C32-amino derivatives of the immunosuppressant ascomycin

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 17, 1997, Pages 2199-2204

  Ok, Hyun O ^a   Szumiloski, John L ^a   Beattie, Thomas R ^a   Goulet, Mark T ^a   Staruch, Mary Jo ^a   Dumont, Francis J ^a   Wyvratt, Matthew J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCOMYCIN; IMMUNOSUPPRESSIVE AGENT;

ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE; X RAY CRYSTALLOGRAPHY;

EID: 0030931957     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00409-5     Document Type: Article

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22. 50 = 1.4 nM) activity relative to ascomycin in a T-cell proliferation assay.