Effect of estrogen deprivation on the expression of aquaporins and nitric oxide synthases in rat vagina

Journal of Sexual Medicine

Volumn 6, Issue 6, 2009, Pages 1579-1586

  Kim, Sun Ouck ^a   Lee, Hyun Suk ^a   Ahn, Kyuyoun ^b   Park, Kwangsung ^a  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Aquaporins; Castration; Nitric oxide synthase; Rat; Vagina

Indexed keywords

AQUAPORIN 1; AQUAPORIN 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ESTRADIOL; ESTROGEN; NEURONAL NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; HEMODYNAMICS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LAMINA PROPRIA; NERVE FIBER; NERVE STIMULATION; NONHUMAN; OVARIECTOMY; PELVIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPRAGUE DAWLEY RAT; VAGINA; VAGINA EPITHELIUM; VAGINA SECRETION; WATER TRANSPORT; WESTERN BLOTTING;

EID: 66649104865     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2009.01223.x     Document Type: Article

References (25)

1. Goldstein I, Berman JR. Vasculogenic female sexual dysfunction: Vaginal engorgement and clitoral erectile insufficiency syndromes. Int J Impot Res 1998;10(2 suppl):S84-90.
2. Shabsihg A, Buttyan R, Burchardt T, Buchardt M, Hayek OR, Agati VD, Olsson C, Shabsigh R. The microvascular architecture of the rat vagina revealed by image analysis of vascular corrosion casts. Int J Impot Res 1999;11(1 suppl):S23-30.
3. Giuliano F, Allard J, Compagnie S, Alexandre L, Droupy S, Bernabe J. Vaginal physiological changes in a model of sexual arousal in anesthetized rats. Am J Physiol 2001;281:R140-9.
4. Giuliano F, Rampin O, Allard J. Neurophysiology and pharmacology of female genital sexual response. J Sex Marital Ther 2002;28:101-21.
5. Park K, Ahn K, Lee S, Ryu S, Park Y, Azadzoi KM. Decreased circulating levels of estrogen alter vaginal and clitoral blood flow and structure in the rabbit. Int J Impot Res 2001;13:116-24.
6. Min K, Munarriz R, Kim NN, Choi S, O'Connell L, Goldstein I, Traish AM. Effects of ovariectomy and estrogen replacement on basal and pelvic nerve stimulated vaginal lubrication in an animal model. J Sex Marital Ther 2003;29(1 suppl):S77-84.
7. Berman JR, McCarthy MM, Kyprianou N. Effect of estrogen withdrawal on nitric oxide synthase expression and apoptosis in the rat vagina. Urology 1998;51:650-6.
8. Al-Hijji J, Larsson B, Batra S. Nitric oxide synthase in the rabbit uterus and vagina: Hormonal regulation and functional significance. Biol Reprod 2000;62:1387-92.
9. Gannon BJ, Warnes GM, Carati CJ, Verco CJ. Aquaporin-1 expression in visceral smooth muscle cells of female rat reproductive tract. J Smooth Muscle Res 2000;36:155-67.
10. Li X, Yu H, Koide S. The water channel gene of the human uterus. Biochem Mol Biol Int 1994;32:371-7.
11. Jablonski EM, McConnell NA, Hughes FM Jr, Huet-Hudson YM. Estrogen regulation of aquaporins in the mouse uterus: Potential roles in uterine water movement. Biol Reprod 2003;69:1481-7.
12. Park K, Han HJ, Kim SW, Jung SI, Kim SO, Lee HS, Lee MN, Ahn K. Expression of aquaporin water channels in rat vagina: Potential role in vaginal lubrication. J Sex Med 2008;5:77-82.
13. Bouley R, Breton S, Sun T, McLaughlin M, Nsumu NN, Lin HY, Ausiello DA, Brown D. Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells. J Clin Invest 2000;106:1115-26.
14. Combet S, Van Landschoot M, Moulin P, Piech A, Verbavatz JM, Goffin E, Balligand JL, Lameire N, Devuyst O. Regulation of aquaporin-1 and nitric oxide synthase isoforms in a rat model of acute peritonitis. J Am Soc Nephrol 1999;10:2185-96.
15. Paavonen J. Physiology and ecology of the vagina. Scand J Infect Dis 1983;40:S31-5.
16. Levin RJ. The physiology of sexual function in women. Clin Obstet Gynecol 1980;7:213-51.
17. Sarrel PM. Sexuality and menopause. Obstet Gynecol 1990;75(4 suppl):S26-30.
18. Schwenkhagen A. Hormonal changes in menopause and implications on sexual health. J Sex Med 2007;4(3 suppl):220-6.
19. Goldstein I. Current management strategies of the postmenopausal patient with sexual health problems. J Sex Med 2007;4(3 suppl):235-53.
20. Diokno AC, Brown MB, Herzog AR. Sexual function in the elderly. Arch Intern Med 1990;150:197-200.
21. Kone BC. Nitric oxide synthesis in the kidney: Isoforms, biosynthesis, and functions in health. Semin Nephrol 2004;24:299-315.
22. Hayashi T, Yamada K, Esaki T, Mutoh E, Iguchi A. Effect of estrogen on isoforms of nitric oxide synthase: Possible mechanism of anti-atherosclerotic effect of estrogen. Gerontology 1997;43(1 suppl):S24-34.
23. Verkman AS. More than just water channels: Unexpected cellular roles of aquaporins. J Cell Sci 2005;118:3225-35.
24. Richard C, Gao J, LaFleur B, Christman BW, Anderson J, Brown N, Reese J. Patency of the preterm fetal ductus arteriosus is regulated by endothelial nitric oxide synthase and is independent of vasa vasorum in the mouse. Am J Physiol Regul Integr Comp Physiol 2004;287:R652-60.
25. Braam B. Renal endothelial and macula densa NOS: Integrated response to changes in extracellular fluid volume. Am J Physiol 1999;276:1551-61.