Alterations of epinephrine-induced gluconeogenesis in aging

Experimental and Molecular Medicine

Volumn 41, Issue 5, 2009, Pages 334-340

  Kim, Kyungtae ^a,b   Sung, Chun Cho ^a   Cova, Anthony ^a   Ik, Soon Jang ^c   Sang, Chul Park ^a  

^a Seoul National University   (South Korea)

^b National Cancer Center   (South Korea)

^c Korea Basic Science Institute (KBSI)   (South Korea)

Author keywords

Aging; Epinephrine; G protein coupled receptor kinases; Glucagon; Gluconeogenesis; Hepatocytes

Indexed keywords

ADRENALIN; BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 3; GLUCAGON; GLUCOSE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

AGED; ANIMAL CELL; ARTICLE; CELL AGING; CONTROLLED STUDY; GLUCONEOGENESIS; GROUPS BY AGE; HORMONE ACTION; LIVER CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

RATTUS;

EID: 66749132400     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2009.41.5.037     Document Type: Article

References (30)

1. Benovic JL, Onorato JJ, Arriza JL, Stone WC, Lohse M, Jenkins NA, Gilbert DJ, Copeland NG, Caron MG, Lefkowitz RJ. Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family. J Biol Chem 1991;266:14939-14946 (Pubitemid 21907600)
2. Burgess SC, Hausler N, Merritt M, Jeffrey FM, Storey C, Milde A, Koshy S, Lindner J, Magnuson MA, Malloy CR, Sherry AD. Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem 2004;279:48941-48949 (Pubitemid 39625775)
3. Dax EM, Partilla JS, Gregerman RI. Mechanism of the age-related decrease of epinephrine-stimulated lipolysis in isolated rat adipocytes: beta-adrenergic receptor binding, adenylate cyclase activity, and cyclic AMP accumulation. J Lipid Res 1981;22:934-943 (Pubitemid 11029357)
4. Dax EM, Partilla JS, Pineyro MA, and Gregerman RI. Beta-adrenergic receptors, glucagon receptors, and their relationship to adenylate cyclase in rat liver during aging. Endocrinology 1987;120:1534-1541 (Pubitemid 17054011)
5. Dobson JG Jr, Fray J, Leonard JL, Pratt RE. Molecular mechanisms of reduced beta-adrenergic signaling in the aged heart as revealed by genomic profiling. Physiol Genomics 2003;15:142-147 (Pubitemid 38089560)
6. Eakes AT, Hymer TK, Rosenthal MJ, Moss J, Katz MS. Alterations of adenylyl cyclase-linked G proteins in rat liver during aging. Am J Physiol Endocrinol Metab 1996;270:E126-32 (Pubitemid 26059343)
7. Erraji-Benchekroun L, Couton D, Postic C, Borde I, Gaston J, Guillet JG, and Andre C. Overexpression of beta2- adrenergic receptors in mouse liver alters the expression of gluconeogenic and glycolytic enzymes. Am J Physiol Endocrinol Metab 2005;288:E715-22 (Pubitemid 40397206)
8. Fraeyman N, Van ermen A. Influence of aging on the beta- and glucagon-receptor-mediated glycogenolysis in rat hepatocytes. Mech Ageing Dev 1993;70:115-126
9. Fraeyman N, Van de velde E, Van ermen A, Bazan A, Vanderheyden P, Van emmelo J, and Vandekerckhove J. Effect of maturation and aging on [beta]-adrenergic signal transduction in rat kidney and liver. Biochemical Pharmacology 2000;60:1787-1795
10. Goodman OB Jr, Krupnick JG, Santini F, Gurevich VV, Penn RB, Gagnon AW, Keen JH, Benovic JL. Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature 1996;383:447-450 (Pubitemid 26330835)
11. Hanson RW, Reshef L. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu Rev Biochem 1997;66:581-611 (Pubitemid 27274668)
12. Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 2001;413:179-183 (Pubitemid 32867880)
13. Jelinek LJ, Lok S, Rosenberg GB, Smith RA, Grant FJ, Biggs S, Bensch PA, Kuijper JL, Sheppard PO, Sprecher CA, Et A. Expression cloning and signaling properties of the rat glucagon receptor. Science 1993;259:1614-1616 (Pubitemid 23114641)
14. Liu JS, Park EA, Gurney AL, Roesler WJ, Hanson RW. Cyclic AMP induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription is mediated by multiple promoter elements. J Biol Chem 1991;266:19095-19102 (Pubitemid 21908197)
15. Mabry TR, Gold PE, Mccarty R. Age-related changes in plasma catecholamine responses to acute swim stress. Neurobiol Learn Mem 1995;63:260-268
16. Marker JC, Clutter WE, Cryer PE. Reduced epinephrine clearance and glycemic sensitivity to epinephrine in older individuals. Am J Physiol 1998;275:E770-6 (Pubitemid 28536315)
17. Morgan NG, Blackmore PF, Exton JH. Age-related changes in the control of hepatic cyclic AMP levels by alpha 1- and beta 2-adrenergic receptors in male rats. J Biol Chem 1983;258:5103-5109
18. Parruti G, Ambrosini G, Sallese M, and De blasi A. Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2. Biochem Biophys Res Commun 1993;190:475-481
19. Pierce KL, Premont RT, Lefkowitz RJ. Seven-transmembrane receptors. Nat Rev Mol Cell Biol 2002;3: 639-650 (Pubitemid 34987785)
20. Pilkis SJ, Claus TH, Johnson RA, Park CR. Hormonal control of cyclic 3′:5′-AMP levels and gluconeogenesis in isolated hepatocytes from fed rats. J Biol Chem 1975;250:6328-6336
21. Podolin DA, Gleeson TT, Mazzeo RS. Hormonal regulation of hepatic gluconeogenesis: influence of age and training. Am J Physiol Regul Integr Comp Physiol 1996;270: R365-72 (Pubitemid 126756297)
22. Podolin DA, Wills BK, Wood IO, Lopez M, Mazzeo RS, Roth DA. Attenuation of age-related declines in glucagon-mediated signal transduction in rat liver by exercise training. Am J Physiol Endocrinol Metab 2001;281:E516-23 (Pubitemid 32880925)
23. Schutzer WE, Reed JF, Bliziotes M, Mader SL. Upregulation of G protein-linked receptor kinases with advancing age in rat aorta. Am J Physiol Regul Integr Comp Physiol 2001;280:R897-903 (Pubitemid 32494096)
24. Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol 1976;13:29-83
25. Short JM, Wynshaw-Boris A, Short HP, Hanson RW. Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains. J Biol Chem 1986;261:9721-9726 (Pubitemid 17214099)
26. Sumida KD, Arimoto SM, Catanzaro MJ, Frisch F. Effect of age and endurance training on the capacity for epinephrine-stimulated gluconeogenesis in rat hepatocytes. J Appl Physiol 2003;95:712-719 (Pubitemid 36944296)
27. Tobias ES, Rozengurt E, Connell JM, Houslay MD. Cotransfection with protein kinase D confers phorbol-ester-mediated inhibition on glucagon-stimulated cAMP accumulation in COS cells transfected to overexpress glucagon receptors. Biochem J 1997;326(Pt 2):545-551 (Pubitemid 27417235)
28. Valera A, Pujol A, Pelegrin M, Bosch F. Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 1994;91:9151-9154
29. Wynshaw-Boris A, Short J, Loose D, Hanson R. Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. I. Multiple hormone regulatory elements and the effects of enhancers. J Biol Chem 1986;261:9714-9720
30. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 2001;413:131-138 (Pubitemid 32867868)