Identification of a pleiotropic locus on chromosome 7q for a composite left ventricular wall thickness factor and body mass index: The HyperGEN Study

BMC Medical Genetics

Volumn 10, Issue , 2009, Pages

  Tang, Weihong ^a   Devereux, Richard B ^b   Li, Na ^c   Oberman, Albert ^d   Kitzman, Dalane W ^e   Rao, Dabeeru C ^f   Hopkins, Paul N ^g   Claas, Steven A ^h   Arnett, Donna K ^h  

^a UNIVERSITY OF MINNESOTA   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d University of Alabama at Birmingham   (United States)

^e WAKE FOREST SCHOOL OF MEDICINE   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF UTAH   (United States)

^h UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AFRICAN AMERICAN; ARTICLE; BODY HEIGHT; BODY MASS; BODY SIZE; CAUCASIAN; CHROMOSOME 7Q; DOPPLER ECHOCARDIOGRAPHY; FACTORIAL ANALYSIS; FEMALE; GENE IDENTIFICATION; GENETIC LINKAGE; GENETIC VARIABILITY; HEART LEFT VENTRICLE FILLING; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE MASS; HEART LEFT VENTRICLE WALL; HEART RATE; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEART VENTRICLE SEPTUM; HEART VENTRICLE SIZE; HERITABILITY; HUMAN; LINKAGE ANALYSIS; MALE; MICROSATELLITE MARKER; PLEIOTROPY; CHROMOSOME 7; ECHOGRAPHY; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HEART LEFT VENTRICLE HYPERTROPHY; HEART VENTRICLE; HYPERTENSION; MIDDLE AGED; ORGAN SIZE;

ADULT; AFRICAN AMERICANS; BODY MASS INDEX; CHROMOSOMES, HUMAN, PAIR 7; ECHOCARDIOGRAPHY, DOPPLER; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEART VENTRICLES; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; LOD SCORE; MALE; MIDDLE AGED; ORGAN SIZE;

EID: 66649107020     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-10-40     Document Type: Article

References (36)

