IgE-mediated chlorhexidine allergy: A new occupational hazard?

Occupational Medicine

Volumn 59, Issue 4, 2009, Pages 270-272

  Nagendran, Vasantha ^a   Wicking, Jennifer ^b   Ekbote, Anjali ^a   Onyekwe, Theresa ^b   Garvey, Lene Heise ^c  

^a EPSOM AND ST HELIER UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^b QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^c Rigshospitalet   (Denmark)

Author keywords

Chlorhexidine; Occupational allergy; Type I hypersensitivity

Indexed keywords

CHLORHEXIDINE; IMMUNOGLOBULIN E;

ADULT; ALLERGY TEST; ARTICLE; AWARENESS; CASE REPORT; FEMALE; GENERAL HOSPITAL; HEALTH CARE PERSONNEL; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MALE; OCCUPATIONAL ALLERGY; OCCUPATIONAL HAZARD; OPERATING ROOM; PATIENT IDENTIFICATION; PRICK TEST; PRIORITY JOURNAL; QUESTIONNAIRE; UNITED KINGDOM;

ADULT; ANTI-INFECTIVE AGENTS, LOCAL; CHLORHEXIDINE; DERMATITIS, OCCUPATIONAL; FEMALE; GREAT BRITAIN; HANDWASHING; HEALTH PERSONNEL; HOSPITALS, DISTRICT; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; INFECTION CONTROL; MALE; MIDDLE AGED; QUESTIONNAIRES; SKIN TESTS;

EID: 66749089222     PISSN: 09627480     EISSN: 14718405     Source Type: Journal    
DOI: 10.1093/occmed/kqp042     Document Type: Article

References (11)

1. NHS National Patient Safety Agency 'Clean Your Hands Campaign'. http://www.npsa.nhs.uk/cleanyourhands. (6 March 2009, date last accessed).
2. Pratt RJ, Pellowe CM, Wilson JA et al. epic2: National evidence-based guidelines for preventing healthcare-associated infections in NHS hospitals in England. J Hosp Infect 2007;65S S1-S64.
3. Ownby DR. A history of latex allergy. J Allergy Clin Immunol 2002;110(2 Suppl.):S27-S32.
4. Ebo DG, Bridts CH, Stevens WJ. IgE-mediated anaphylaxis from chlorhexidine: Diagnostic possibilities. Contact Derm 2006;55 301-302.
5. Garvey LH, Kroigaard M, Poulsen LK et al. IgE-mediated allergy to chlorhexidine. J Allergy Clin Immunol 2007;120: 409-415.
6. Brydon MJ. Skin Prick Testing in Clinical Practice. The Cornerstone of Allergy Diagnosis. Norwich, Norfolk: NADAAS, 2000; 38-39.
7. Sato K, Kusaka Y, Suganuma N, Nagasawa S, Deguchi Y. Occupational allergy in medical doctors. J Occup Health 2004;46:165-170.
8. Garvey LH, Roed-Petersen J, Husum B. Is there a risk of sensitization and allergy to chlorhexidine in health care workers? Acta Anaesthesiol Scand 2003;47:720-724.
9. Wong WK, Goh CL, Chan KW. Contact urticaria from chlorhexidine. Contact Dermatitis 1990;22:52.
10. Garvey LH, Roed-Petersen J, Husum B. Anaphylactic reactions in anaesthetised patients - four cases of chlorhexidine allergy. Acta Anaesthesiol Scand 2001;45:1290-1294.
11. Stephens R, Mythen M, Kallis P, Davies DW, Egner W, Rickards A. Two episodes of life-threatening anaphylaxis in the same patient to a chlorhexidine-sulphadiazine-coated central venous catheter. Br J Anaesth 2001;87:306-308.