First chemoenzymatic synthesis of immunomodulating macrolactam pimecrolimus

Tetrahedron Letters

Volumn 50, Issue 30, 2009, Pages 4384-4388

  Ferraboschi, Patrizia ^a   Colombo, Diego ^a   De Mieri, Maria ^a   Grisenti, Paride ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b Poli Industria Chimica SpA   (Italy)

Author keywords

Ascomycin; Immunomodulator; Lipase; Macrolactam; Regioselectivity

Indexed keywords

HYDROXYL GROUP; PIMECROLIMUS; TRIACYLGLYCEROL LIPASE;

ALCOHOLYSIS; ARTICLE; CANDIDA ANTARCTICA; CATALYST; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SYNTHESIS; HYDROLYSIS; IMMUNOMODULATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

CANDIDA ANTARCTICA;

EID: 66749138208     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.05.066     Document Type: Article

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29. +; pimecrolimus (exact mass 809.4) spectrum shows the main peak at 832.4 m/z.
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