New developments in serodiagnosis of childhood celiac disease: Assay of antibodies against deamidated gliadin

Annals of the New York Academy of Sciences

Volumn 1173, Issue , 2009, Pages 28-35

  Prause, Christian ^a   Richter, Thomas ^b   Koletzko, Sibylle ^c   Uhlig, H Holm ^a   Hauer, Almuthe C ^d   Stern, Martin ^e   Zimmer, Klaus Peter ^f   Laass, Martin W ^g   Probst, Christian ^h   Schlumberger, Wolfgang ^h   Mothes, Thomas ^a  

^a UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^b Municipal Children's Hospital Sankt Georg   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d ST ANNA CHILDREN S HOSPITAL   (Austria)

^e UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^f UNIVERSITY HOSPITAL GIESSEN   (Germany)

^g UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^h Institute of Experimental Immunology   (Germany)

Author keywords

Accuracy; Celiac disease; Deamidated gliadin; Diagnosis; Tissue transglutaminase

Indexed keywords

GLIADIN ANALOGOUS FUSION PEPTIDE; GLIADIN ANTIBODY; GLUTEN; HYBRID PROTEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; CELIAC DISEASE; CHILDHOOD DISEASE; CONFERENCE PAPER; DEAMINATION; DIAGNOSTIC ACCURACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLLOW UP; GLUTEN FREE DIET; HUMAN; IMMUNOASSAY; IMMUNOGLOBULIN A DEFICIENCY; INTERMETHOD COMPARISON; SENSITIVITY AND SPECIFICITY; SERODIAGNOSIS;

EID: 66749099266     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04638.x     Document Type: Conference Paper

References (26)

1. Dieterich, W., T. Ehnis, M. Bauer, et al. 1997. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat. Med. 3: 797-801.
2. Fasano, A. 2003. Celiac disease-how to handle a clinical chameleon. N. Engl. J. Med. 348: 2568-2570.
3. Marsh, M.N. 1992. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 102: 330-354.
4. Oberhuber, G., G. Granditsch & H. Vogelsang. 1999. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur. J. Gastroenterol. Hepatol. 11: 1185-1194.
5. Bürgin-Wolff, A., H. Gaze, F. Hadziselimovic, et al. 1991. Antigliadin and antiendomysium antibody determination for coeliac disease. Arch. Dis. Child 66: 941-947.
6. Ghedira, I., R. Sghiri, A. Ayadi, et al. 2001. Anti-endomysium, anti-reticulin and anti-gliadin antibodies, value in the diagnosis of celiac disease in the child. Pathol. Biol. (Paris) 49: 47-52.
7. Simell, S., A. Kupila, S., Hoppu, S., et al. 2005. Natural history of transglutaminase autoantibodies and mucosal changes in children carrying HLA-conferred celiac disease susceptibility. Scand. J. G a s-troenterol. 40: 1182-1191.
8. McGowan, K.E., M.E. Lyon & J.D. Butzner. 2008. Celiac disease and IgA deficiency: complications of serological testing approaches encountered in the clinic. Clin. Chem. 54: 1203-1209.
9. Osman, A.A., T. Günnel, A. Dietl, et al. 2000. B cell epitopes of gliadin. Clin. Exp. Immunol. 121: 248-254.
10. Mothes, T. 2007. Deamidated gliadin peptides as targets for celiac disease-specific antibodies. Adv. Clin. Chem. 44: 35-63.
11. Schwertz, E., F. Kahlenberg, U. Sack, et al. 2004. Serologic assay based on gliadin-related nonapep-tides as a highly sensitive and specific diagnostic aid in celiac disease. Clin. Chem. 50: 2370-2375.
12. Prince, H.E. 2006. Evaluation of the INOVA diagnostics enzyme-linked immunosorbent assay kits for measuring serum immunoglobulin G (IgG) and IgA to deamidated gliadin peptides. Clin. Vaccine Immunol. 13: 150-151.
13. Sugai, E., H. Vazquez, F. Nachman, et al. 2006. Accuracy of testing for antibodies to synthetic gliadin-related peptides in celiac disease. Clin. Gastroenterol. Hepatol. 4: 1112-1117.
14. Niveloni, S., S. Sugai, A. Cabanne, et al. 2007. Antibodies against synthetic deamidated gliadin peptides as predictors of celiac disease: Prospective assessment in an adult population with a high pretest probability of disease. Clin. Chem. 53: 2186-2192.
15. Prause, C., M. Ritter, C. Probst, et al. Antibodies against deamidated gliadin as new and accurate biomarkers of childhood coeliac disease. J. P e d . Gastroenterol. Nutr. [in press].
16. Agardh, D. 2007. Antibodies against synthetic deami-dated gliadin peptides and tissue transglutaminase for the identification of childhood celiac disease. Clin. Gastroenterol. Hepatol. 5: 1276-1281.
17. Liu, E., M. Li, L. Emery, et al. 2007. Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac disease. J. Pediatr. Gastroenterol. Nutr. 45: 293-300.
18. Basso, D., G. Guariso, P. Fogar, et al. 2009. Antibodies against synthetic deamidated gliadin peptides for celiac disease diagnosis and follow-up in children. Clin. Chem. [Epub ahead of print].
19. Lagerqvist, C., I. Dahlbom, T. Hansson, et al. 2008. Antigliadin immunoglobulin A best in finding celiac disease in children younger than 18 months of age. J. Pediatr. Gastroenterol. Nutr. 47: 428-435.
20. Volta, U., A. Granito, E. Fiorini, et al. 2008. Usefulness of antibodies to deamidated gliadin peptides in celiac disease diagnosis and follow-up. Dig. Dis. Sci. 53: 1582-1588.
21. Kaukinen, K., P. Collin & M. Mäki. 2007. Latent coeliac disease or coeliac disease beyond villous atrophy? Gut 56: 1339-1340.
22. Green, P.H.R. & C. Cellier. 2007. Celiac disease. N. Engl. J. Med. 357: 1731-1743.
23. Villalta, D., M.G. Alessio, M. Tampoia, et al. 2007. Testing for IgG class antibodies in celiac disease patients with selective IgA deficiency. A comparison of the diagnostic accuracy of 9 IgG anti-tissue transglutaminase, 1 IgG anti-gliadin and 1 IgG anti-deaminated gliadin peptide antibody assays. Clin. Chim. Acta 382: 95-99.
24. Briani C., D. Samaroo & A. Alaedini. 2008. Celiac disease: from gluten to autoimmunity. Autoimmun. Rev. 7: 644-650.
25. Setty, M., L. Hormaza & S. Guandalini. 2008. Celiac disease. Risk assessment, diagnosis, and monitoring. Mol. Diag. Ther. 12: 289-298.
26. Hill, P.G. & G.K.T. Holmes. 2008. Coeliac disease: a biopsy is not always necessary for diagnosis. Aliment. Pharmacol. Ther. 27: 572-577.