1. Levy D Garrison RJ Savage DD Kannel WB Castelli WP Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study N Engl J Med 1990, 322(22):1561-1566 2139921
2. Savage DD Levy D Dannenberg AL Garrison RJ Castelli WP Association of echocardiographic left ventricular mass with body size, blood pressure and physical activity (the Framingham Study) Am J Cardiol 1990, 65(5):371-376 10.1016/0002-9149(90)90304-J 2137280
3. Burke GL Arcilla RA Culpepper WS Webber LS Chiang YK Berenson GS Blood pressure and echocardiographic measures in children: The Bogalusa Heart Study Circulation 1987, 75(1):106-114 2947739
4. de Simone G Devereux RB Kimball TR Mureddu GF Roman MJ Contaldo F Daniels SR Interaction between body size and cardiac workload: Influence on left ventricular mass during body growth and adulthood Hypertension 1998, 31(5):1077-1082 9576117
5. Voutilainen S Kupari M Hippelainen M Karppinen K Ventila M Heikkila J Factors influencing Doppler indexes of left ventricular filling in healthy persons Am J Cardiol 1991, 68(6):653-659 10.1016/ 0002-9149(91)90360-W 1877483
6. Palmieri V Bella JN DeQuattro V Roman MJ Hahn RT Dahlof B Sharpe N Lau CP Chen WC Paran E et al Relations of diastolic left ventricular filling to systolic chamber and myocardial contractility in hypertensive patients with left ventricular hypertrophy (The PRESERVE Study) Am J Cardiol 1999, 84(5):558-562 10.1016/S0002-9149(99)00377-X 10482155
7. Fox ER Taylor J Taylor H Han H Samdarshi T Arnett D Myerson M Left ventricular geometric patterns in the Jackson cohort of the Atherosclerotic Risk in Communities (ARIC) Study: Clinical correlates and influences on systolic and diastolic dysfunction Am Heart J 2007, 153(2):238-244 10.1016/j.ahj.2006.09.013 17239683
8. Tang W Arnett DK Devereux RB Province MA Atwood LD Oberman A Hopkins PN Kitzman DW Sibling resemblance for left ventricular structure, contractility, and diastolic filling Hypertension 2002, 40(3):233-238 10.1161/01.HYP.0000028487.62501.12 12215459
9. Verhaaren HA Schieken RM Mosteller M Hewitt JK Eaves LJ Nance WE Bivariate genetic analysis of left ventricular mass and weight in pubertal twins (the Medical College of Virginia twin study) Am J Cardiol 1991, 68(6):661-668 10.1016/0002-9149(91)90361-N 1877484
10. Bella JN MacCluer JW Roman MJ Almasy L North KE Best LG Lee ET Fabsitz RR Howard BV Devereux RB Heritability of left ventricular dimensions and mass in American Indians: The Strong Heart Study J Hypertens 2004, 22(2):281-286 10.1097/00004872-200402000-00011 15076185
11. Tang W Miller MB Rich SS North KE Pankow JS Borecki IB Myers RH Hopkins PN Leppert M Arnett DK Linkage analysis of a composite factor for the multiple metabolic syndrome: The National Heart, Lung, and Blood Institute Family Heart Study Diabetes 2003, 52(11):2840-2847 10.2337/ diabetes.52.11.2840 14578304
12. Williams RR Rao DC Ellison RC Arnett DK Heiss G Oberman A Eckfeldt JH Leppert MF Province MA Mockrin SC et al NHLBI family blood pressure program: Methodology and recruitment in the HyperGEN network. Hypertension genetic epidemiology network Ann Epidemiol 2000, 10(6):389-400 10.1016/S1047-2797(00)00063-6 10964005
13. Devereux RB Roman MJ Evaluation of cardiac function and vascular structure and function by echocardiography and other noninvasive techniques Hypertension: Pathophysiology, diagnosis, and management New York: Raven P Laragh JH, Brenner BM 1995:1969-1985
14. Sahn DJ DeMaria A Kisslo J Weyman A Recommendations regarding quantitation in M-mode echocardiography: Results of a survey of echocardiographic measurements Circulation 1978, 58(6):1072-1083 709763
15. Schiller NB Shah PM Crawford M DeMaria A Devereux R Feigenbaum H Gutgesell H Reichek N Sahn D Schnittger I et al Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms J Am Soc Echocardiogr 1989, 2(5):358-367 2698218
16. Devereux RB Alonso DR Lutas EM Gottlieb GJ Campo E Sachs I Reichek N Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings Am J Cardiol 1986, 57(6):450-458 10.1016/ 0002-9149(86)90771-X 2936235
17. Palmieri V Dahlof B DeQuattro V Sharpe N Bella JN de Simone G Paranicas M Fishman D Devereux RB Reliability of echocardiographic assessment of left ventricular structure and function: The PRESERVE study. Prospective Randomized Study Evaluating Regression of Ventricular Enlargement J Am Coll Cardiol 1999, 34(5):1625-1632 10.1016/S0735-1097(99)00396-4 10551715
18. Hinds D Risch N The ASPEX package: Affected sib-pair exclusion mapping [computer program] Stanford: Stanford U 1996 http://aspex.sourceforge.net/
19. Almasy L Blangero J Multipoint quantitative-trait linkage analysis in general pedigrees Am J Hum Genet 1998, 62(5):1198-1211 1377101 9545414 10.1086/301844
20. Pratt SC Daly MJ Kruglyak L Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components Am J Hum Genet 2000, 66(3):1153-1157 1288151 10712227 10.1086/302830
21. Almasy L Dyer TD Blangero J Bivariate quantitative trait linkage analysis: Pleiotropy versus co-incident linkages Genet Epidemiol 1997, 14(6):953-958 10.1002/ (SICI)1098-2272(1997)14:6<953::AID-GEPI65>3.0.CO;2-K 9433606
22. Lander E Kruglyak L Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results Nat Genet 1995, 11(3):241-247 10.1038/ng1195-241 7581446
23. Mayosi BM Avery PJ Farrall M Keavney B Watkins H Genome-wide linkage analysis of electrocardiographic and echocardiographic left ventricular hypertrophy in families with hypertension Eur Heart J 2008, 29(4):525-530 10.1093/eurheartj/ehn028 18276622
24. Devereux RB Left ventricular diastolic dysfunction: Early diastolic relaxation and late diastolic compliance J Am Coll Cardiol 1989, 13(2):337-339 2913111
25. Katz AM Physiology of the heart New York: Raven Press 2 1992
26. Morgan JP Abnormal intracellular modulation of calcium as a major cause of cardiac contractile dysfunction N Engl J Med 1991, 325(9):625-632 1861696
27. Garner C Lecomte E Visvikis S Abergel E Lathrop M Soubrier F Genetic and environmental influences on left ventricular mass. A family study Hypertension 2000, 36(5):740-746 11082137
28. Hirschhorn JN Lindgren CM Daly MJ Kirby A Schaffner SF Burtt NP Altshuler D Parker A Rioux JD Platko J et al Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height Am J Hum Genet 2001, 69(1):106-116 1226025 11410839 10.1086/321287
29. Perola M Ohman M Hiekkalinna T Leppavuori J Pajukanta P Wessman M Koskenvuo M Palotie A Lange K Kaprio J et al Quantitative-trait-locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups Am J Hum Genet 2001, 69(1):117-123 1226026 11410840 10.1086/321286
30. Rice T Chagnon YC Perusse L Borecki IB Ukkola O Rankinen T Gagnon J Leon AS Skinner JS Wilmore JH et al A genomewide linkage scan for abdominal subcutaneous and visceral fat in black and white families: The HERITAGE Family Study Diabetes 2002, 51(3):848-855 10.2337/diabetes.51.3.848 11872690
31. Barouch LA Harrison RW Skaf MW Rosas GO Cappola TP Kobeissi ZA Hobai IA Lemmon CA Burnett AL O'Rourke B et al Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms Nature 2002, 416(6878):337-339 11907582
32. Kim NN Villegas S Summerour SR Villarreal FJ Regulation of cardiac fibroblast extracellular matrix production by bradykinin and nitric oxide J Mol Cell Cardiol 1999, 31(2):457-466 10.1006/jmcc.1998.0887 10093057
33. Kemp BE Mitchelhill KI Stapleton D Michell BJ Chen ZP Witters LA Dealing with energy demand: The AMP-activated protein kinase Trends Biochem Sci 1999, 24(1):22-25 10.1016/S0968-0004(98)01340-1 10087918
34. Arad M Benson DW Perez-Atayde AR McKenna WJ Sparks EA Kanter RJ McGarry K Seidman JG Seidman CE Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy J Clin Invest 2002, 109(3):357-362 150860 11827995
35. Vasan RS Larson MG Aragam J Wang TG Mitchell GF Kathiresan S Newton-Cheh C Vita JA Keyes MJ O'Donnell CJ et al Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study BMC Medical Genetics 2007, 8(Suppl 1):S2 1995617 17903301 10.1186/1471-2350-8-S1-S2
36. NCBI-dbGAP http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id= phs000007