz A, Onor RO (2003). Effect of melatonin on testicular tissue nitricoxide level and antioxidant enzyme activities in experimentally induced left varicocele. Neuroendocrinol. Lett. Nos Vfc Feb-Apr. 24:45-50.
16. Sharma RK, Agarwal A (1996). Role of reactive oxygen species in male fertility. Urology 48: 835-838.
17. Sofikitis N, Miyagawa I (1992). Experimental models for the study of varicocele: A selected review. Jpn. J. Fertil. Steril. 38: 168-177.
18. Suziki N, Sofikitis N (1999). Protective effects of antioxidants on testicular fractions of varicocelized rats. Yonago Acta. Med, 42: 87-94.
19. World Health Organization (WHO) (1992). The influence of varicocele on parameters of fertility in a large group of men presenting to infertility clinics. Fertil Steril; 57: 1289-1293.